{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:27:15Z","timestamp":1777116435977,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The increased use of vitrified blastocysts has encouraged the development of various criteria for selecting the embryo most likely to implant. Post-thaw assessment methods and timetables vary among investigators. We investigated the predictive value of well-defined measurements of human blastocyst re-expansion, following a fixed incubation period. Post-thaw measurements were taken exactly at 0 and 120 \u00b1 15 min. Minimum and maximum cross-sectional axes were measured. Three groups were defined: Group 1: embryos that continued to shrink by 10 \u00b5m or more; group 2: embryos that ranged from \u22129 to +9 \u00b5m; and group 3: re-expansion of 10 \u00b5m or more. Patient and morphokinetic data were collected and integrated into the analysis. A total of 115 cases were included. The clinical pregnancy rate for group 1 was 18.9%; group 2, 27%; and group 3, 51.2% (p = 0.007). Pre-thaw morphologic grading and morphokinetic scores of the study groups did not reveal differences. p-values were 0.17 for the pre-thaw morphologic score, 0.54 for KID3, and 0.37 for KID5. The patients\u2019 demographic and clinical data were similar. The clinical pregnancy rate correlated with the degree of thawed blastocyst re-expansion measured 2 h after incubation. This standardized measure is suggested as a tool to predict the potential of treatment success before embryo transfer.<\/jats:p>","DOI":"10.3390\/jcm11092673","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:30:28Z","timestamp":1652142628000},"page":"2673","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Standardization of Post-Vitrification Human Blastocyst Expansion as a Tool for Implantation Prediction"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-5470","authenticated-orcid":false,"given":"Anat","family":"Hershko-Klement","sequence":"first","affiliation":[{"name":"The IVF Unit, Department of Obstetrics and Gynecology, Hadassah Mt Scopus, The Hebrew University of Jerusalem, Jerusalem 91240, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaul","family":"Raviv","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luba","family":"Nemerovsky","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Rom","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayelet","family":"Itskovich","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danit","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Shulman","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehudith","family":"Ghetler","sequence":"additional","affiliation":[{"name":"The IVF Unit, Meir Medical Center, Department of Obstetrics and Gynecology, Affiliated to Sackler School of Medicine, Tel Aviv University, Kfar Saba 44281, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.fertnstert.2009.02.070","article-title":"Optimizing embryo selection with day 5 transfer","volume":"93","author":"Reh","year":"2010","journal-title":"Fertil. 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