{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:25:06Z","timestamp":1772252706290,"version":"3.50.1"},"reference-count":132,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (1H-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and 1H-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.<\/jats:p>","DOI":"10.3390\/jcm11092301","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:46:11Z","timestamp":1650512771000},"page":"2301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-4990","authenticated-orcid":false,"given":"Jan","family":"Valo\u0161ek","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc, 779 00 Olomouc, Czech Republic"},{"name":"Department of Radiology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc, 779 00 Olomouc, Czech Republic"},{"name":"Department of Biomedical Engineering, University Hospital Olomouc, 779 00 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-7661","authenticated-orcid":false,"given":"Petr","family":"Bedna\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, 2650 Hvidovre, Denmark"},{"name":"Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, 2650 Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo\u0161","family":"Ke\u0159kovsk\u00fd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"},{"name":"Department of Radiology and Nuclear Medicine, University Hospital Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-0671","authenticated-orcid":false,"given":"Petr","family":"Hlu\u0161t\u00edk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc, 779 00 Olomouc, Czech Republic"},{"name":"Department of Neurology, University Hospital Olomouc, 779 00 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-2383","authenticated-orcid":false,"given":"Josef","family":"Bedna\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"},{"name":"Department of Neurology, University Hospital Brno, 625 00 Brno, Czech Republic"},{"name":"Central European Institute of Technology, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-4280","authenticated-orcid":false,"given":"Alena","family":"Svatkova","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, 2650 Hvidovre, Denmark"},{"name":"Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, 2650 Hvidovre, Denmark"},{"name":"Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41582-019-0303-0","article-title":"Degenerative cervical myelopathy\u2014Update and future directions","volume":"16","author":"Badhiwala","year":"2020","journal-title":"Nat. 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