{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T01:58:56Z","timestamp":1762048736527,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The purpose of the study was to explore factors associated with glaucomatous deterioration in eyes with primary angle closure (PAC) after lens extraction, including PAC suspect (PACS), PAC, and PAC glaucoma (PACG). We retrospectively analyzed data of 77 eyes with PACS, PAC, and PACG that underwent lens extraction with more than 2 years postoperative follow-up. Postoperative glaucoma progression was analyzed by either structural (optic disc\/retinal nerve fiber layer (RNFL) photographs or optical coherent tomography (OCT)) or functional (visual field (VF)) criterion. Cox proportional hazard analysis (hazard ratio (HR)) was used to determine risk factors for progression using uni-and multivariate analysis. The analysis was conducted in groups with or without glaucomatous optic neuropathy (PACS\/PAC vs. PACG). Forty-one eyes with PACS\/PAC and 36 eyes with PACG were included. The mean postoperative follow-up period was 3.5 \u00b1 1.4 years. Intraocular pressure (IOP) was reduced postoperatively from 23.1 \u00b1 14.4 to 13.4 \u00b1 2.1 mmHg. In the PACS\/PAC group, seven eyes (17.0%) showed structural progression, but none showed progression in VF. Preoperative RNFL thickness was the only risk factor for structural progression (HR = 0.928, p = 0.002) in the PACS\/PAC group. In the PACG group, 24 eyes (66.7%) showed structural progression and 12 eyes (33.3%) showed VF progression. Thinner preoperative RNFL thickness (HR = 0.964, p = 0.043) and high postoperative IOP fluctuation (HR = 1.296, p = 0.011) were significantly associated with VF progression; none of the factors were associated with structural progression. Angle closure eyes with thinner baseline RNFL thickness and higher postoperative IOP fluctuation may require careful follow-up for glaucoma progression after lens extraction.<\/jats:p>","DOI":"10.3390\/jcm11092557","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T07:08:58Z","timestamp":1651475338000},"page":"2557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Factors Associated with Deterioration of Primary Angle Closure after Lens Extraction"],"prefix":"10.3390","volume":"11","author":[{"given":"Min Kyung","family":"Song","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang 10380, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Rim","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1076\/soph.17.2.50.14718","article-title":"The epidemiology of primary angle closure and associated glaucomatous optic neuropathy","volume":"17","author":"Foster","year":"2002","journal-title":"Semin. 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