{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:04:23Z","timestamp":1761930263234,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Ophtalmologique Adolphe de Rothschild","award":["202002873"],"award-info":[{"award-number":["202002873"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The recent outbreak of the Coronavirus SARS-CoV-2 has been declared a worldwide pandemic. Within various multi-organ involvement, several ocular manifestations have been described, such as conjunctivitis and retinopathy. The prevalence and severity of retinal lesions and their relation to the severity of the systemic disease are unknown. We performed a prospective, observational study on 172 consecutively hospitalized patients with acute confirmed COVID-19 infection. All patients underwent screening widefield fundus photography at the time of hospital admission. Despite no ocular or vision-related symptoms, we found cotton wool spots (CWS) and\/or hemorrhages in 19\/172 patients (11%). Diabetes history, overweight, and elevated C-reactive protein were more frequently observed among patients with retinal abnormalities, while a history of systemic hypertension was more frequently observed among patients without retinal findings. At a 3-month follow-up visit, CWS had subsided in all patients.<\/jats:p>","DOI":"10.3390\/jcm11071828","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:27:51Z","timestamp":1648416471000},"page":"1828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Retinal Manifestations in Patients with COVID-19: A Prospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-2516","authenticated-orcid":false,"given":"Eleonora","family":"Riotto","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University Hospital Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"M\u00e9gevand","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"M\u00e9gevand","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2016-6759","authenticated-orcid":false,"given":"Christophe","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-5062","authenticated-orcid":false,"given":"Jerome","family":"Pugin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Hospital Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros N.","family":"Stangos","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Centre A. Rothschild, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Marconi Archinto","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Geneva University, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Sunaric M\u00e9gevand","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Centre A. Rothschild, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2020013","DOI":"10.4178\/epih.e2020013","article-title":"WHO International Health Regulations Emergency Committee for the COVID-19 outbreak","volume":"42","author":"Jee","year":"2020","journal-title":"Epidemiol. Health"},{"key":"ref_2","unstructured":"(2021, April 17). Coronavirus Resource Center. Available online: https:\/\/coronavirus.jhu.edu."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2020.04.003","article-title":"Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China","volume":"98","author":"Su","year":"2020","journal-title":"Kidney Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/eurheartj\/ehaa623","article-title":"COVID-19 is, in the end, an endothelial disease","volume":"41","author":"Libby","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tcm.2020.10.005","article-title":"COVID-19\u2014A vascular disease","volume":"31","author":"Siddiqi","year":"2021","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.abb8925","article-title":"Cytokine release syndrome in severe COVID-19","volume":"368","author":"Moore","year":"2020","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S2213-2600(20)30404-5","article-title":"Cytokine elevation in severe and critical COVID-19: A rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes","volume":"8","author":"Leisman","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1021\/acschemneuro.1c00353","article-title":"Neurological Manifestations in COVID-19 Patients: A Meta-Analysis","volume":"12","author":"Vitalakumar","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(20)31014-X","article-title":"Retinal findings in patients with COVID-19","volume":"395","author":"Marinho","year":"2020","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/joim.13156","article-title":"COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease","volume":"289","author":"Landecho","year":"2020","journal-title":"J. Int. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17419","DOI":"10.1038\/s41598-020-74446-6","article-title":"Retinal involvement and ocular findings in COVID-19 pneumonia patients","volume":"10","author":"Pirraglia","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bjophthalmol-2020-317576","article-title":"Retinal findings in hospitalised patients with severe COVID-19","volume":"106","author":"Pereira","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/ceo.13919","article-title":"Longitudinal analysis of cotton wool spots in COVID-19 with high-resolution spectral domain optical coherence tomography and optical coherence tomography angiography","volume":"49","author":"Markan","year":"2021","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100550","DOI":"10.1016\/j.eclinm.2020.100550","article-title":"Retinal findings in patients with COVID-19: Results from the SERPICO-19 study","volume":"27","author":"Invernizzi","year":"2020","journal-title":"eClinicalMedicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joco.2016.09.009","article-title":"Therapeutic targets of renin-angiotensin system in ocular disorders","volume":"29","author":"Choudhary","year":"2016","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Patel, P.S., and Sadda, S.R. (2013). Chapter 51\u2014Retinal Artery Obstructions. Retina, Elsevier. [5th ed.].","DOI":"10.1016\/B978-1-4557-0737-9.00051-5"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s11239-020-02297-z","article-title":"Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: Potential role of complement system inhibition in COVID-19","volume":"51","author":"Wang","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/jth.14859","article-title":"D-dimer levels on admission to predict in-hospital mortality in patients with COVID-19","volume":"18","author":"Zhang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.survophthal.2005.12.003","article-title":"Purtscher\u2019s and Purtscher-like Retinopathies: A Review","volume":"51","author":"Agrawal","year":"2006","journal-title":"Surv. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ajo.2021.03.015","article-title":"Optical Coherence Tomography Angiography Features in Post-COVID-19 Pneumonia Patients: A Pilot Study","volume":"227","author":"Cennamo","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.medcli.2020.12.006","article-title":"Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection","volume":"156","year":"2021","journal-title":"Med. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.preteyeres.2011.05.001","article-title":"Acute retinal arterial occlusive disorders","volume":"30","author":"Hayreh","year":"2011","journal-title":"Prog. Retin. Eye Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1828\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:43:34Z","timestamp":1760136214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcm11071828"],"URL":"https:\/\/doi.org\/10.3390\/jcm11071828","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,3,25]]}}}