{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:59:01Z","timestamp":1760151541323,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"publisher","award":["STRATEGMED1\/233547\/13\/NCBR\/2015"],"award-info":[{"award-number":["STRATEGMED1\/233547\/13\/NCBR\/2015"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Aims: The objective of the study was to evaluate the effects of individually prescribed hybrid comprehensive telerehabilitation (HCTR) implemented at patients\u2019 homes on left ventricular (LV) diastolic function in heart failure (HF) patients. Methods and results: The Telerehabilitation in Heart Failure Patients trial (TELEREH-HF) is a multicenter, prospective, randomized (1:1), open-label, parallel-group, controlled trial involving HF patients assigned either to HCTR involving a remotely monitored home training program in conjunction with usual care (HCTR group) or usual care only (UC group). The patient in the HCTR group underwent a 9-week HCTR program consisting of two stages: an initial stage (1 week) conducted in hospital and the subsequent stage (eight weeks) of home-based HCTR five times weekly. Due to difficulties of proper assessment and differences in the evaluation of diastolic function in patients with atrial fibrillation, we included in our subanalysis only patients with sinus rhythm. Depending on the grade of diastolic dysfunction, patients were assigned to subgroups with mild diastolic (MDD) or severe diastolic dysfunction (SDD), both in HCTR (HCTR-MDD and HCTR-SDD) and UC groups (UC-MDD and UC-SDD). Changes from baseline to 9 weeks in echocardiographic parameters were seen only in A velocities in HCTR-MDD vs. UC-MDD; no significant shifts between groups of different diastolic dysfunction grades were observed after HCTR. All-cause mortality was higher in UC-SDD vs. UC-MDD with no difference between HCTR-SDD and HCTR-MDD. Higher probability of HF hospitalization was observed in HCTR-SDD than HCTR-MDD and in UC-SDD than UC-MDD. No differences in the probability of cardiovascular mortality and hospitalization were found. Conclusions: HCTR did not influence diastolic function in HF patients in a significant manner. The grade of diastolic dysfunction had an impact on mortality only in the UC group and HF hospitalization over a 12\u201324-month follow-up in HCTR and UC groups.<\/jats:p>","DOI":"10.3390\/jcm11071844","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:27:51Z","timestamp":1648416471000},"page":"1844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Impact of Hybrid Comprehensive Telerehabilitation Regarding Diastolic Dysfunction in Patients with Heart Failure with Reduced Ejection Fraction\u2014Subanalysis of the TELEREH-HF Randomized Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"given":"Robert","family":"Irzma\u0144ski","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiac Rehabilitation, Medical University of \u0141\u00f3d\u017a, 90-647 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Glowczynska","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-6874","authenticated-orcid":false,"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Medical University of \u0141\u00f3d\u017a, 90-647 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Szalewska","sequence":"additional","affiliation":[{"name":"Clinic of Rehabilitation Medicine, Faculty of Health Sciences, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"Piotrowicz","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology, 04-628 Warsaw, Poland"},{"name":"Warsaw Academy of Medical Rehabilitation, 01-234 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5109","authenticated-orcid":false,"given":"Ilona","family":"Kowalik","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Pencina","sequence":"additional","affiliation":[{"name":"The Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-1231","authenticated-orcid":false,"given":"Piotr","family":"Orzechowski","sequence":"additional","affiliation":[{"name":"Telecardiology Center, National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Pluta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Silesian Medical University, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Kalarus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Silesian Medical University, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Opolski","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Piotrowicz","sequence":"additional","affiliation":[{"name":"Telecardiology Center, National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1513\/AnnalsATS.201710-789KV","article-title":"Pathophysiology of Chronic Systolic Heart Failure. A View from the Periphery","volume":"15","author":"Katz","year":"2018","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_2","first-page":"465","article-title":"Heart failure with preserved ejection fraction: A growing global epidemic","volume":"48","author":"Naing","year":"2019","journal-title":"AJGP"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/2047487317750437","article-title":"Characteristics and prognosis of heart failure with improved compared with persistently reduced ejection fraction: A systematic review and meta-analyses","volume":"25","author":"Andersson","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e004766","DOI":"10.1161\/JAHA.116.004766","article-title":"What Is the Evidence That the Tissue Doppler Index E\/e\u2032 Reflects Left Ventricular Filling Pressure Changes After Exercise or Pharmacological Intervention for Evaluating Diastolic Function? A Systematic Review","volume":"6","author":"Sharifov","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.echo.2018.11.011","article-title":"Pathophysiology and Echocardiographic Diagnosis of Left Ventricular Diastolic Dysfunction","volume":"32","author":"Silbiger","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/ehaa605","article-title":"2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease The Task Force on sports cardiology and exercise in patients with cardiovascular disease of the