{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:03:46Z","timestamp":1782299026635,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Valenciana de Patolog\u00eda Digestiva"},{"name":"Vifor Pharma Espa\u00f1a S.L., Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Iron deficiency (ID) without anaemia is a common comorbidity associated with inflammatory bowel disease (IBD) that has a negative impact on health-related quality of life (HRQoL). Methods: This multicentre, prospective, observational study examined the response to, safety of and impact on HRQoL of a single 500 mg dose of intravenous ferric carboxymaltose (FCM) in patients with IBD and ID without anaemia. The diagnostic criteria for ID were low serum ferritin (&lt;30 \u00b5g\/L in the absence of inflammatory activity or &lt;100 \u00b5g\/L with inflammation) and transferrin saturation index (TSAT) &lt; 16%. The effect on iron levels and HRQoL, according to the health status questionnaires SF-12v2 and EQ-5D, was evaluated 1 month after FCM infusion in an outpatient setting. Results: Of the 105 patients who received FCM, 98 patients completed the study. After 1 month, a single dose of FCM significantly increased serum ferritin, serum iron and TSAT. Importantly, patients reported fewer ID symptoms and problems on all EQ-5D dimensions. They also had higher EQ-5D visual analogue scale and SF-12v2 scores after treatment. FCM had similar clinical effects on men and women and on patients with Crohn\u2019s disease (n = 66) and ulcerative colitis (n = 32). Conclusion: A single dose of FCM rapidly restored iron parameters and significantly improved patients\u2019 symptoms and HRQoL at 1 month after treatment.<\/jats:p>","DOI":"10.3390\/jcm11102786","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T09:48:22Z","timestamp":1652608102000},"page":"2786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ferric Carboxymaltose Improves the Quality of Life of Patients with Inflammatory Bowel Disease and Iron Deficiency without Anaemia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-1262","authenticated-orcid":false,"given":"Jose Mar\u00eda","family":"Huguet","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-8211","authenticated-orcid":false,"given":"Xavier","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Sagunto, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-8797","authenticated-orcid":false,"given":"Marta Maia","family":"Bosc\u00e1-Watts","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednico Universitario de Valencia, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital General Universitario de Castell\u00f3n, 12004 Castesllon de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Maroto","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Manises, 46940 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Iborra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario y Polit\u00e9cnico de La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hinojosa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Manises, 46940 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Capilla","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Asencio","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cirilo","family":"Amoros","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Arnau de Vilanova de Valencia, 46015 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mar\u00eda","family":"Paredes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"ref_1","first-page":"S516","article-title":"Epidemiology, clinical characteristics, evolution and treatments in newly diagnosed inflammatory bowel disease (IBD): Results from the nationwide EpidemIBD study of GETECCU","volume":"14","author":"Chaparro","year":"2020","journal-title":"J. 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