{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:55:54Z","timestamp":1762052154616,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science and Innovation","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]},{"name":"Xunta de Galicia","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]},{"name":"Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]},{"name":"T. Sobrino","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]},{"name":"F. Campos","award":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"],"award-info":[{"award-number":["SAF2017-84267-R","PDC2021-121455-I00","IN607A2018\/3","PI17\/00540","PI17\/01103","ISCIII\/PI21\/01256","RD16\/0019\/0001","D21\/0006\/0003","CPII17\/00027","CPII19\/00020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Malignant infarction of the middle cerebral artery (m-MCA) is a complication of ischemic stroke. Since hyperthermia is a predictor of poor outcome, and antihyperthermic treatment is well tolerated, our main aim was to analyze whether the systemic temperature decrease within the first 24 h was associated with a better outcome. Furthermore, we studied potential biochemical and neuroimaging biomarkers. This is a retrospective observational analysis that included 119 patients. The temperature variations within the first 24 h were recorded. Biochemical laboratory parameters and neuroimaging variables were also analyzed. The temperature increase at the first 24 h (OR: 158.97; CI 95%: 7.29\u20133465.61; p &lt; 0.001) was independently associated with a higher mortality. Moreover, antihyperthermic treatment (OR: 0.08; CI 95%: 0.02\u20130.38; p = 0.002) was significantly associated with a good outcome at 3 months. Importantly, antihyperthermic treatment was associated with higher survival at 3 months (78% vs. 50%, p = 0.003). Significant independently associations between the development of m-MCA and both microalbuminuria (OR: 1.01; CI 95%: 1.00\u20131.02; p = 0.005) and leukoaraiosis (OR: 3.07; CI 1.84\u20135.13\u20131.02; p &lt; 0.0001) were observed. Thus, antihyperthermic treatment within the first 24 h was associated with both a better outcome and higher survival. An increased risk of developing m-MCA was associated with leukoaraiosis and an elevated level of microalbuminuria.<\/jats:p>","DOI":"10.3390\/jcm11102874","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T12:25:57Z","timestamp":1652963157000},"page":"2874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-5271","authenticated-orcid":false,"given":"Maria Luz","family":"Alonso-Alonso","sequence":"first","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-3893","authenticated-orcid":false,"given":"Ana","family":"Sampedro-Viana","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Rodr\u00edguez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iria","family":"L\u00f3pez-Dequidt","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3992","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Pumar","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Department of Neuroradiology, Health Research Institute of Santiago de Compostela (IDIS), Hospital Cl\u00ednico Universitario, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J.","family":"Mosqueira","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Department of Neuroradiology, Health Research Institute of Santiago de Compostela (IDIS), Hospital Cl\u00ednico Universitario, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-1704","authenticated-orcid":false,"given":"Alberto","family":"Ouro","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"\u00c1vila-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-8690","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Sobrino","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-1039","authenticated-orcid":false,"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[{"name":"Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archneur.1996.00550040037012","article-title":"\u201cMalignant\u201d Middle Cerebral Artery Territory Infarction: Clinical Course and Prognostic Signs","volume":"53","author":"Hacke","year":"1996","journal-title":"Arch. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.nrl.2013.02.009","article-title":"Malignant Hemispheric Infarction of the Middle Cerebral Artery. Diagnostic Considerations and Treatment Options","volume":"31","author":"Godoy","year":"2016","journal-title":"Neurologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000441627","article-title":"Malignant MCA Infarction: Pathophysiology and Imaging for Early Diagnosis and Management Decisions","volume":"41","author":"Heiss","year":"2016","journal-title":"Cerebrovasc. