{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:24Z","timestamp":1787028624683,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Juvenile idiopathic arthritis (JIA) is a rheumatic condition of childhood that is frequently associated with anterior chronic uveitis. Evidence suggests that uveitis may persist up to adulthood in some cases, possibly causing severe visual impairment. Methods: We conducted a retrospective study on a series of patients aged 16 years or older with JIA-related active uveitis who were referred to the Uveitis Service of Sapienza University of Rome from 1990 to 2019 to evaluate the characteristics of ocular disease in patients with JIA-associated uveitis (JIA-U) who still exhibit uveitis in adulthood. Data on clinical features, treatment, complications and visual outcomes were collected. Results: Twenty adults (85% female; median age 23.4 \u00b1 6.6 years, range 16\u201338 years) with ongoing uveitis (35 eyes) were identified. The median age at JIA onset was 6.15 \u00b1 2.9 years (range 2\u201310), and uveitis onset was 8.7 \u00b1 4.7 years (range 3\u201320). The patients were observed in a median follow-up of 16 \u00b1 7.7 years (range 4\u201335). Fifty-seven percent of affected eyes (20 eyes) had good visual acuity (&gt;0.4 logMAR), while eleven percent of affected eyes (4 eyes) were blind (\u226420\/200). Uveitis required topical steroids and mydriatic\/cycloplegic in all cases. Orbital steroid injection was performed in 13 eyes. Systemic corticosteroids and biologic drugs were used in 14 patients. Conclusions: Although the visual prognosis of JIA-U has improved in recent years, persistent uveitis up to adulthood is still observed. Therefore, protracted follow-up of JIA-U patients is warranted because of the high burden of delayed visual complications.<\/jats:p>","DOI":"10.3390\/jcm11092471","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T22:20:06Z","timestamp":1651184406000},"page":"2471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Persistence of Juvenile Idiopathic Arthritis-Associated Uveitis in Adulthood: A Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-4774","authenticated-orcid":false,"given":"Maria Pia","family":"Paroli","sequence":"first","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-4823","authenticated-orcid":false,"given":"Alessandro","family":"Abbouda","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-1455","authenticated-orcid":false,"given":"Massimo","family":"Accorinti","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Falcione","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Spadea","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Eye Clinic, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-9128","authenticated-orcid":false,"given":"Marino","family":"Paroli","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Department of Clinical, Anestesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref_1","first-page":"92","article-title":"Uveitis in juvenile idiopathic arthritis","volume":"112","author":"Heiligenhaus","year":"2015","journal-title":"Dtsch. 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