{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:01:17Z","timestamp":1761562877011,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 \u00b1 10 years, preoperative body mass index [BMI] 41.8 \u00b1 5 kg\/m2) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS\/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 \u00b1 3.9 kg\/m2 in BMI, 0.5 \u00b1 1.9 mm in AWT, 2.6 \u00b1 2.3 mm in pericardial fat, and 45%\/53% in AVS\/MVS (p &lt; 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p &lt; 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p &lt; 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI &lt; 28 kg\/m2.<\/jats:p>","DOI":"10.3390\/jcm11082237","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T04:21:28Z","timestamp":1650255688000},"page":"2237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery"],"prefix":"10.3390","volume":"11","author":[{"given":"Nina","family":"Kovac","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M. D.","family":"Grymyr","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Gerdts","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saied","family":"Nadirpour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haugesund Hospital, 5528 Haugesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn G.","family":"Nedreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Medicine, Haugesund Hospital, 5528 Haugesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes J.","family":"Hjertaas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haugesund Hospital, 5528 Haugesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Matre","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Cramariuc","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"ref_1","first-page":"437","article-title":"Atherosclerosis in youth","volume":"54","author":"McGill","year":"2002","journal-title":"Minerva Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrcardio.2009.55","article-title":"Obesity, inflammation, and atherosclerosis","volume":"6","author":"Rocha","year":"2009","journal-title":"Nat. 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