{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:27:45Z","timestamp":1781893665854,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sheba-Gertner Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>COVID-19 infection imposes a risk for pregnant individuals and may lead to adverse maternal and obstetric outcomes. This is a retrospective cohort study of all women giving birth between March and July 2021 at a single tertiary center. Obstetric and neonatal outcomes were compared between vaccinated and non-vaccinated pregnant women with singleton pregnancies. Women with prior COVID-19 infection, multiple gestations and stillbirth were excluded from the study. Of 4708 women who delivered during the study period, 3700 met the eligibility criteria, of whom 3240 were vaccinated during pregnancy. Compared with the non-vaccinated group, the vaccinated group was characterized by a lower rate of smoking (3.70% vs. 6.67%, p = 0.0028), whereasother maternal characteristics were not significantly different. Multivariable analysis demonstrated that COVID-19 mRNA vaccination was not significantly associated with increased risk of preterm birth as well as other adverse obstetric outcomes including hypertensive diseases of pregnancy, cesarean delivery and small for gestational age. However, a significantly lower risk for meconium-stained amniotic fluid was observed among the vaccinated group (adjusted odds ratio 0.63; 95% confidence interval, 0.46\u20130.86, p = 0.0039). Moreover, the vaccine was not significantly associated with increased risk of neonatal adverse outcomes including respiratory complications and NICU hospitalization. In conclusion, BNT162b2 messenger RNA vaccination during pregnancy was not associated with an increased rate of adverse obstetric and neonatal outcomes. Therefore, in view of its safety on one hand, and the risk associated with COVID-19 disease in pregnancy on the other hand, BNT 162b2 COVID-19 vaccine should be recommended for pregnant women.<\/jats:p>","DOI":"10.3390\/jcm11092540","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T06:23:08Z","timestamp":1651386188000},"page":"2540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Obstetric and Neonatal Outcomes following COVID-19 Vaccination in Pregnancy"],"prefix":"10.3390","volume":"11","author":[{"given":"Ravit","family":"Peretz-Machluf","sequence":"first","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Hirsh-Yechezkel","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Unit, Gertner Institute for Epidemiology & Health Policy Research Ltd., Tel Hashomer, Ramat Gan 5266202, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Zaslavsky-Paltiel","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Unit, Gertner Institute for Epidemiology & Health Policy Research Ltd., Tel Hashomer, Ramat Gan 5266202, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Farhi","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Unit, Gertner Institute for Epidemiology & Health Policy Research Ltd., Tel Hashomer, Ramat Gan 5266202, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Avisar","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-1304","authenticated-orcid":false,"given":"Liat","family":"Lerner-Geva","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"Women and Children\u2019s Health Research Unit, Gertner Institute for Epidemiology & Health Policy Research Ltd., Tel Hashomer, Ramat Gan 5266202, Israel"},{"name":"School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Meyer","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Tsur","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-370X","authenticated-orcid":false,"given":"Yoav","family":"Yinon","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.mayocp.2020.05.011","article-title":"SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review","volume":"95","author":"Narang","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100446","DOI":"10.1016\/j.eclinm.2020.100446","article-title":"SARS-CoV-2 Infection in Pregnancy: A Systematic Review and Meta-Analysis of Clinical Features and Pregnancy Outcomes","volume":"25","author":"Khalil","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","article-title":"Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status\u2014United States, January 22\u2013October 3, 2020","volume":"69","author":"Zambrano","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E540","DOI":"10.1503\/cmaj.202604","article-title":"The Impact of COVID-19 on Pregnancy Outcomes: A Systematic Review and Meta-Analysis","volume":"193","author":"Wei","year":"2021","journal-title":"CMAJ"},{"key":"ref_5","unstructured":"(2021, November 16). The Food and Drug administration, Available online: https:\/\/www.fda.gov\/emergency-preparedness-and-response\/coronavirus-disease-2019-covid-19\/comirnaty-and-pfizer-biontech-covid-19-vaccine."