{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:33:02Z","timestamp":1781307182380,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Oligoasthenoteratozoospermia (OAT) accounts for about 90% of male infertility; in many cases this disorder may be associated with oxidative stress, a condition that decreases the success of fertilization. Therefore, the empirical treatment of male infertility is often based on the use of antioxidants. The aim of the present study was to assess the effectiveness of three months\u2019 administration of a new nutraceutical preparation on hormone profile, sperm parameters and fertilization capability in men undergoing in vitro fertilization (IVF). A total of 36 OAT patients were daily treated for 3 months with a dose of a formulation containing: Inositol, L-Carnitine, Vitamins C, D, E, Coenzyme Q10 and Selenium. Selected parameters were analysed before (T0) and after (T1) treatment, and IVF outcomes were evaluated. We observed an improvement of sperm concentration, motility, morphology and vitality; blood level of testosterone also showed an increase. A significant increase of fertilization rate was detected in 14 couples, whose male partner were treated with the nutraceutical preparation. The present results indicate that a formulation containing antioxidant and energy supply substances was effective in the treatment of sperm alterations and led to significant recovery of fertilizing capacity.<\/jats:p>","DOI":"10.3390\/jcm11071991","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T02:59:52Z","timestamp":1648954792000},"page":"1991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Positive Effect of a New Combination of Antioxidants and Natural Hormone Stimulants for the Treatment of Oligoasthenoteratozoospermia"],"prefix":"10.3390","volume":"11","author":[{"given":"Vincenzo","family":"De Leo","sequence":"first","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"},{"name":"Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tosti","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-2321","authenticated-orcid":false,"given":"Giuseppe","family":"Morgante","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"},{"name":"Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosetta","family":"Ponchia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"},{"name":"Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Luddi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-9548","authenticated-orcid":false,"given":"Laura","family":"Governini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-7028","authenticated-orcid":false,"given":"Paola","family":"Piomboni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy"},{"name":"Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.XHA.0000397686.82729.09","article-title":"Unexplained Male Infertility: Potential Causes and Management","volume":"1","author":"Hamada","year":"2011","journal-title":"Hum. 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