{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:36:17Z","timestamp":1782815777838,"version":"3.54.5"},"reference-count":67,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Surgery, radiotherapy, and oncological treatment (chemotherapy and antineoplastic antibodies) are standard treatments of rectal cancer. ECT has shown its effectiveness and suitability in deep solid tumors conducted in both preclinical and clinical studies. We show here an update and preliminary results with locally advanced rectum cancer (LARC) treated with ECT. Methods: Two patients with major clinical response to restaging after neoadjuvant treatment for LARC were subjected to ECT 12 weeks after completing chemo-radiation therapy. One patient was subjected to ECT on a colorectal local recurrence formed after neoadjuvant treatment for LARC and surgery. Computed Tomography and Magnetic Resonance Imaging were used to assess ECT response. Results: The results showed stable disease in two of the three patients treated, while one patient achieved a complete response. The local control of disease is maintained in the patient follow-up. For each patient, a reduction in pain was observed and for the patient with local recurrence, a reduction in bleeding present before ECT was also achieved. Conclusion: Preliminary results showed that ECT is a safe and effective treatment in patients with a major clinical response or local recurrence after neoadjuvant therapy for LARC and allows a reduction in pain and bleeding with a consequent improvement to quality of life.<\/jats:p>","DOI":"10.3390\/jcm11102745","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"2745","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Electrochemotherapy of Primary Colon Rectum Cancer and Local Recurrence: Case Report and Prospective Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Daniela","family":"Rega","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery, Istituto Nazionale Tumori IRCCS Fondazione Pascale\u2014IRCCS di Napoli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-3221","authenticated-orcid":false,"given":"Vincenza","family":"Granata","sequence":"additional","affiliation":[{"name":"Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale\u2014IRCCS di Napoli, 80131 Naples, Italy"},{"name":"Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Via della Signora 2, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-5370","authenticated-orcid":false,"given":"Antonella","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale\u2014IRCCS di Napoli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Pace","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Istituto Nazionale 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Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3322\/caac.21220","article-title":"Colorectal cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dimi\u0107, D.S., Kalu\u0111erovi\u0107, G.N., Avdovi\u0107, E.H., Milenkovi\u0107, D.A., \u017divanovi\u0107, M.N., Poto\u010d\u0148\u00e1k, I., Samo\u013eov\u00e1, E., Dimitrijevi\u0107, M.S., Saso, L., and Markovi\u0107, Z.S. (2022). Synthesis, Crystallographic, Quantum Chemical, Antitumor, and Molecular Docking\/Dynamic Studies of 4-Hydroxycoumarin-Neurotransmitter Derivatives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23021001"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1463-1318.2006.01018.x","article-title":"Surgery for local recurrence of rectal cancer","volume":"8","author":"Heriot","year":"2006","journal-title":"Color. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11547-020-01297-6","article-title":"Dosimetric analysis of the effects of a temporary tissue expander on the radiotherapy technique","volume":"126","author":"Park","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s11547-020-01215-w","article-title":"MRI T2-weighted sequences-based texture analysis (TA) as a predictor of response to neoadjuvant chemo-radiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC)","volume":"125","author":"Capelli","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s11547-020-01189-9","article-title":"A comparative analysis between radiation dose intensification and conventional fractionation in neoadjuvant locally advanced rectal cancer: A monocentric prospective observational study","volume":"125","author":"Bertocchi","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1007\/s11547-020-01280-1","article-title":"The sub-millisievert era in CTCA: The technical basis of the new radiation dose approach","volume":"125","author":"Schicchi","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wieser, M., Sauerland, S., Arnold, D., Schmiegel, W., and Reinacher-Schick, A. (2010). Peri-operative chemotherapy for the treatment of resectable liver metastases from colorectal cancer: A systematic review and meta-analysis of randomized trials. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-309"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.3748\/wjg.v20.i20.6113","article-title":"Role of surgery in colorectal cancer liver metastases","volume":"20","author":"Tez","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s11547-021-01351-x","article-title":"Interventional Radiology ex-machina: Impact of Artificial Intelligence on practice","volume":"126","author":"Gurgitano","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s11547-020-01185-z","article-title":"Hepatic hemangiomas: The various imaging avatars and its mimickers","volume":"125","author":"Mathew","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11547-019-01092-y","article-title":"Characterization of liver nodules in patients with chronic liver disease by MRI: Performance of the Liver Imaging Reporting and Data System (LI-RADS v.2018) scale and its comparison with the Likert scale","volume":"125","author":"Esposito","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11547-020-01240-9","article-title":"Factors affecting the response to Y-90 microsphere therapy in the cholangiocarcinoma patients","volume":"126","author":"Bozkurt","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s11547-020-01221-y","article-title":"Sclerotic changes of cavernous hemangioma in the cirrhotic liver: Long-term follow-up using dynamic contrast-enhanced com- puted tomography","volume":"125","author":"Shin","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s11547-020-01175-1","article-title":"Radiofrequency ablation (RFA) of T1a renal