{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:47:31Z","timestamp":1790682451744,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed, especially among children and adolescents. Currently, few studies focus on the differentiation of inflammation in IBD subunits, i.e., Crohn\u2019s Disease (CD) and Ulcerative Colitis (UC). The aim of this study was to compare the concentrations of proinflammatory mediators of arachidonic acid (ARA) and linoleic acid (LA) in patients with CD (n = 34) and UC (n = 30), in order to identify differences in inflammation in both diseases and within the same entity, according to disease activity. Sixty-four adolescents with a mean age of 13.76 \u00b1 2.69 and 14.15 \u00b1 3.31, for CD and UC, respectively, were enrolled in the study. Biochemical analysis of ARA and LA derivatives was performed using a liquid chromatography. A trend was observed in the concentration of 15S-HETE (hydroxyeicosatetraenoic acids) in CD relative to UC. The active phase of both diseases showed a higher 15S-HETE concentration in active CD relative to active UC. Comparing patients with CD with active and inactive disease showed a trend of increased levels of thromboxane B2, leukotriene B4 and 9S-HODE (hydroxyoctadecadienoic acid) in the active versus the inactive disease. We also observed statistically significantly higher levels of 12S-HETE in inactive CD relative to active CD. In the UC group, on the other hand, statistically significantly higher levels of prostaglandin E2 and 16RS-HETE were observed in active UC relative to inactive UC. Moreover, significantly higher concentrations of LTX A4 5S, 6R were observed in inactive UC relative to the active phase. In conclusion, the present study indicated the activity of the 15-LOX pathway in CD. Further studies involving lipid mediators in patients with IBD may contribute to the development of new therapies for the treatment of IBD. The identification of differences in the course of inflammation may help to target therapy in CD and UC, and perhaps allow the introduction of an additional diagnostic marker between the two main IBD subtypes.<\/jats:p>","DOI":"10.3390\/jcm11071861","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:27:51Z","timestamp":1648416471000},"page":"1861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Involvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn\u2019s Disease (CD) and Ulcerative Colitis (UC)"],"prefix":"10.3390","volume":"11","author":[{"given":"Justyna","family":"Kikut","sequence":"first","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, W. Broniewskiego 24, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Mokrzycka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hemato-Oncology and Pediatric Gastroenterology, Independent Public Clinical Hospital No.1 of Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arleta","family":"Drozd","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, W. Broniewskiego 24, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Grzybowska-Chlebowczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w 16, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-0670","authenticated-orcid":false,"given":"Maciej","family":"Zi\u0119tek","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Obstetrics and Gynecology Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-0624","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Szczuko","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, W. Broniewskiego 24, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Greenwood-Van Meerveld, B. (2017). Inflammatory Bowel Disease: Pathophysiology and Current Therapeutic Approaches. Gastrointestinal Pharmacology, Springer International Publishing. Handbook of Experimental Pharmacology.","DOI":"10.1007\/978-3-319-56360-2"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.0105-2896.2005.00293.x","article-title":"Defects in Mucosal Immunity Leading to Crohn\u2019s Disease","volume":"206","author":"Cobrin","year":"2005","journal-title":"Immunol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6679316","DOI":"10.1155\/2021\/6679316","article-title":"Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis","volume":"2021","author":"Sheng","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/MOG.0000000000000680","article-title":"Evaluation of very early-onset inflammatory bowel disease","volume":"36","author":"Shouval","year":"2020","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8495913","DOI":"10.1155\/2019\/8495913","article-title":"The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease","volume":"2019","author":"Ma","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.3748\/wjg.v24.i25.2741","article-title":"Current Global Trends in the Incidence of Pediatric-Onset Inflammatory Bowel Disease","volume":"24","author":"Schwarz","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dmochowska, N., Wardill, H.R., and Hughes, P.A. (2018). Advances in Imaging Specific Mediators of Inflammatory Bowel Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092471"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/14712598.2019.1652267","article-title":"Inflammatory Cytokines: From Discoveries to Therapies in IBD","volume":"19","author":"Marafini","year":"2019","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fmed.2020.00123","article-title":"Serum Biomarkers for Inflammatory Bowel Disease","volume":"7","author":"Chen","year":"2020","journal-title":"Front. