{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:59:45Z","timestamp":1788893985876,"version":"build-2803163510"},"reference-count":67,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In recent years, antioxidant supplements have become popular to counteract the effects of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of this systematic review was to summarize the effects of antioxidant supplementation on pain levels perceived by patients diagnosed with fibromyalgia. The words used respected the medical search terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation. Seventeen relevant articles were identified within Medline (PubMed), Scopus, Web of Science (WOS), the Cochrane Database of Systematic Review, and the Cochrane Central Register of Controlled Trials. This review found that antioxidant supplementation is efficient in reducing pain in nine of the studies reviewed. Studies with a duration of supplementation of at least 6 weeks showed a benefit on pain perception in 80% of the patients included in these studies. The benefits shown by vitamins and coenzyme Q10 are remarkable. Further research is needed to identify the effects of other types of antioxidants, such as extra virgin olive oil and turmeric. More homogeneous interventions in terms of antioxidant doses administered and duration would allow the effects on pain to be addressed more comprehensively.<\/jats:p>","DOI":"10.3390\/jcm11092462","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"2462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia\u2014A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-1014","authenticated-orcid":false,"given":"Ana","family":"Fern\u00e1ndez-Araque","sequence":"first","affiliation":[{"name":"Research Group Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, Department of Nursing, Faculty of Health Sciences, University of Valladolid, Campus of Soria, 42003 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-7672","authenticated-orcid":false,"given":"Zoraida","family":"Verde","sequence":"additional","affiliation":[{"name":"Research Group Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, Department of Nursing, Faculty of Health Sciences, University of Valladolid, Campus of Soria, 42003 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Torres-Ortega","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences, University of Valladolid, 42005 Soria, Spain"},{"name":"Emergency Service of the Hospital Santa B\u00e1rbara, Soria Healthcare Management, 42005 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-055X","authenticated-orcid":false,"given":"Maria","family":"Sainz-Gil","sequence":"additional","affiliation":[{"name":"Recognized Research Group \u201cPharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology\u201d, Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Center for Drug Safety Studies, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-9760","authenticated-orcid":false,"given":"Veronica","family":"Velasco-Gonzalez","sequence":"additional","affiliation":[{"name":"Research Group Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, Department of Nursing, Faculty of Health Sciences, University of Valladolid, Campus of Soria, 42003 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7298-9060","authenticated-orcid":false,"given":"Jer\u00f3nimo Javier","family":"Gonz\u00e1lez-Bernal","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-4602","authenticated-orcid":false,"given":"Juan","family":"Mielgo-Ayuso","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/berh.1999.0032","article-title":"Is fibromyalgia a distinct clinical entity? 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