cancer with externally cooled multitined expandable electrodes","volume":"125","author":"Ziglioli","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s11547-020-01294-9","article-title":"Renal artery embolization of non-functioning graft: An effective treatment for graft intolerance syndrome","volume":"126","author":"Fantoni","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1016\/0006-2952(88)90344-9","article-title":"Transient electropermeabilization of cells in culture: Increase of the cytotoxicity of anticancer drugs","volume":"37","author":"Orlowski","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"ref_19","first-page":"3450","article-title":"Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice","volume":"55","author":"Sersa","year":"1995","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1002\/1097-0142(19931215)72:12<3694::AID-CNCR2820721222>3.0.CO;2-2","article-title":"Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial","volume":"72","author":"Belehradek","year":"1993","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejcsup.2006.08.005","article-title":"Bases and rationale of the electrochemotherapy","volume":"4","author":"Mir","year":"2006","journal-title":"Eur. J. Cancer Suppl."},{"key":"ref_22","first-page":"613","article-title":"L\u2019\u00e9lectrochimioth\u00e9rapie, un nouveau traitement antitumoral: Premier essai clinique","volume":"313","author":"Mir","year":"1991","journal-title":"Comptes Rendus Acad. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejcsup.2006.08.002","article-title":"Electrochemotherapy\u2014An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study","volume":"4","author":"Marty","year":"2006","journal-title":"Eur. J. Cancer Suppl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejcsup.2006.08.003","article-title":"Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes","volume":"4","author":"Mir","year":"2006","journal-title":"Eur. J. Cancer Suppl."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/0284186X.2018.1454602","article-title":"Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases","volume":"57","author":"Gehl","year":"2018","journal-title":"Acta Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1245\/s10434-008-0204-8","article-title":"Bleomycin-Based Electrochemotherapy: Clinical Outcome from a Single Institution\u2019s Experience with 52 Patients","volume":"16","author":"Campana","year":"2009","journal-title":"Ann. Surg. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/bjs.8749","article-title":"Electrochemotherapy for disseminated superficial metastases from malignant melanoma","volume":"99","author":"Campana","year":"2012","journal-title":"Br. J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejso.2012.08.016","article-title":"Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis","volume":"39","author":"Mali","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejca.2016.05.001","article-title":"European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer","volume":"63","author":"Bertino","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejca.2017.10.008","article-title":"European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers","volume":"87","author":"Plaschke","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1515\/raon-2016-0003","article-title":"Electrochemotherapy in pancreatic adenocarcinoma treatment: Pre-clinical and clinical studies","volume":"50","author":"Bimonte","year":"2016","journal-title":"Radiol. Oncol."},{"key":"ref_32","first-page":"S100","article-title":"246. Electrochemotherapy for rectal cancer after neoadjuvant radiotherapy: A case report","volume":"40","author":"Rega","year":"2014","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3748\/wjg.v23.i5.906","article-title":"Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study","volume":"23","author":"Tarantino","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1475-925X-14-S3-S5","article-title":"Electrochemotherapy of colorectal liver metastases\u2014An observational study of its effects on the electrocardiogram","volume":"14","author":"Mali","year":"2015","journal-title":"Biomed. Eng. Online"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jso.23625","article-title":"Intraoperative electrochemotherapy of colorectal liver metastases","volume":"110","author":"Edhemovic","year":"2014","journal-title":"J. Surg. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/raon-2015-0013","article-title":"Feasibility and safety of electrochemotherapy (ECT) in the pancreas: A pre-clinical investigation","volume":"49","author":"Girelli","year":"2015","journal-title":"Radiol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.3748\/wjg.v23.i26.4767","article-title":"Early radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy","volume":"23","author":"Granata","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ejso.2018.01.090","article-title":"Electrochemotherapy as treatment option for hepatocellular carcinoma, a prospective pilot study","volume":"44","author":"Djokic","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.diii.2019.01.001","article-title":"Multimodal image-guided electrochemotherapy of unresectable liver metastasis from renal cell cancer","volume":"100","author":"Cornelis","year":"2019","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1533033818809994","DOI":"10.1177\/1533033818809994","article-title":"Electroporation of the Liver: More Than 2 Concurrently Active, Curved Electrodes Allow New Concepts for Irreversible Electroporation and Electrochemotherapy","volume":"17","author":"Ritter","year":"2018","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ejso.2018.06.025","article-title":"Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: A feasibility study","volume":"44","author":"Tarantino","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"ICRU (2010). International Commission on Radiation Units and Measurements: Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT). ICRU Report 83. J. ICRU, 10, 41\u201353.","DOI":"10.1093\/jicru\/ndq002"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rega, D., Granata, V., Petrillo, A., Pace, U., Sassaroli, C., Di Marzo, M., Cervone, C., Fusco, R., D\u2019Alessio, V., and Nasti, G. (2021). Organ Sparing for Locally Advanced Rectal Cancer after Neoadjuvant Treatment Followed by Electrochemotherapy. Cancers, 13.","DOI":"10.3390\/cancers13133199"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rega, D., Granata, V., Romano, C., D\u2019Angelo, V., Pace, U., Fusco, R., Cervone, C., Ravo, V., Tatangelo, F., and Avallone, A. (2021). Watch and Wait Approach for Rectal Cancer Following Neoadjuvant Treatment: The Experience of a High Volume Cancer Center. Diagnostics, 11.","DOI":"10.3390\/diagnostics11081507"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s13304-016-0362-3","article-title":"TAMIS for rectal tumors: Advancements of a new approach","volume":"68","author":"Rega","year":"2016","journal-title":"Updat. