{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:25:13Z","timestamp":1789683913153,"version":"4.0.1"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Istituto Stomatologico Toscano, Foundation for Research, Via Aurelia 335, 55041 Lido di Camaiore (LU)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The healing process of the tooth extraction socket often leads to significant resorption of the alveolar bone, eventually causing clinical difficulties for future implant-supported rehabilitations. The aim of the present animal study was to evaluate alveolar bone remodeling after tooth extraction in a rabbit model, either with or without the use of a plain collagen plug inside the socket, by means of micro-computed tomography. The study included the micro-tomography analysis of 36 rabbits\u2019 incisor extraction sockets, either left empty or filled with a collagen plug. All animals were euthanized in a staggered manner, in order to address molecular, histologic, and radiographic analyses at different time-points, up to 90 days after surgery. The three-dimensional evaluation was carried out using micro-computed tomography technology on excised bone blocks including the alveolus and the contralateral bone. Both linear and volumetric measures were recorded: the percentage of bone volume change (\u0394BV) within the region of interest was considered the primary endpoint of the study. The micro-CT analysis revealed mean volumetric changes of \u221258.1% \u00b1 from baseline to 3 months for the control group, and almost no bone loss for the test group, \u22124.6%. The sockets treated with the collagen plug showed significantly less dimensional resorption, while the natural-healing group showed an evident collapse of the alveolar bone three months after extraction surgery.<\/jats:p>","DOI":"10.3390\/jcm11092493","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"2493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Alveolar Bone Remodeling with or without Collagen Filling of the Extraction Socket: A High-Resolution X-ray Tomography Animal Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Ugo","family":"Covani","sequence":"first","affiliation":[{"name":"Istituto Stomatologico Toscano, Via Aurelia 335, 55041 Lido di Camaiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-8525","authenticated-orcid":false,"given":"Enrica","family":"Giammarinaro","sequence":"additional","affiliation":[{"name":"Istituto Stomatologico Toscano, Via Aurelia 335, 55041 Lido di Camaiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Panetta","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology (CNR-IFC), Via G. Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-1059","authenticated-orcid":false,"given":"Piero A.","family":"Salvadori","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology (CNR-IFC), Via G. Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-8011","authenticated-orcid":false,"given":"Saverio","family":"Cosola","sequence":"additional","affiliation":[{"name":"Istituto Stomatologico Toscano, Via Aurelia 335, 55041 Lido di Camaiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Marconcini","sequence":"additional","affiliation":[{"name":"Istituto Stomatologico Toscano, Via Aurelia 335, 55041 Lido di Camaiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/0022-3913(63)90225-7","article-title":"Postextraction changes in the adult mandible as illustrated by microradiographs of midsagittal sections and serial cephalometric roentgenograms","volume":"13","author":"Atwood","year":"1963","journal-title":"J. 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