{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:41:32Z","timestamp":1790444492521,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hallym University Research Fund 2019","award":["HURF-2019-38"],"award-info":[{"award-number":["HURF-2019-38"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Thalassemia is the most common form of hereditary anemia. Here, we aimed to investigate the 13-year trend of the epidemiologic profiles and risk of comorbidities in thalassemia using a nationwide population-based registry in Korea. Diagnosis of thalassemia, the comorbidities and transfusion events in patients with thalassemia were identified in the Korean National Health Insurance database, which includes the entire population. The prevalence of thalassemia increased from 0.74\/100,000 in 2006 to 2.76\/100,000 in 2018. Notably, the incidence rate has nearly doubled in the last 2 years from 0.22\/100,000 in 2016 to 0.41\/100,000 in 2018. The annual transfusion rate gradually decreased from 34.7% in 2006 to 20.6% in 2018. Transfusion events in patients with thalassemia were significantly associated with the risk of comorbidities (diabetes: odds ratio [OR] = 3.68, 95% confidence interval [CI] = 2.59\u20135.22; hypertension: OR = 3.06, 95% CI = 2.35\u20134.00; dyslipidemia: OR = 1.72, 95% CI = 1.22\u20132.43; atrial fibrillation: OR = 3.52, 95% CI = 1.69\u20137.32; myocardial infarction: OR = 3.02, 95% CI = 1.09\u20138.38; stroke: OR = 3.32, 95% CI = 2.05\u20135.36; congestive heart failure: OR = 2.83, 95% CI = 1.62\u20134.97; end-stage renal disease: OR = 3.25, 95% CI = 1.96\u20135.37). Early detection of comorbidities and timely intervention are required for the management of thalassemia.<\/jats:p>","DOI":"10.3390\/jcm11092289","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:46:11Z","timestamp":1650512771000},"page":"2289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epidemiologic Trends of Thalassemia, 2006\u20132018: A Nationwide Population-Based Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Jee-Soo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Seoul National University Hospital, Seoul 03080, Korea"},{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Min","family":"Rhee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibum","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hangang Sacred Heart Hospital, Seoul 07247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-4318","authenticated-orcid":false,"given":"Yonggeun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-8219","authenticated-orcid":false,"given":"Seung-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Woo","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul National University Hospital, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Sup","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul National University Hospital, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Korea"},{"name":"Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"s28","DOI":"10.1179\/102453312X13336169155295","article-title":"Thalassemia","volume":"17","author":"Aydinok","year":"2012","journal-title":"Hematology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Goh, L.P.W., Chong, E.T.J., and Lee, P.-C. 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