European Society of Cardiology (ESC)","volume":"42","author":"Pelliccia","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_8","first-page":"CD003331","article-title":"Exercise-based cardiac rehabilitation for adults with heart failure","volume":"1","author":"Long","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ejhf.1594","article-title":"Survival of patients with chronic heart failure in the community: A systematic review and meta-analysis","volume":"21","author":"Jones","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jamacardio.2019.5006","article-title":"Effects of a 9-Week Hybrid Comprehensive Telerehabilitation Program on Long-term Outcomes in Patients With Heart Failure: The Telerehabilitation in Heart Failure Patients (TELEREH-HF) Randomized Clinical Trial","volume":"5","author":"Piotrowicz","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ahj.2019.08.015","article-title":"Hybrid comprehensive telerehabilitation in heart failure patients (TELEREH-HF): A randomized, multicenter, prospective, open-label, parallel group controlled trial-Study design and description of the intervention","volume":"217","author":"Piotrowicz","year":"2019","journal-title":"Am. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.hfc.2021.01.007","article-title":"Exercise-Based Cardiac Rehabilitation Programs in Heart Failure Patients","volume":"17","author":"Patti","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"ref_13","first-page":"74","article-title":"Telerehabilitation for patients with heart failure","volume":"5","author":"Tousignant","year":"2015","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.rehab.2018.01.003","article-title":"Effect of exercise training on left ventricular mechanics after acute myocardial infarction\u2013an exploratory study","volume":"61","author":"McGregor","year":"2018","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_15","first-page":"1","article-title":"Noninvasive imaging assessment of rehabilitation therapy in heart failure with preserved and reduced left ventricular ejection fraction (IMAGING-REHAB-HF): Design and rationale","volume":"10","author":"Quinaglia","year":"2019","journal-title":"Ther. Adv. Chronic. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jcmg.2018.10.038","article-title":"Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography","volume":"13","author":"Nagueh","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijcard.2020.11.056","article-title":"Diastolic dysfunction, frailty and prognosis in elderly patients with acute coronary syndromes","volume":"327","author":"Pavasini","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.hfc.2021.01.008","article-title":"Role of Cardiac Rehabilitation after Ventricular Assist Device Implantation","volume":"17","author":"Guidetti","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ahj.2007.01.004","article-title":"Exercise training in systolic and diastolic dysfunction: Effects on cardiac function, functional capacity, and quality of life","volume":"153","author":"Smart","year":"2007","journal-title":"Am. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10554-012-0152-z","article-title":"Impact of cardiac rehabilitation exercise program on left ventricular diastolic function in coronary artery disease: A pilot study","volume":"29","author":"Wuthiwaropas","year":"2013","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lee, J., Kim, J., Sun, B.J., Jee, S.J., and Park, J. (2021). Effect of Cardiac Rehabilitation on Left Ventricular Diastolic Function in Patients with Acute Myocardial Infarction. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102088"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1249\/MSS.0b013e31823cd16a","article-title":"Exercise Training Improves Diastolic Function in Heart Failure Patients","volume":"44","author":"Alves","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10741-017-9600-0","article-title":"Effect of exercise on diastolic function in heart failure patients: A systematic review and meta-analysis","volume":"22","author":"Pearson","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fcvm.2019.00140","article-title":"The Role of the TGF-\u03b2 Superfamily in Myocardial Infarction","volume":"6","author":"Hanna","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3109\/14017431.2016.1163416","article-title":"Association diastolic function by echo and infarct size by magnetic resonance imaging after STEMI","volume":"50","author":"Andersen","year":"2016","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.hipert.2017.01.001","article-title":"Diastolic dysfunction in hypertension","volume":"34","author":"Leao","year":"2017","journal-title":"Hipertens. Riesgo VascJul."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.5543\/tkda.2014.76282","article-title":"Does cardiac rehabilitation improve left ventricular diastolic function of patients with acute myocardial infarction?","volume":"42","author":"Acar","year":"2014","journal-title":"Turk Kardiyol Dern Ars"},{"key":"ref_28","first-page":"125","article-title":"Can cardiac rehabilitation programs improve functional capacity and left ventricular diastolic function in patients with mechanical reperfusion after ST elevation myocardial infarction? A double-blind clinical trial","volume":"8","author":"Golabchi","year":"2012","journal-title":"ARYA Atheroscler."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1450","DOI":"10.1097\/MD.0000000000001450","article-title":"The Effect of Exercise Training on Diastolic and Systolic Function After Acute Myocardial Infarction A Randomized Study","volume":"94","author":"Azevedo","year":"2015","journal-title":"Medicine"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1844\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:43:58Z","timestamp":1760136238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,26]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcm11071844"],"URL":"https:\/\/doi.org\/10.3390\/jcm11071844","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,3,26]]}}}