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1053\/j.gastro.2015.07.003","article-title":"Biomarkers of Inflammation in Inflammatory Bowel Disease","volume":"149","author":"Sands","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1515\/cclm-2016-0522","article-title":"Fecal Calprotectin in Inflammatory Bowel Diseases: Update and Perspectives","volume":"55","author":"Manceau","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.gastro.2021.04.063","article-title":"Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User\u2019s Guide for Adult and Pediatric Gastroenterologists","volume":"161","author":"Agrawal","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000511641","article-title":"Biomarkers of Inflammation in Inflammatory Bowel Disease: How Long before Abandoning Single-Marker Approaches?","volume":"39","author":"Dragoni","year":"2021","journal-title":"Dig. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Camba-G\u00f3mez, M., Gualillo, O., and Conde-Aranda, J. (2021). New Perspectives in the Study of Intestinal Inflammation: Focus on the Resolution of Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052605"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","article-title":"Pathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease","volume":"578","author":"Graham","year":"2020","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/gutjnl-2013-305304","article-title":"Long-Term Intake of Dietary Fat and Risk of Ulcerative Colitis and Crohn\u2019s Disease","volume":"63","author":"Ananthakrishnan","year":"2014","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.crohns.2013.03.013","article-title":"Altered Colonic Mucosal Availability of N-3 and n-6 Polyunsaturated Fatty Acids in Ulcerative Colitis and the Relationship to Disease Activity","volume":"8","author":"Pearl","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12944-015-0165-4","article-title":"Inflammatory Bowel Disease as a Disorder of an Imbalance between Pro-and Anti-Inflammatory Molecules and Deficiency of Resolution Bioactive Lipids","volume":"15","author":"Das","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/ibd.21560","article-title":"New Insights into the Role of Fatty Acids in the Pathogenesis and Resolution of Inflammatory Bowel Disease","volume":"17","author":"Shores","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/00365521.2018.1447597","article-title":"Immunopathogenesis of Inflammatory Bowel Disease and Mechanisms of Biological Therapies","volume":"53","author":"Ahluwalia","year":"2018","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Scaioli, E., Liverani, E., and Belluzzi, A. (2017). The Imbalance between N-6\/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122619"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Klawitter, J., Zafar, I., Klawitter, J., Pennington, A.T., Klepacki, J., Gitomer, B.Y., Schrier, R.W., Christians, U., and Edelstein, C.L. (2013). Effects of Lovastatin Treatment on the Metabolic Distributions in the Han:SPRD Rat Model of Polycystic Kidney Disease. BMC Nephrol., 14.","DOI":"10.1186\/1471-2369-14-165"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MOG.0000000000000075","article-title":"The universe of arachidonic acid metabolites in inflammatory bowel disease: Can we tell the good from the bad?","volume":"30","author":"Stenson","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1038\/s41598-019-39232-z","article-title":"Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn\u2019s Disease","volume":"9","author":"Scoville","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1021\/cr100396c","article-title":"Resolvins and Protectins in Inflammation-Resolution","volume":"111","author":"Serhan","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.prostaglandins.2005.10.004","article-title":"Lipoxin Biosynthesis in Inflammatory Bowel Disease","volume":"79","author":"Mangino","year":"2006","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/gast.2003.50154","article-title":"Lipoxins: Pro-Resolution Lipid Mediators in Intestinal Inflammation","volume":"124","author":"Goh","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12023","DOI":"10.1073\/pnas.1004982107","article-title":"A Pro-Resolution Mediator, Prostaglandin D2, Is Specifically up-Regulated in Individuals in Long-Term Remission from Ulcerative Colitis","volume":"107","author":"Vong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The Resolution Code of Acute Inflammation: Novel Pro-Resolving Lipid Mediators in Resolution","volume":"27","author":"Serhan","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/bph.14178","article-title":"Eicosanoids in the Gastrointestinal Tract","volume":"176","author":"Wallace","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.autrev.2017.02.013","article-title":"IBD Immunopathogenesis: A Comprehensive Review of Inflammatory Molecules","volume":"16","author":"Park","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/ibd.20094","article-title":"Colonic Expression of Leukotriene-Pathway Enzymes in Inflammatory Bowel Diseases","volume":"13","author":"Jupp","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00365529509093234","article-title":"Altered Leukotriene B4 Metabolism in Colonic Mucosa with Inflammatory Bowel Disease","volume":"30","author":"Ikehata","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0016-5085(84)80015-3","article-title":"Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease","volume":"86","author":"Sharon","year":"1984","journal-title":"Gastroenterology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"C53","DOI":"10.1007\/BF01991025","article-title":"15-HETE Is the Main Eicosanoid Formed by Human Colonic Mucosa","volume":"36","author":"Zijlstra","year":"1992","journal-title":"Agents Actions"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbalip.2014.10.008","article-title":"Biosynthesis, Biological Effects, and Receptors of Hydroxyeicosatetraenoic Acids (HETEs) and Oxoeicosatetraenoic Acids (Oxo-ETEs) Derived from Arachidonic Acid","volume":"1851","author":"Powell","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"C73","DOI":"10.1007\/BF01991027","article-title":"Species Differences in the Pattern of Eicosanoids Produced by Inflamed and Non-Inflamed