{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:41:14Z","timestamp":1791819674608,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Some evidence suggests a reduction in clinical and surgical recurrence after mesenteric resection in Crohn\u2019s Disease (CD). The aim of the REsection of the MEsentery StuDY (Remedy) was to assess whether mesenteric removal during surgery for ileocolic CD has an impact in terms of postoperative complications, endoscopic and ultrasonographic recurrences, and long-term surgical recurrence. Among the 326 patients undergoing primary resection between 2009 and 2019 in two referral centers, in 204 (62%) the mesentery was resected (Group A) and in 122 (38%) it was retained (Group B). Median follow-up was 4.7 \u00b1 3 years. Groups were similar in the peri-operative course. Endoscopic and ultrasonographic recurrences were 44.6% and 40.4% in Group A, and 46.7% and 41.2% in Group B, respectively, without statistically significant differences. The five-year time-to-event estimates, compared with the Log-rank test, were 3% and 4% for normal or thickened mesentery (p = 0.6), 2.8% and 4% for resection or sparing of the mesentery (p = 0.6), and 1.7% and 5.4% in patients treated with biological or immunosuppressants versus other adjuvant therapy (p = 0.02). In Cox\u2019s model, perforating behavior was a risk factor, and biological or immunosuppressant adjuvant therapy protective for surgical recurrence. The resection of the mesentery does not seem to reduce endoscopic and ultrasonographic recurrences, and the five-year recurrence rate.<\/jats:p>","DOI":"10.3390\/jcm11071961","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:22:39Z","timestamp":1648848159000},"page":"1961","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Has the Removing of the Mesentery during Ileo-Colic Resection an Impact on Post-Operative Complications and Recurrence in Crohn\u2019s Disease? Results from the Resection of the Mesentery Study (Remedy)"],"prefix":"10.3390","volume":"11","author":[{"given":"Michela","family":"Mineccia","sequence":"first","affiliation":[{"name":"Division of General and Oncologic Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Maconi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, ASST Fatebenefratelli-Sacco, via G.B. Grassi 74, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Daperno","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-6422","authenticated-orcid":false,"given":"Maria","family":"Cigognini","sequence":"additional","affiliation":[{"name":"Division of General Surgery, ASST Fatebenefratelli-Sacco, Ospedale, via G.B. Grassi 74, 20157 Milano, Italy"},{"name":"Division of General and HPB Surgery, ASST Rhodense, Rho Memorial Hospital, Corso Europa 250, 20017-Rho Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Division of General and Oncologic Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of General Surgery, ASST Fatebenefratelli-Sacco, Ospedale, via G.B. Grassi 74, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Perotti","sequence":"additional","affiliation":[{"name":"Division of General and Oncologic Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-3880","authenticated-orcid":false,"given":"Caterina","family":"Baldi","sequence":"additional","affiliation":[{"name":"Division of General Surgery, ASST Fatebenefratelli-Sacco, Ospedale, via G.B. Grassi 74, 20157 Milano, Italy"},{"name":"Division of General and HPB Surgery, ASST Rhodense, Rho Memorial Hospital, Corso Europa 250, 20017-Rho Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Massucco","sequence":"additional","affiliation":[{"name":"Division of General and Oncologic Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Ardizzone","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, ASST Fatebenefratelli-Sacco, via G.B. Grassi 74, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Division of General and Oncologic Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10128 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-441X","authenticated-orcid":false,"given":"Gianluca M.","family":"Sampietro","sequence":"additional","affiliation":[{"name":"Division of General Surgery, ASST Fatebenefratelli-Sacco, Ospedale, via G.B. 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