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rega, D., Pecori, B., Scala, D., Avallone, A., Pace, U., Petrillo, A., Aloj, L., Tatangelo, F., and Delrio, P. (2016). Evaluation of Tumor Response after Short-Course Radiotherapy and Delayed Surgery for Rectal Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160732"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1007\/s11547-021-01369-1","article-title":"Validation of the standardized index of shape tool to analyze DCE-MRI data in the assessment of neo-adjuvant therapy in locally advanced rectal cancer","volume":"126","author":"Fusco","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1007\/s11547-021-01389-x","article-title":"A deep look into radiomics","volume":"126","author":"Scapicchio","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11547-021-01333-z","article-title":"CT-derived radiomic features to discriminate histologic characteristics of pancreatic neuroendocrine tumors","volume":"126","author":"Benedetti","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s11547-021-01406-z","article-title":"CT-guided percutaneous drainage of abdominopelvic collections: A pictorial essay","volume":"126","author":"Puglisi","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11547-020-01266-z","article-title":"A field strength independent MR radiomics model to predict pathological complete response in locally advanced rectal cancer","volume":"126","author":"Cusumano","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s11547-020-01137-7","article-title":"Primary and post-chemoradiotherapy MRI detection of extramural venous invasion in rectal cancer: The role of diffusion-weighted imaging","volume":"125","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s11547-021-01392-2","article-title":"Whole-body magnetic resonance imaging (WB-MRI) for cancer screening: Recommendations for use","volume":"126","author":"Petralia","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1007\/s11547-020-01220-z","article-title":"Dynamic contrast-enhanced MRI in oncology: How we do it","volume":"125","author":"Petralia","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1200\/JCO.2014.60.1054","article-title":"Advances and Challenges in Treatment of Locally Advanced Rectal Cancer","volume":"33","author":"Smith","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/SLA.0000000000000368","article-title":"Increasing the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer: A meta-analysis of published studies","volume":"263","author":"Petrelli","year":"2016","journal-title":"Ann. Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/sj.bjc.6603195","article-title":"Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: A phase I-II study","volume":"94","author":"Avallone","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30394","DOI":"10.18632\/oncotarget.4724","article-title":"Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: Results of the branch trial","volume":"6","author":"Avallone","year":"2015","journal-title":"Oncotarget"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.ijrobp.2009.12.007","article-title":"Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome","volume":"79","author":"Avallone","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Avallone, A., Piccirillo, M.C., Delrio, P., Pecori, B., Di Gennaro, E., Aloj, L., Tatangelo, F., D\u2019Angelo, V., Granata, C., and Cavalcanti, E. (2014). Phase 1\/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid\u2013short Radiotherapy\u2013rectum 3rd trial). BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-875"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"E727","DOI":"10.1055\/a-0590-4053","article-title":"Endoscopic electrochemotherapy for esophageal cancer: A phase I clinical study","volume":"6","author":"Egeland","year":"2018","journal-title":"Endosc. Int. Open"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Engstrand, J., Nilsson, H., Str\u00f6mberg, C., Jonas, E., and Freedman, J. (2018). Colorectal cancer liver metastases\u2014A population-based study on incidence, management and survival. BMC Cancer, 18.","DOI":"10.1186\/s12885-017-3925-x"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Hackl, C., Neumann, P., Gerken, M., Loss, M., Klinkhammer-Schalke, M., and Schlitt, H.J. (2014). Treatment of colorectal liver metastases in Germany: A ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-810"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"475","DOI":"10.7785\/tcrt.2012.500224","article-title":"Electrochemotherapy: A New Technological Approach in Treatment of Metastases in the Liver","volume":"10","author":"Edhemovic","year":"2011","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/1533034615604454","article-title":"Feasibility of Electroporation in Bone and in the Surrounding Clinically Relevant Structures: A Preclinical Investigation","volume":"15","author":"Tschon","year":"2016","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijsu.2017.06.033","article-title":"Safety and feasibility of electrochemotherapy in patients with unresectable colorectal liver metastases: A pilot study","volume":"44","author":"Coletti","year":"2017","journal-title":"Int. J. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ejso.2020.04.037","article-title":"Intraoperative electrochemotherapy of colorectal liver metastases: A prospective phase II study","volume":"46","author":"Edhemovic","year":"2020","journal-title":"Eur. J. Surg. Oncol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/10\/2745\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:09:58Z","timestamp":1760137798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/10\/2745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":67,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["jcm11102745"],"URL":"https:\/\/doi.org\/10.3390\/jcm11102745","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]}}}