{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:23Z","timestamp":1787028623627,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Appel d\u2019offre interne CHU Nantes public funding of the Nantes Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Deep brain stimulation (DBS) is an effective technique to treat patients with advanced Parkinson\u2019s disease. The surgical procedure of DBS implantation is generally performed under local anesthesia due to the need for intraoperative clinical testing. However, this procedure is long (5\u20137 h on average) and, therefore, the objective that the patient remains co-operative and tolerates the intervention well is a real challenge. Objective: To evaluate the additional benefit of electroacupuncture (EA) performed intraoperatively to improve the comfort of parkinsonian patients during surgical DBS implantation. Methods: This single-center randomized study compared two groups of patients. In the first group, DBS implantation was performed under local anesthesia alone, while the second group received EA in addition. The patients were evaluated preoperatively, during the different stages of the surgery, and 2 days after surgery, using the 9-item Edmonton Symptom Assessment System (ESAS), including a total sum score and physical and emotional subscores. Results: The data of nine patients were analyzed in each group. Although pain and tiredness increased in both groups after placement of the stereotactic frame, the ESAS item \u201clack of appetite\u201d, as well as the ESAS total score and physical subscore increased after completion of the first burr hole until the end of the surgical procedure in the control group only. ESAS total score and physical subscore were significantly higher at the end of the intervention in the control group compared to the EA group. After the surgical intervention (D2), anxiety and ESAS emotional subscore were improved in both groups, but the feeling of wellbeing improved in the EA group only. Finally, one patient developed delirium during the intervention and none in the EA group. Discussion: This study shows that intraoperative electroacupuncture significantly improves the tolerance of DBS surgery in parkinsonian patients. This easy-to-perform procedure could be fruitfully added in clinical practice.<\/jats:p>","DOI":"10.3390\/jcm11102680","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:31:55Z","timestamp":1652171515000},"page":"2680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Additional Benefit of Intraoperative Electroacupuncture in Improving Tolerance of Deep Brain Stimulation Surgical Procedure in Parkinsonian Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Sylvie","family":"Raoul","sequence":"first","affiliation":[{"name":"Service de Neurochirurgie, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Brissot","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pascal","family":"Lefaucheur","sequence":"additional","affiliation":[{"name":"EA4391, Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique, Universit\u00e9 Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Unit\u00e9 de Neurophysiologie Clinique, H\u00f4pital Henri Mondor, AP-HP, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service de Biostatistiques et d\u2019\u00e9pid\u00e9miologie, H\u00f4pital Saint Jacques, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Rouaud","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsan","family":"Meas","sequence":"additional","affiliation":[{"name":"Service Douleur, Soins palliatifs et de Support et UIC22, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Huchet","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndrianaina","family":"Razafimahefa","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Damier","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Nizard","sequence":"additional","affiliation":[{"name":"EA4391, Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique, Universit\u00e9 Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Service Douleur, Soins palliatifs et de Support et UIC22, H\u00f4pital Laennec, CHU, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service Douleur, Soins palliatifs et de Support et UIC22, H\u00f4pital Laennec, CHU, 44093 Nantes, France"},{"name":"Centre D\u2019\u00e9valuation et de Traitement de la Douleur, Clinique Br\u00e9t\u00e9ch\u00e9, Groupe Elsan, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000100803","article-title":"Combined (Thalamotomy and Stimulation) Stereotactic Surgery of the VIM Thalamic Nucleus for Bilateral Parkinson Disease","volume":"50","author":"Benabid","year":"1987","journal-title":"Ster. 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