{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:55:12Z","timestamp":1776495312028,"version":"3.51.2"},"reference-count":13,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: To assess the impact of total thyroidectomy on thyroid function. Methods: Monocentric observational prospective study. Patients who benefited from a total thyroidectomy in the Department of Otolaryngology-Head and Neck Surgery between September 2017 and July 2019 were included. Three blood samples were taken from each patient during the perioperative period: preoperatively (T0), intraoperatively (T1), and postoperatively (T2). Changes in TSH, T4, T3, and thyroglobulin levels were evaluated from T0 to T2. Epidemiological data were retrieved from the medical charts. Statistical analyses were performed for the entire cohort and subgroups regarding preoperative treatment and type of disease. Results: Seventy-seven patients were included in the study. T4 and thyroglobulin levels increased significantly from T0 to T1. TSH, T4, T3, and thyroglobulin levels decreased significantly from T1 to T2. Conclusions: Our study confirmed the hypothesis of variable kinetics of thyroid hormone levels associated with the manipulation of the thyroid gland during surgery, but none of these changes resulted in clinical effects, including thyrotoxicosis.<\/jats:p>","DOI":"10.3390\/jcm11092416","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"2416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in TSH, T4, T3 and Thyroglobulin Levels throughout Total Thyroidectomy"],"prefix":"10.3390","volume":"11","author":[{"given":"Nora","family":"Senese","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head & Neck surgery, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head & Neck surgery, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"},{"name":"Department of Thoracic-Head & Neck Surgery, Centre Oscar Lambret, 59000 Lille, France"},{"name":"Laboratory of Human Anatomy and Experimental Oncology, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head & Neck surgery, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head & Neck surgery, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"},{"name":"Department of Stomatology-Maxillofacial Surgery, CHU Saint Pierre, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ecl.2018.11.003","article-title":"Conventional Thyroidectomy in the Treatment of Primary Thyroid Cancer","volume":"48","author":"Roman","year":"2019","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_2","first-page":"707","article-title":"\u00c9volution r\u00e9cente de la chirurgie thyro\u00efdienne","volume":"1","author":"Peix","year":"2017","journal-title":"Bull. Acad. Natl. M\u00e9d."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000478927","article-title":"European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS","volume":"6","author":"Russ","year":"2017","journal-title":"Eur. Thyroid J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40463-018-0281-z","article-title":"A retrospective cohort study: Do patients with graves\u2019 disease need to be euthyroid prior to surgery?","volume":"47","author":"Wallace","year":"2018","journal-title":"J. Otolaryngol. 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J."},{"key":"ref_11","first-page":"219","article-title":"Lacking evidence for relaese of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy","volume":"117","author":"Date","year":"1988","journal-title":"Acta Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0026-0495(88)90090-X","article-title":"Sequential changes in serum thyrogloblin, triiodothyronine, and thyroxine following partial thyroidectomy for nontoxic nodular goiter","volume":"37","author":"Shigemasa","year":"1988","journal-title":"Metabolism"},{"key":"ref_13","first-page":"131","article-title":"Changes in serum thyroid hormone and thyroglobulin levels after surgical treatments for toxic and non-toxic goiter","volume":"1","author":"Lee","year":"1989","journal-title":"Thyroidology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/9\/2416\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:01:00Z","timestamp":1760137260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/9\/2416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["jcm11092416"],"URL":"https:\/\/doi.org\/10.3390\/jcm11092416","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]}}}