{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:57:23Z","timestamp":1760151443237,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: The aim of this study was to evaluate the mid-term efficacy of drug-coated balloons (DCB) in percutaneous coronary intervention (PCI) in two different pathophysiologic scenarios. Background: There are different underlying pathological processes in coronary artery disease. Mid-term safety and efficacy of DCB approach is still limited. Methods: Medical records of all consecutive patients undergoing DCB were evaluated. The primary endpoint was the rate of clinically driven target lesion revascularization (TLR) after 24 months. Results: Between January 2011 and December 2017, 442 patients were included, representing 4.4% of all PCIs in our institution. A total of 460 DCB lesions were treated, of which 328 (71.3%) were de novo and 132 (28.7%) were combined bare metal or drug-eluting stents with in-stent restenosis (ISR). The patients\u2019 mean age was 66.2 \u00b1 11.7 years with a diabetes prevalence of 45.3%. The TLR rate was lower in the de novo group (5.3%) compared to the ISR group (9.4%) (p = 0.04). No differences were observed in major adverse cardiovascular events (MACE) between the de novo group (38.9%) and ISR group (42.5%) (p = 0.47). No significant differences were detected in the TLR occurrence in the subgroup analysis. Conclusion: Our extended experience demonstrates that the mid-term DCB approach in these two pathophysiologic settings represent a reasonable option, with low TLR rate.<\/jats:p>","DOI":"10.3390\/jcm11071859","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:27:51Z","timestamp":1648416471000},"page":"1859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mid-Term Clinical Outcomes Following Drug-Coated Balloons in Coronary Artery Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Gal","family":"Sella","sequence":"first","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gera","family":"Gandelman","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholay","family":"Teodorovich","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ortal","family":"Tuvali","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Ayyad","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Abu Khadija","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Haberman","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lion","family":"Poles","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jonas","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Volodarsky","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Blatt","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem 91905, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.amjmed.2008.10.018","article-title":"Clinical management of atherosclerosis: A checklist","volume":"122","author":"Insull","year":"2009","journal-title":"Am. 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