{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:46:04Z","timestamp":1791431164276,"version":"4.3.3"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Public Trust Foundation of Marumo ER Medicine &amp; Research Institute of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This is a prospective multicenter cohort study aiming to investigate the association between early mobilization (EM), defined as a rehabilitation level of sitting at the edge of the bed or higher within 72 h of ICU admission, and psychiatric outcome. Consecutive patients, admitted to the ICU for more than 48 h, were enrolled. The primary outcome was the incidence of psychiatric symptoms at 3 months after hospital discharge defined as the presence of any of three symptoms: depression, anxiety, or post-traumatic stress disorder (PTSD). Risk ratio (RR) and multiple logistic regression analysis were used. As a sensitivity analysis, two methods for inverse probability of treatment weighting statistics were performed. Of the 192 discharged patients, 99 (52%) were assessed. The patients who achieved EM had a lower incidence of psychiatric symptoms compared to those who did not (25% vs. 51%, p-value 0.008, odds ratio (OR) 0.27, adjusted p = 0.032). The RR for psychiatric symptoms in the EM group was 0.49 [95% Confidence Interval, 0.29\u20130.83]. Sensitivity analysis accounting for the influence of death, loss to follow-up (OR 0.28, adjusted p = 0.008), or potential confounders (OR 0.49, adjusted p = 0.046) consistently showed a lower incidence of psychiatric symptoms in the EM group. EM was consistently associated with fewer psychiatric symptoms.<\/jats:p>","DOI":"10.3390\/jcm11092587","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:10:26Z","timestamp":1651756226000},"page":"2587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association between Early Mobilization in the ICU and Psychiatric Symptoms after Surviving a Critical Illness: A Multi-Center Prospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Shinichi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, National Hospital Organization, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan"},{"name":"Department of Physical Therapy, Faculty of Rehabilitation, Gifu University of Health Science, 2-92 Higashiuzura, Gifu 500-8281, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-1420","authenticated-orcid":false,"given":"Keibun","family":"Liu","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, 627 Rode Rd, Chermside, QLD 4032, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-0294","authenticated-orcid":false,"given":"Kensuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 2-1-1 Jounann, Hitachi 317-0077, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-185X","authenticated-orcid":false,"given":"Ryo","family":"Kozu","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyou-cho, Nagasaki 852-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Horibe","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Tokyo Women\u2019s Medical University, 8-1 Kawata-cho, Shinjuku-ku, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care Unit, Fukuyama City Hospital, 3-8-5 Zao-cho, Fukuyama 721-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisetsu","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Naha City Hospital, 2-31-1 Furujima, Naha 902-8511, Japan"},{"name":"Department of Healthcare Administration, The University of Kyushu, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Yuuai Medical Center, 50-5 Yone, Tomigusuku 901-0224, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Nanba","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Yao Tokushukai General Hospital, 1-17 Wakakusachou, Yao-shi, Osaka 581-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, National Hospital Organization, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kanaya","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, National Hospital Organization, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, National Hospital Organization, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-5630","authenticated-orcid":false,"given":"Alan Kawarai","family":"Lefor","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimostuke-shi 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-4324","authenticated-orcid":false,"given":"Hajime","family":"Katsukawa","sequence":"additional","affiliation":[{"name":"Japanese Society for Early Mobilization, 1-2-12 Kudankita, Tiyoda-ku, Tokyo 102-0073, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-0061","authenticated-orcid":false,"given":"Toru","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13054-021-03501-z","article-title":"Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: A prospective, multicenter, observational J-PICS study","volume":"25","author":"Kawakami","year":"2021","journal-title":"Crit. 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