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"BSR20191448","DOI":"10.1042\/BSR20191448","article-title":"Decompressive Hemicraniectomy versus Medical Treatment of Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis","volume":"40","author":"Wei","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.wneu.2018.11.176","article-title":"Decompressive Hemicraniectomy in the Treatment of Malignant Middle Cerebral Artery Infarction: A Meta-Analysis","volume":"123","author":"Das","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000090007","article-title":"Safety and Therapeutical Benefit of Hemicraniectomy Combined with Mild Hypothermia in Comparison with Hemicraniectomy Alone in Patients with Malignant Ischemic Stroke","volume":"21","author":"Els","year":"2006","journal-title":"Cerebrovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/jamaneurol.2018.4822","article-title":"Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial","volume":"76","author":"Neugebauer","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105569","DOI":"10.1016\/j.clineuro.2019.105569","article-title":"Outcomes of Therapeutic Hypothermia in Patients Treated with Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis","volume":"188","author":"Chen","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/s-0033-1364211","article-title":"Management of the Malignant Middle Cerebral Artery Syndrome","volume":"33","author":"Hwang","year":"2014","journal-title":"Semin. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.neuint.2012.02.003","article-title":"Influence of Temperature on Ischemic Brain: Basic and Clinical Principles","volume":"60","author":"Campos","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1474-4422(07)70036-4","article-title":"Early Decompressive Surgery in Malignant Infarction of the Middle Cerebral Artery: A Pooled Analysis of Three Randomised Controlled Trials","volume":"6","author":"Vahedi","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1590\/0004-282x20170053","article-title":"Decompressive Craniotomy for the Treatment of Malignant Infarction of the Middle Cerebral Artery: Mortality and Outcome","volume":"75","author":"Bongiorni","year":"2017","journal-title":"Arq. Neuro-Psiquiatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/02688697.2017.1329518","article-title":"Decompressive Craniectomy for the Treatment of Malignant Middle Cerebral Artery Infarction","volume":"31","author":"Crocker","year":"2017","journal-title":"Br. J. Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/01.STR.29.9.1888","article-title":"Early Hemicraniectomy in Patients with Complete Middle Cerebral Artery Infarction","volume":"29","author":"Schwab","year":"1998","journal-title":"Stroke"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MCC.0b013e32835075c5","article-title":"Malignant Middle Cerebral Artery Infarction","volume":"18","author":"Wartenberg","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0140-6736(91)93206-O","article-title":"Classification and Natural History of Clinically Identifiable Subtypes of Cerebral Infarction","volume":"337","author":"Bamford","year":"1991","journal-title":"Lancet"},{"key":"ref_17","first-page":"192","article-title":"NIH Stroke Scale and Its Adaptation to Spanish","volume":"21","author":"Montaner","year":"2006","journal-title":"Neurologia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver Agreement for the Assessment of Handicap in Stroke Patients","volume":"19","author":"Koudstaal","year":"1988","journal-title":"Stroke"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of Subtype of Acute Ischemic Stroke. Definitions for Use in a Multicenter Clinical Trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1212\/WNL.0b013e3181aa5329","article-title":"ABC\/2 for Rapid Clinical Estimate of Infarct, Perfusion, and Mismatch Volumes","volume":"72","author":"Sims","year":"2009","journal-title":"Neurology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR Signal Abnormalities at 1.5 T in Alzheimer\u2019s Dementia and Normal Aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.028","article-title":"Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging","volume":"27","author":"Ferguson","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_23","first-page":"102","article-title":"Guidelines for the Treatment of Acute Ischaemic Stroke","volume":"29","author":"Egido","year":"2014","journal-title":"Neurologia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"\u00c1vila-G\u00f3mez, P., Hervella, P., Da Silva-Candal, A., P\u00e9rez-Mato, M., Rodr\u00edguez-Y\u00e1\u00f1ez, M., L\u00f3pez-Dequidt, I., Pumar, J.M., Castillo, J., Sobrino, T., and Iglesias-Rey, R. (2020). Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers. J. Clin. Med., 9.","DOI":"10.3390\/jcm9072108"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116607","DOI":"10.1016\/j.jns.2019.116607","article-title":"Predictors of Malignant Cerebral Edema in Cerebral Artery Infarction: A Meta-Analysis","volume":"409","author":"Miao","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e1738","DOI":"10.1212\/WNL.0000000000009288","article-title":"Antihyperthermic Treatment Decreases Perihematomal Hypodensity","volume":"94","author":"Hervella","year":"2020","journal-title":"Neurology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"594672","DOI":"10.3389\/fneur.2020.594672","article-title":"Pathophysiology of Blood-Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery","volume":"11","author":"Sousa","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1161\/STROKEAHA.115.008861","article-title":"Assessment of Blood\u2013Brain Barrier Disruption in Stroke","volume":"46","author":"Kassner","year":"2015","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/01.STR.0000177870.14967.94","article-title":"The Prediction of Malignant Cerebral Infarction by Molecular Brain Barrier Disruption Markers","volume":"36","author":"Serena","year":"2005","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/01.wnl.0000238353.89194.08","article-title":"Micro- and Macroalbuminuria Predict Hemorrhagic Transformation in Acute Ischemic Stroke","volume":"67","author":"Castellanos","year":"2006","journal-title":"Neurology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"652867","DOI":"10.3389\/fneur.2021.652867","article-title":"STWEAK as Predictor of Stroke Recurrence in Ischemic Stroke Patients Treated With Reperfusion Therapies","volume":"12","author":"Hervella","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/acn3.51171","article-title":"The Presence of Leukoaraiosis Enhances the Association between STWEAK and Hemorrhagic Transformation","volume":"7","author":"Pumar","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/svn-2020-000684","article-title":"STWEAK Is a Marker of Early Haematoma Growth and Leukoaraiosis in Intracerebral Haemorrhage","volume":"6","author":"Pumar","year":"2021","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/acn3.51502","article-title":"sTWEAK Is a Leukoaraiosis Biomarker Associated with Neurovascular Angiopathy","volume":"9","author":"Custodia","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1001\/archneur.56.6.699","article-title":"Microalbuminuria in Ischemic Stroke","volume":"56","author":"Beamer","year":"1999","journal-title":"Arch. Neurol."},{"key":"ref_37","first-page":"OC29","article-title":"Early Clinical Implications of Microalbuminuria in Patients with Acute Ischaemic Stroke","volume":"10","author":"Thampy","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000317069","article-title":"Level of Albuminuria and Risk of Stroke: Systematic Review and Meta-Analysis","volume":"30","author":"Lee","year":"2010","journal-title":"Cerebrovasc. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1586\/14737175.3.2.215","article-title":"Microalbuminuria in Cerebrovascular Diseases","volume":"3","author":"Turaj","year":"2003","journal-title":"Expert Rev. Neurother."},{"key":"ref_40","first-page":"498","article-title":"Microalbuminuria in Patients with Acute Ischemic Stroke","volume":"41","author":"Li","year":"2019","journal-title":"Neurol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00115-012-3678-3","article-title":"Microalbuminuria","volume":"83","author":"Gumbinger","year":"2012","journal-title":"Nervenarzt"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1161\/STROKEAHA.110.581215","article-title":"Impact of Microalbuminuria on Incident Stroke","volume":"41","author":"Lee","year":"2010","journal-title":"Stroke"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2008.04.007","article-title":"Microalbuminuria: Risk Factor and Potential Therapeutic Target for Stroke?","volume":"271","author":"Ovbiagele","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e25751","DOI":"10.1097\/MD.0000000000025751","article-title":"The Association between White Matter Changes and Development of Malignant Middle Cerebral Artery Infarction","volume":"100","author":"Wu","year":"2021","journal-title":"Medicine"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/10\/2874\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:14:55Z","timestamp":1760138095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/10\/2874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["jcm11102874"],"URL":"https:\/\/doi.org\/10.3390\/jcm11102874","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,5,19]]}}}