{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:59:42Z","timestamp":1780545582760,"version":"3.54.1"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Development Fund Regional (Feder) in accordance with the Operational Program of the Region of Castilla-La Mancha for Feder 2014-2020, and for the University of Castilla-La Mancha\u2019s own Research Plan.","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"Spanish Government (AEI), FEDER funds and the JCCM","award":["PID2019-106758GB-C33 \/AEI\/ 10.13039\/501100011033 and SBPLY\/17\/180501\/000493."],"award-info":[{"award-number":["PID2019-106758GB-C33 \/AEI\/ 10.13039\/501100011033 and SBPLY\/17\/180501\/000493."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The diagnosis of alcohol use disorder (AUD) remains a difficult challenge, and some patients may not be adequately diagnosed. This study aims to identify an optimum combination of laboratory markers to detect alcohol consumption, using data science. An analytical observational study was conducted with 337 subjects (253 men and 83 women, with a mean age of 44 years (10.61 Standard Deviation (SD)). The first group included 204 participants being treated in the Addictive Behaviors Unit (ABU) from Albacete (Spain). They met the diagnostic criteria for AUD specified in the Diagnostic and Statistical Manual of mental disorders fifth edition (DSM-5). The second group included 133 blood donors (people with no risk of AUD), recruited by cross-section. All participants were also divided in two groups according to the WHO classification for risk of alcohol consumption in Spain, that is, males drinking more than 28 standard drink units (SDUs) or women drinking more than 17 SDUs. Medical history and laboratory markers were selected from our hospital\u2019s database. A correlation between alterations in laboratory markers and the amount of alcohol consumed was established. We then created three predicted models (with logistic regression, classification tree, and Bayesian network) to detect risk of alcohol consumption by using laboratory markers as predictive features. For the execution of the selection of variables and the creation and validation of predictive models, two tools were used: the scikit-learn library for Python, and the Weka application. The logistic regression model provided a maximum AUD prediction accuracy of 85.07%. Secondly, the classification tree provided a lower accuracy of 79.4%, but easier interpretation. Finally, the Naive Bayes network had an accuracy of 87.46%. The combination of several common biochemical markers and the use of data science can enhance detection of AUD, helping to prevent future medical complications derived from AUD.<\/jats:p>","DOI":"10.3390\/jcm11072061","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T16:21:30Z","timestamp":1649262090000},"page":"2061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Common Laboratory Parameters Are Useful for Screening for Alcohol Use Disorder: Designing a Predictive Model Using Machine Learning"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-1957","authenticated-orcid":false,"given":"Juana","family":"Pinar-Sanchez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Jose Maria Morales Meseguer University General Hospital, 30008 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-910X","authenticated-orcid":false,"given":"Pablo","family":"Bermejo L\u00f3pez","sequence":"additional","affiliation":[{"name":"Computer Science Department, Universidad de Castilla-La Mancha, 02071 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-2090","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Sol\u00eds Garc\u00eda Del Pozo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Internal Medicine, University General Hospital of Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Redondo-Ruiz","sequence":"additional","affiliation":[{"name":"Unit and Gerodontology, Department of Dermatology, Stomatology, Radiology and Physical Medicine, Special Care Dentistry, Jose Maria Morales Meseguer University General Hospital, Faculty of Medicine, University of Murcia, 30008 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Navarro Casado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University General Hospital of Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Andres-Pretel","sequence":"additional","affiliation":[{"name":"Clinical Research Support Unit, National Paraplegics Hospital of Toledo Foundation, 45004 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Celorrio Bustillo","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Addictive Conducts Unit Care in Albacete, 02005 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Esparcia Moreno","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Addictive Conducts Unit Care in Albacete, 02005 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Garc\u00eda Ruiz","sequence":"additional","affiliation":[{"name":"Blood Donation Center from Albacete and Cuenca, Department of Hematology, University General Hospital of Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Javier","family":"Solera Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University General Hospital of Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Navarro Bravo","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, Universidad de Castilla-La Mancha, 02008 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJMcp1204714","article-title":"Alcohol use in adults","volume":"368","author":"Friedmann","year":"2013","journal-title":"N. 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