{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:15:52Z","timestamp":1791357352589,"version":"4.3.1"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Prader\u2013Willi syndrome (PWS) is a rare, genetic, multisymptomatic, neurodevelopmental disease commonly associated with sleep alterations, including sleep-disordered breathing and central disorders of hypersomnolence. Excessive daytime sleepiness represents the main manifestation that should be addressed by eliciting the detrimental effects on quality of life and neurocognitive function from the patients\u2019 caregivers. Patients with PWS have impaired ventilatory control and altered pulmonary mechanics caused by hypotonia, respiratory muscle weakness, scoliosis and obesity. Consequently, respiratory abnormalities are frequent and, in most cases, severe, particularly during sleep. Adults with PWS frequently suffer from sleep apnoea syndrome, sleep hypoxemia and sleep hypoventilation. When excessive daytime sleepiness persists after adequate control of sleep-disordered breathing, a sleep study on ventilatory treatment, followed by an objective measurement of excessive daytime sleepiness, is recommended. These tests frequently identify central disorders of hypersomnolence, including narcolepsy, central hypersomnia or a borderline hypersomnolent phenotype. The use of wake-enhancing drugs (modafinil, pitolisant) is discussed in multidisciplinary expert centres for these kinds of cases to ensure the right balance between the benefits on quality of life and the risk of psychological and cardiovascular side effects.<\/jats:p>","DOI":"10.3390\/jcm11071986","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T02:59:52Z","timestamp":1648954792000},"page":"1986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sleep Disorders in Adults with Prader\u2013Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre"],"prefix":"10.3390","volume":"11","author":[{"given":"Pauline","family":"Dodet","sequence":"first","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Narcolepsies et Hypersomnies Rares, Service des Pathologies du Sommeil (D\u00e9partement R3S), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"},{"name":"Institut du Cerveau (ICM), INSERM, CNRS, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sanapo","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Narcolepsies et Hypersomnies Rares, Service des Pathologies du Sommeil (D\u00e9partement R3S), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda","family":"Leu-Semenescu","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Narcolepsies et Hypersomnies Rares, Service des Pathologies du Sommeil (D\u00e9partement R3S), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"},{"name":"Institut du Cerveau (ICM), INSERM, CNRS, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8988-6260","authenticated-orcid":false,"given":"Muriel","family":"Coupaye","sequence":"additional","affiliation":[{"name":"Rare Diseases Center of Reference \u2018Prader-Willi Syndrome and Obesity with Eating Disorders\u2019 (PRADORT), Department of Nutrition, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-487X","authenticated-orcid":false,"given":"Alice","family":"Bellicha","sequence":"additional","affiliation":[{"name":"INSERM U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), Sorbonne Paris Nord University, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Narcolepsies et Hypersomnies Rares, Service des Pathologies du Sommeil (D\u00e9partement R3S), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"},{"name":"Institut du Cerveau (ICM), INSERM, CNRS, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Poitou","sequence":"additional","affiliation":[{"name":"Rare Diseases Center of Reference \u2018Prader-Willi Syndrome and Obesity with Eating Disorders\u2019 (PRADORT), Department of Nutrition, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"},{"name":"Nutrition and Obesities: Systemic Approaches (NutriOmics), INSERM, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Redolfi","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Narcolepsies et Hypersomnies Rares, Service des Pathologies du Sommeil (D\u00e9partement R3S), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, APHP-Sorbonne, 75013 Paris, France"},{"name":"UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, INSERM, Sorbonne University, 75005 Paris, France"},{"name":"Dipartimento di Scienze Mediche e Sanit\u00e0 Pubblica, Universit\u00e0 di Cagliari, 09134 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13023-017-0673-6","article-title":"Early diagnosis and care is achieved but should be improved in infants with Prader-Willi syndrome","volume":"12","author":"Bar","year":"2017","journal-title":"Orphanet J. 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