{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:13:52Z","timestamp":1781140432053,"version":"3.54.1"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The purpose of this systematic review was to analyze sinus lifting procedures and to compare the efficiency of this treatment associated with the second generation of platelet-rich fibrin related to its effects on bone gain and to clarify the regenerative efficacy in sinus lift procedure, whether alone or as a coadjutant to other bone graft materials. The PICOT question was, \u201cIn clinical studies with patients needing a maxillary sinus lift (P), does the use of PRF either alone (I) or in conjunction with other biomaterials (C) improve the clinical outcome associated with bone gain and density (O), with at least three months of follow-up (T)?\u201d An electronic search was conducted in the MEDLINE (PubMed), Science Direct, and Scopus databases through a search strategy. A total of 443 articles were obtained from the electronic database search. Sixteen articles met all criteria and were included in this review. Within the limitation of this study and interpreting the results carefully, it was suggested that a higher risk for implant failure after a sinus elevation might be seen in patients with residual bone \u22644 mm, and PRF application was effective, suggesting reducing the time needed for new bone formation.<\/jats:p>","DOI":"10.3390\/jcm11071888","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:44:52Z","timestamp":1648590292000},"page":"1888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sinus Lift Associated with Leucocyte-Platelet-Rich Fibrin (Second Generation) for Bone Gain: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Ada Isis Pelaez","family":"Otero","sequence":"first","affiliation":[{"name":"Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504-505 Viseu, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-3544","authenticated-orcid":false,"given":"Juliana Campos Hasse","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Private Clinic, 3505-606 Viseu, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Borges","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504-505 Viseu, Portugal"},{"name":"Center for Interdisciplinary Research in Health (CIIS), 3504-505 Viseu, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-6096","authenticated-orcid":false,"given":"Leonardo","family":"Nassani","sequence":"additional","affiliation":[{"name":"Division of Restorative and Prosthetic Dentistry, The Ohio State University College of Dentistry, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-612X","authenticated-orcid":false,"given":"Rogerio de Moraes","family":"Castilho","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-4390","authenticated-orcid":false,"given":"Gustavo Vicentis de Oliveira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Health (CIIS), 3504-505 Viseu, Portugal"},{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/ten.teb.2007.0435","article-title":"Fibrin: A versatile scaffold for tissue engineering applications","volume":"14","author":"Ahmed","year":"2008","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.coms.2015.01.001","article-title":"Maxillary sinus bone augmentation techniques","volume":"27","author":"Carrao","year":"2015","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Atalay, B. (2019). Sinus lifting and leucocyte- and platelet-rich fibrin. Challenging Issues on Paranasal Sinuses, IntechOpen.","DOI":"10.5772\/intechopen.81163"},{"key":"ref_4","first-page":"77","article-title":"Endoscopic analysis of alterations in sinus floor elevation approaching the summers technique and immediate implant: A clinical trial with 10 years follow-up","volume":"58","author":"Rizzato","year":"2022","journal-title":"Int. J. Sci. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bennardo, F., Barone, S., Vocaturo, C., Nucci, L., Antonelli, A., and Giudice, A. (2022). Usefulness of Magnetic Mallet in Oral Surgery and Implantology: A Systematic Review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12010108"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1600-0722.2008.00571.x","article-title":"Implant survival rates after maxillary sinus augmentation","volume":"116","author":"Rosano","year":"2008","journal-title":"Eur. J. Oral Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Watanabe, T., Isobe, K., Suzuki, T., Kawabata, H., Nakamura, M., Tsukioka, T., Okudera, T., Okudera, H., Uematsu, K., and Okuda, K. (2017). An evaluation of the accuracy of the subtraction method used for determining platelet counts in advanced platelet-rich fibrin and concentrated growth factor preparations. Dent. J., 5.","DOI":"10.3390\/dj5010007"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/jemt.20968","article-title":"Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction","volume":"74","author":"Rodella","year":"2011","journal-title":"Microsc. Res. Tech."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/jcpe.12658","article-title":"Regenerative potential of leucocyte- and platelet-rich fibrin. Part B: Sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review","volume":"44","author":"Castro","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cid.12114","article-title":"Clinical efficacy of growth factors to enhance tissue repair in oral and maxillofacial reconstruction: A systematic review","volume":"17","author":"Schliephake","year":"2015","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1080\/09537104.2016.1267338","article-title":"Quantification of growth factors in different platelet concentrates","volume":"28","author":"Qiao","year":"2017","journal-title":"Platelets"},{"key":"ref_12","first-page":"2654645","article-title":"Sinus augmentation by platelet-rich fibrin alone: A report of two cases with histological examinations","volume":"2016","author":"Aoki","year":"2016","journal-title":"Case Rep. Dent."