{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:46:39Z","timestamp":1767015999521,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007088","name":"Jagiellonian University","doi-asserted-by":"publisher","award":["N41\/DBS\/000038","N41\/DBS\/000437"],"award-info":[{"award-number":["N41\/DBS\/000038","N41\/DBS\/000437"]}],"id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background. The resistive (RI) and pulsatile (PI) indices are markers of vascular stiffness (VS) which are associated with outcomes in patients with cardiovascular disease. We aimed to assess whether VS might predict incidence of cardiovascular death (CVD) and heart failure (HF) episodes following intervention on degenerative aortic valve stenosis (DAS). Methods. The distribution of increased VS (RI \u2265 0.7 and PI \u2265 1.3) from supra-aortic arteries was assessed in patients with symptomatic DAS who underwent aortic valve replacement (AVR, n = 127) or transcatheter aortic valve implantation (TAVI, n = 119). During a 3-year follow-up period (FU), incidences of composite endpoint (CVD and HF) were recorded. Results. Increased VS was found in 100% of TAVI patients with adverse event vs. 88.9% event-free TAVI patients (p = 0.116), and in 93.3% of AVR patients with event vs. 70.5% event-free (p = 0.061). Kaplan\u2013Mayer free-survival curves at 1-year and 3-year FU were 90.5% vs. 97.1 % and 78% vs. 97.1% for patients with increased vs. lower VS. (p = 0.014). In univariate Cox analysis, elevated VS (HR 7.97, p = 0.04) and age (HR 1.05, p = 0.024) were associated with risk of adverse outcomes; however, both failed in Cox multivariable analysis. Conclusions. Vascular stiffness is associated with outcome after DAS intervention. However, it cannot be used as an independent outcome predictor.<\/jats:p>","DOI":"10.3390\/jcm11082078","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T13:39:51Z","timestamp":1649338791000},"page":"2078","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Increased Vascular Stiffness with Cardiovascular Death and Heart Failure Episodes Following Intervention on Symptomatic Degenerative Aortic Stenosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-1468","authenticated-orcid":false,"given":"Jakub","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-7840","authenticated-orcid":false,"given":"Anna","family":"Kablak-Ziembicka","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"Noninvasive Cardiovascular Laboratory, The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-8739","authenticated-orcid":false,"given":"Pawel","family":"Kleczynski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"Alfieri","sequence":"additional","affiliation":[{"name":"San Raffaele University Hospital and Alfieri Heart Foundation, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9652-165X","authenticated-orcid":false,"given":"\u0141ukasz","family":"Niewiara","sequence":"additional","affiliation":[{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"Department of Emergency Medicine, Faculty of Health Sciences, Jagiellonian University Medical College, 31-126 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-1318","authenticated-orcid":false,"given":"Rafa\u0142","family":"Badacz","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Pieniazek","sequence":"additional","affiliation":[{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, the John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Legutko","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Zmudka","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Przewlocki","sequence":"additional","affiliation":[{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, the John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-3428","authenticated-orcid":false,"given":"Jakub","family":"Podolec","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"},{"name":"The John Paul II Hospital, Pr\u0105dnicka 80 Str., 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"ref_1","first-page":"953","article-title":"Simple clinical scores to predict blood pressure and renal function response to renal artery stenting for atherosclerotic renal artery stenosis","volume":"130","author":"Badacz","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5603\/MRJ.a2020.0016","article-title":"Clinical application of pulsatility index","volume":"52","author":"Wielicka","year":"2020","journal-title":"Med. Res. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1161\/CIRCULATIONAHA.104.483628","article-title":"Health ABC Study. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults","volume":"111","author":"Najjar","year":"2005","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1097\/HJH.0b013e328361e4bd","article-title":"Early vascular ageing in translation: From laboratory investigations to clinical applications in cardiovascular prevention","volume":"31","author":"Nilsson","year":"2013","journal-title":"J. Hypertens."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","article-title":"Association Between Cardiovascular Risk Factors and Aortic Stenosis: The CANHEART Aortic Stenosis Study","volume":"69","author":"Yan","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","first-page":"615","article-title":"Serum rantes, transforming growth factor-\u03b21 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis","volume":"69","author":"Podolec","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Severino, P., D\u2019Amato, A., Prosperi, S., Magnocavallo, M., Mariani, M.V., Netti, L., Birtolo, L.I., De Orchi, P., Chimenti, C., and Maestrini, V. (2021). Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8090116"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2021.07.006","article-title":"Arterial biomarkers in the evaluation, management, and prognosis of aortic stenosis","volume":"332","author":"Gardikioti","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/HJH.0000000000001940","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: A focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.STR.32.4.836","article-title":"Comparison of carotid arterial resistive indices with intima-media thickness as sonographic markers of atherosclerosis","volume":"32","author":"Frauchiger","year":"2001","journal-title":"Stroke"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Baran, J., Kleczy\u0144ski, P., Niewiara, \u0141., Podolec, J., Badacz, R., Gackowski, A., Pieni\u0105\u017cek, P., Legutko, J., \u017bmudka, K., and Przew\u0142ocki, T. (2021). Importance of Increased Arterial Resistance in Risk Prediction in Patients with Cardiovascular Risk Factors and Degenerative Aortic Stenosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102109"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J.C., and M\u00fcller, M. (2011). pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinf., 12.","DOI":"10.1186\/1471-2105-12-77"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1910555","article-title":"PARTNER 2 Investigators. Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement","volume":"382","author":"Makkar","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","first-page":"774","article-title":"Risk factors for congestive heart failure after aortic valve replacement with a Carpentier-Edwards pericardial prosthesis in the elderly","volume":"14","author":"Mistiaen","year":"2005","journal-title":"J. Heart Valve Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/ehf2.13774","article-title":"HFA-PEFF score: Prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation","volume":"9","author":"Seoudy","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Severino, P., D\u2019Amato, A., Prosperi, S., Fanisio, F., Birtolo, L.I., Costi, B., Netti, L., Chimenti, C., Lavalle, C., and Maestrini, V. (2021). Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147650"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/ehf2.13451","article-title":"Prognosis and outcome determinants after heart failure diagnosis in patients who underwent aortic valvular intervention","volume":"8","author":"Kontogeorgos","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2020.03.081","article-title":"Determinants and clinical significance of aortic stiffness in patients with moderate or severe aortic stenosis","volume":"315","author":"Saeed","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/heartjnl-2019-315908","article-title":"Left ventricular filling pressure and survival following aortic valve replacement for severe aortic stenosis","volume":"106","author":"Thaden","year":"2020","journal-title":"Heart"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jjcc.2021.01.007","article-title":"Prognostic impact of arterial stiffness following transcatheter aortic valve replacement","volume":"78","author":"Tanaka","year":"2021","journal-title":"J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1097\/HJH.0000000000002141","article-title":"Pulse wave velocity can be accurately measured during transcatheter aortic valve implantation and used for post-procedure risk stratification","volume":"37","author":"Broyd","year":"2019","journal-title":"J. Hypertens."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12968-016-0256-z","article-title":"Assessment of aortic stiffness by cardiovascular magnetic resonance following the treatment of severe aortic stenosis by TAVI and surgical AVR","volume":"18","author":"Musa","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijcard.2020.08.040","article-title":"The impact of transcatheter aortic valve implantation on arterial stiffness and wave reflections","volume":"323","author":"Gardikioti","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/clc.22684","article-title":"Transcatheter aortic valve implantation improves carotid and vertebral arterial blood flow in patients with severe aortic stenosis: Practical role of orthostatic stress test","volume":"40","author":"Dziewierz","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5761\/atcs.oa.17-00062","article-title":"Changes in Aortic Pulse Wave Velocity and the Predictors of Improvement in Arterial Stiffness Following Aortic Valve Replacement","volume":"23","author":"Karaca","year":"2017","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"ref_28","first-page":"2","article-title":"Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement","volume":"91","author":"Kidher","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_29","first-page":"276","article-title":"Increased risk profile in the treatment of patients with symptomatic degenerative aortic valve stenosis over the last 10 years","volume":"14","author":"Baran","year":"2018","journal-title":"Adv. Interv. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"E544","DOI":"10.1002\/ccd.29130","article-title":"Clinical risk model for predicting 1-year mortality after transcatheter aortic valve replacement","volume":"97","author":"Yamamoto","year":"2021","journal-title":"Cath. Cardiovasc. Interv."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Jonik, S., Marchel, M., P\u0119dzich-Placha, E., Huczek, Z., Kochman, J., \u015acis\u0142o, P., Czub, P., Wilimski, R., Hendzel, P., and Opolski, G. (2021). Heart Team for Optimal Management of Patients with Severe Aortic Stenosis-Long-Term Outcomes and Quality of Life from Tertiary Cardiovascular Care Center. J. Clin. Med., 10.","DOI":"10.3390\/jcm10225408"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pighi, M., Giovannini, D., Scarsini, R., and Piazza, N. (2021). Diagnostic Work-Up of the Aortic Patient: An Integrated Approach toward the Best Therapeutic Option. J. Clin. Med., 10.","DOI":"10.3390\/jcm10215120"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ciardetti, N., Ciatti, F., Nardi, G., Di Muro, F.M., Demola, P., Sottili, E., Stolcova, M., Ristalli, F., Mattesini, A., and Meucci, F. (2021). Advancements in Transcatheter Aortic Valve Implantation: A Focused Update. Medicina, 57.","DOI":"10.3390\/medicina57070711"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/8\/2078\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:49:52Z","timestamp":1760136592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/8\/2078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcm11082078"],"URL":"https:\/\/doi.org\/10.3390\/jcm11082078","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,4,7]]}}}