{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:20:57Z","timestamp":1760232057186,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kyungpook National University Hospital Biomedical Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to evaluate the correlation between plasma lipocalin-2 (LCN2) levels and myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) seropositivity in patients with optic neuritis. Peripheral blood samples were collected from 19 patients with optic neuritis and 20 healthy controls. Plasma LCN2 and MOG-IgG levels were measured using enzyme-linked immunosorbent assay and a cell-based assay, respectively. The correlation between plasma LCN2 levels and MOG-IgG titers in patients with optic neuritis was analyzed. Receiver operating characteristic (ROC) curves were constructed to assess and compare the ability of plasma LCN2 and MOG-IgG levels for predicting optic neuritis recurrence. Patients with MOG-IgG\u2013positive optic neuritis had significantly higher mean plasma LCN2 levels than controls and patients with MOG-IgG\u2013negative optic neuritis (p = 0.037). Plasma LCN2 and MOG-IgG levels were significantly correlated in patients with optic neuritis (r = 0.553, p = 0.0141). There were no significant differences in the areas under the ROC curve (AUC) of plasma LCN2 (0.693, 95% confidence interval [CI] 0.443\u20130.880, p = 0.133) and MOG-IgG (0.641, 95% CI, 0.400\u20130.840, p = 0.298) levels (95% CI, \u22120.266\u20130.448, p = 0.618). Plasma LCN2 levels may aid differentiation of MOG-IgG\u2013positive optic neuritis from MOG-IgG\u2013negative optic neuritis.<\/jats:p>","DOI":"10.3390\/jcm11092635","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T08:04:21Z","timestamp":1651997061000},"page":"2635","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Plasma Lipocalin-2 Levels in Patients with Myelin Oligodendrocyte Glycoprotein-IgG\u2013Positive Optic Neuritis"],"prefix":"10.3390","volume":"11","author":[{"given":"Jong-Heon","family":"Kim","sequence":"first","affiliation":[{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-4203","authenticated-orcid":false,"given":"Kyoungho","family":"Suk","sequence":"additional","affiliation":[{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea"},{"name":"Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Young","family":"Chun","sequence":"additional","affiliation":[{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea"},{"name":"Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/WCO.0000000000000446","article-title":"Myelin oligodendrocyte glycoprotein autoantibodies: How clinically useful are they?","volume":"30","author":"Reindl","year":"2017","journal-title":"Curr. 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