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/ID.0b013e3181faa8af","article-title":"Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: A six-year experience","volume":"20","author":"Simonpieri","year":"2011","journal-title":"Implant Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jbm.b.30886","article-title":"Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers","volume":"84","author":"Anitua","year":"2008","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.joms.2018.01.012","article-title":"Regenerative surgery: Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report","volume":"76","author":"Fortunato","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_16","first-page":"8397","article-title":"Effects of platelet-rich fibrin combined with guided bone regeneration in the reconstruction of peri-implantitis bone defect","volume":"13","author":"Sun","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12663-019-01197-x","article-title":"Maxillary sinus augmentation using xenograft and choukroun\u2019s platelet-rich fibrin as grafting material: A radiological study","volume":"1","author":"Kempraj","year":"2020","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/JPER.19-0290","article-title":"Quantification of growth factors in advanced platelet-rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects","volume":"91","author":"Lei","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/ID.0b013e3181f57288","article-title":"Osteotome-mediated sinus floor elevation using only platelet-rich fibrin: An early report on 110 patients","volume":"19","author":"Toffler","year":"2010","journal-title":"Implant Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1708-8208.2009.00233.x","article-title":"Bilateral sinus elevation evaluating plasma rich in growth factors technology: A report of five cases","volume":"14","author":"Anitua","year":"2012","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/clr.13655","article-title":"Radiologic comparative analysis between saline and platelet-rich fibrin filling after hydraulic transcrestal sinus lifting without adjunctive bone graft: A randomized controlled trial","volume":"31","author":"Cho","year":"2020","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/cid.12713","article-title":"Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial","volume":"21","author":"Pichotano","year":"2019","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/cid.12522","article-title":"Histologic and histomorphometric assessment of sinus-floor augmentation with beta-tricalcium phosphate alone or in combination with pure-platelet-rich plasma or platelet-rich fibrin: A randomized clinical trial","volume":"19","author":"Parlak","year":"2017","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jcms.2012.10.015","article-title":"Comparison of two different absorbable membranes for the coverage of lateral osteotomy sites in maxillary sinus augmentation: A preliminary study","volume":"41","author":"Gassling","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/clr.13044","article-title":"Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study","volume":"29","author":"Nizam","year":"2018","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e12347","DOI":"10.1111\/jicd.12347","article-title":"Comparison of the clinical, radiographic, and histological effects of titanium-prepared platelet rich fibrin to allograft materials in sinus-lifting procedures","volume":"9","author":"Olgun","year":"2018","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"872","DOI":"10.7150\/ijms.5119","article-title":"Platelet rich fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: Clinical and histological evaluations","volume":"9","author":"Tatullo","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"ref_29","first-page":"e984","article-title":"Sinus floor elevation with platelet-rich fibrin alone: A Clinical retrospective study of 1-7 years","volume":"10","author":"Aoki","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1563\/aaid-joi-D-17-00220","article-title":"Early placement of dental implants in maxillary sinus grafted with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral","volume":"44","author":"Pichotano","year":"2018","journal-title":"J. Oral Implantol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tripleo.2005.07.012","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift","volume":"101","author":"Choukroun","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40729-019-0166-6","article-title":"PRGF as adjunct to DBB in maxillary sinus floor augmentation: Histological results of a pilot split-mouth study","volume":"5","author":"Batas","year":"2019","journal-title":"Int. J. Implant Dent."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcms.2011.04.020","article-title":"Effects of Choukroun\u2019s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study","volume":"40","author":"Zhang","year":"2012","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wadhwani, C.P.K. (2015). Cementation in Dental Implantology, Springer.","DOI":"10.1007\/978-3-642-55163-5"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1708-8208.2007.00050.x","article-title":"A literature review on biomaterials in sinus augmentation procedures","volume":"9","author":"Browaeys","year":"2007","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tripleo.2009.06.044","article-title":"A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro","volume":"108","author":"He","year":"2009","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/JPER.19-0079","article-title":"Root coverage procedures for treating single and multiple recession-type defects: A Cochrane Systematic Review Updated","volume":"90","author":"Chambrone","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/08977190802636713","article-title":"Slow release of growth factors and thrombospondin-1 in Choukroun\u2019s platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies","volume":"27","author":"Doglioli","year":"2009","journal-title":"Growth Factors"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:45:08Z","timestamp":1760136308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/7\/1888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcm11071888"],"URL":"https:\/\/doi.org\/10.3390\/jcm11071888","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,28]]}}}