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 MRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa2101765","article-title":"BNT162b2 MRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting","volume":"384","author":"Dagan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_8","unstructured":"(2021, November 16). CDC Vaccination Considerations for People Pregnant or Breastfeeding, Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/recommendations\/pregnancy.html."},{"key":"ref_9","unstructured":"(2021, November 16). ACOG COVID-19 Vaccination Considerations for Obstetric\u2013Gynecologic Care. Available online: https:\/\/www.acog.org\/en\/clinical\/clinical-guidance\/practice-advisory\/articles\/2020\/12\/covid-19-vaccination-considerations-for-obstetric-gynecologic-care."},{"key":"ref_10","unstructured":"(2021, November 16). MOH Vaccinating Women Who Are Planning a Pregnancy, Pregnant or Breastfeeding with the COVID-19 Vaccine\u2013Clarification, Available online: https:\/\/www.gov.il\/en\/departments\/news\/28012021-03."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1056\/NEJMoa2104983","article-title":"Preliminary Findings of MRNA Covid-19 Vaccine Safety in Pregnant Persons","volume":"384","author":"Shimabukuro","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1001\/jama.2021.11035","article-title":"Association Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women","volume":"326","author":"Goldshtein","year":"2021","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41591-021-01490-8","article-title":"Effectiveness of the BNT162b2 MRNA COVID-19 Vaccine in Pregnancy","volume":"27","author":"Dagan","year":"2021","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303.e1","DOI":"10.1016\/j.ajog.2021.03.023","article-title":"Coronavirus Disease 2019 Vaccine Response in Pregnant and Lactating Women: A Cohort Study","volume":"225","author":"Gray","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"236.e1","DOI":"10.1016\/j.ajog.2021.08.007","article-title":"COVID-19 Vaccination during Pregnancy: Coverage and Safety","volume":"226","author":"Blakeway","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/jama.2021.15494","article-title":"Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy","volume":"326","author":"Kharbanda","year":"2021","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMc2113891","article-title":"Receipt of MRNA Covid-19 Vaccines and Risk of Spontaneous Abortion","volume":"385","author":"Zauche","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1056\/NEJMc2114466","article-title":"Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage","volume":"385","author":"Magnus","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/uog.23729","article-title":"Short-Term Outcome of Pregnant Women Vaccinated with BNT162b2 MRNA COVID-19 Vaccine","volume":"58","author":"Regev","year":"2021","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.ajogmf.2021.100492","article-title":"Maternal-Neonatal Transfer of SARS-CoV-2 Immunoglobulin G Antibodies among Parturient Women Treated with BNT162b2 Messenger RNA Vaccine during Pregnancy","volume":"4","author":"Nir","year":"2022","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.15585\/mmwr.mm7101e1","article-title":"Receipt of COVID-19 Vaccine During Pregnancy and Preterm or Small-for-Gestational-Age at Birth\u2014Eight Integrated Health Care Organizations, United States, December 15, 2020\u2013July 22, 2021","volume":"71","author":"Lipkind","year":"2022","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1016\/j.vaccine.2021.09.012","article-title":"Prenatal Maternal COVID-19 Vaccination and Pregnancy Outcomes","volume":"39","author":"Wainstock","year":"2021","journal-title":"Vaccine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/1471-0528.16941","article-title":"Covid-19 Vaccination during the Third Trimester of Pregnancy: Rate of Vaccination and Maternal and Neonatal Outcomes, a Multicentre Retrospective Cohort Study","volume":"129","author":"Rottenstreich","year":"2022","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1080\/14767058.2017.1410700","article-title":"Meconium Aspiration Syndrome: Risk Factors and Predictors of Severity","volume":"32","author":"Oliveira","year":"2019","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhang, P., Heyman, T., Greechan, M., Dygulska, B., Al Sayyed, F., Narula, P., and Lederman, S. (2021). Maternal, Neonatal and Placental Characteristics of SARS-CoV-2 Positive Mothers. J. Matern.-Fetal Neonatal Med., 1\u20139.","DOI":"10.1080\/14767058.2021.1892637"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.pedneo.2021.05.004","article-title":"Neonatal Outcomes of Pregnant Women with COVID-19 in a Developing Country Setup","volume":"62","author":"Nayak","year":"2021","journal-title":"Pediatr. Neonatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/9\/2540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:05:18Z","timestamp":1760137518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/9\/2540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["jcm11092540"],"URL":"https:\/\/doi.org\/10.3390\/jcm11092540","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,30]]}}}