Tissue","volume":"36","author":"Zijlstra","year":"1992","journal-title":"Agents Actions"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kulkarni, A., Nadler, J.L., Mirmira, R.G., and Casimiro, I. (2021). Regulation of Tissue Inflammation by 12-Lipoxygenases. Biomolecules, 11.","DOI":"10.3390\/biom11050717"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"40686","DOI":"10.1074\/jbc.M004512200","article-title":"A Novel Hepatointestinal Leukotriene B4 Receptor: Cloning and Functional Characterization","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/00365529009091903","article-title":"Role of Eicosanoids as Mediators of Inflammation in Inflammatory Bowel Disease","volume":"172","author":"Stenson","year":"1990","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0016-5085(88)90284-3","article-title":"In Vivo Profiles of Eicosanoids in Ulcerative Colitis, Crohn\u2019s Colitis, and Clostridium Difficile Colitis","volume":"95","author":"Lauritsen","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00004836-199603000-00009","article-title":"Increased Prostaglandin E2 and Leukotriene B4 Synthesis in Isolated Colonic Mucosal Cells in Inflammatory Bowel Disease: A Preliminary Report","volume":"22","author":"Baumeister","year":"1996","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1038\/s41598-020-69831-0","article-title":"Lipoxins, RevD1 and 9, 13 HODE as the Most Important Derivatives after an Early Incident of Ischemic Stroke","volume":"10","author":"Szczuko","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.plipres.2013.09.001","article-title":"The Eosinophil Chemoattractant 5-Oxo-ETE and the OXE Receptor","volume":"52","author":"Powell","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"eaal2171","DOI":"10.1126\/scisignal.aal2171","article-title":"5-OxoETE Triggers Nociception in Constipation-Predominant Irritable Bowel Syndrome through MAS-Related G Protein\u2013Coupled Receptor D","volume":"11","author":"Bautzova","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1194\/jlr.M079095","article-title":"Production of Lipid Mediators across Different Disease Stages of Dextran Sodium Sulfate-Induced Colitis in Mice","volume":"59","author":"Hamabata","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_49","first-page":"G104","article-title":"Induction of Epithelial Arachidonate 12-Lipoxygenase at Active Sites of Inflammatory Bowel Disease","volume":"264","author":"Shannon","year":"1993","journal-title":"Am. J. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Masoodi, M., Pearl, D.S., Eiden, M., Shute, J.K., Brown, J.F., Calder, P.C., and Trebble, T.M. (2013). Altered Colonic Mucosal Polyunsaturated Fatty Acid (PUFA) Derived Lipid Mediators in Ulcerative Colitis: New Insight into Relationship with Disease Activity and Pathophysiology. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076532"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0952-3278(91)90133-P","article-title":"15-HETE Is the Main Eicosanoid Present in Mucus of Ulcerative Proctocolitis","volume":"43","author":"Zijlstra","year":"1991","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.4049\/jimmunol.168.10.5260","article-title":"Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis","volume":"168","author":"Gewirtz","year":"2002","journal-title":"J. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Vong, L., Ferraz, J.G.P., Dufton, N., Panaccione, R., Beck, P.L., Sherman, P.M., Perretti, M., and Wallace, J.L. (2012). Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039244"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"15736","DOI":"10.1073\/pnas.0404722101","article-title":"A Beta-Oxidation-Resistant Lipoxin A4 Analog Treats Hapten-Induced Colitis by Attenuating Inflammation and Immune Dysfunction","volume":"101","author":"Fiorucci","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/ibd\/izy349","article-title":"A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Na\u00efve and Deep Remission Ulcerative Colitis Patients and the Potential Link with Cytokine Gene Expression","volume":"25","author":"Diab","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.gastro.2015.09.038","article-title":"Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells from Patients with Crohn\u2019s Disease","volume":"150","author":"Pochard","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"21185","DOI":"10.1074\/jbc.M109.021634","article-title":"Phosphatidylethanolamine-Esterified Eicosanoids in the Mouse: Tissue Localization and Inflammation-Dependent Formation in Th-2 Disease","volume":"284","author":"Morgan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"G487","DOI":"10.1152\/ajpgi.00042.2011","article-title":"Aspirin-Triggered Lipoxin Enhances Macrophage Phagocytosis of Bacteria While Inhibiting Inflammatory Cytokine Production","volume":"301","author":"Prescott","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1097\/00006123-200012000-00029","article-title":"16(R)-Hydroxyeicosatetraenoic Acid, a Novel Cytochrome P450 Product of Arachidonic Acid, Suppresses Activation of Human Polymorphonuclear Leukocyte and Reduces Intracranial Pressure in a Rabbit Model of Thromboembolic Stroke","volume":"47","author":"Bednar","year":"2000","journal-title":"Neurosurgery"},{"key":"ref_60","first-page":"119","article-title":"Percentile charts for growth and nutritional status assessment in Polish children and adolescents from birth to 18 year of age","volume":"12","author":"Grajda","year":"2015","journal-title":"Stand. Med.\/Pediatr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1861\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:44:23Z","timestamp":1760136263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,27]]},"references-count":60,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcm11071861"],"URL":"https:\/\/doi.org\/10.3390\/jcm11071861","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,27]]}}}