{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:57:18Z","timestamp":1787500638747,"version":"build-2736575974"},"reference-count":178,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Annual Funding Track by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University","award":["AN00091"],"award-info":[{"award-number":["AN00091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Neuropathic pain affects more than one million people across the globe. The quality of life of people suffering from neuropathic pain has been considerably declining due to the unavailability of appropriate therapeutics. Currently, available treatment options can only treat patients symptomatically, but they are associated with severe adverse side effects and the development of tolerance over prolonged use. In the past decade, researchers were able to gain a better understanding of the mechanisms involved in neuropathic pain; thus, continuous efforts are evident, aiming to develop novel interventions with better efficacy instead of symptomatic treatment. The current review discusses the latest interventional strategies used in the treatment and management of neuropathic pain. This review also provides insights into the present scenario of pain research, particularly various interventional techniques such as spinal cord stimulation, steroid injection, neural blockade, transcranial\/epidural stimulation, deep brain stimulation, percutaneous electrical nerve stimulation, neuroablative procedures, opto\/chemogenetics, gene therapy, etc. In a nutshell, most of the above techniques are at preclinical stage and facing difficulty in translation to clinical studies due to the non-availability of appropriate methodologies. Therefore, continuing research on these interventional strategies may help in the development of promising novel therapies that can improve the quality of life of patients suffering from neuropathic pain.<\/jats:p>","DOI":"10.3390\/jcm11113002","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:05:07Z","timestamp":1653635107000},"page":"3002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-0803","authenticated-orcid":false,"given":"Pottathil","family":"Shinu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-9094","authenticated-orcid":false,"given":"Mohamed A.","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"},{"name":"Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-8669","authenticated-orcid":false,"given":"Anroop B.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-2057","authenticated-orcid":false,"given":"Abdulaziz K. Al","family":"Mouslem","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-1549","authenticated-orcid":false,"given":"Katharigatta N.","family":"Venugopala","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"},{"name":"Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail 35816, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail 35816, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-6673","authenticated-orcid":false,"given":"Shery","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-2874","authenticated-orcid":false,"given":"Pran Kishore","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s42466-020-00063-3","article-title":"Guideline \u201cdiagnosis and non interventional therapy of neuropathic pain\u201d of the German Society of Neurology (deutsche Gesellschaft f\u00fcr Neurologie)","volume":"2","author":"Schlereth","year":"2020","journal-title":"Neurol. Res. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2337\/dc11-1108","article-title":"Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K","volume":"34","author":"Abbott","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2147\/JPR.S298100","article-title":"Comparison of Predisposing Factors Between Pain on Walking and Pain at Rest in Patients with Knee Osteoarthritis","volume":"14","author":"Satake","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e010364","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: A systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2147\/JPR.S127014","article-title":"The prevalence of probable neuropathic pain in the US: Results from a multimodal general-population health survey","volume":"10","author":"DiBonaventura","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: From Mechanisms to Treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/j.pain.0000000000002107","article-title":"The Parkinson disease pain classification system: Results from an international mechanism-based classification approach","volume":"162","author":"Mylius","year":"2021","journal-title":"Pain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1097\/01.j.pain.0000460358.01998.15","article-title":"Pharmacotherapy of neuropathic pain: Which drugs, which treatment algorithms?","volume":"156","author":"Attal","year":"2015","journal-title":"Pain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1213\/ANE.0000000000001998","article-title":"Interventions for Neuropathic Pain: An Overview of Systematic Reviews","volume":"125","author":"Dosenovic","year":"2017","journal-title":"Anesth. Analg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.pain.2013.06.004","article-title":"Interventional management of neuropathic pain: NeuPSIG recommendations","volume":"154","author":"Dworkin","year":"2013","journal-title":"Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/pm\/pnaa109","article-title":"Analysis of SCN9A Gene Variants for Acute and Chronic Postoperative Pain and Morphine Consumption After Total Hysterectomy","volume":"21","author":"Yeo","year":"2020","journal-title":"Pain Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"12743","DOI":"10.1038\/s41598-017-12972-6","article-title":"Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liao, M.-F., Yeh, S.-R., Lu, K.-T., Hsu, J.-L., Chao, P.-K., Hsu, H.-C., Peng, C.-H., Lee, Y.-L., Hung, Y.-H., and Ro, L.-S. (2021). Interactions between Autophagy, Proinflammatory Cytokines, and Apoptosis in Neuropathic Pain: Granulocyte Colony Stimulating Factor as a Multipotent Therapy in Rats with Chronic Constriction Injury. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050542"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncpneuro0113","article-title":"Mechanisms of disease: Neuropathic pain--a clinical perspective","volume":"2","author":"Baron","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/5584_2018_326","article-title":"Lidocaine, a Non-selective Inhibitor of Voltage-Gated Sodium Channels, Blocks Chemically-Induced Cough in Awake Na\u00efve Guinea Pigs","volume":"1160","author":"Svajdova","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2019.01.047","article-title":"Defining the Functional Role of Na(V)1.7 in Human Nociception","volume":"101","author":"McDermott","year":"2019","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.neuron.2021.03.012","article-title":"A central mechanism of analgesia in mice and humans lacking the sodium channel Na(V)1.7","volume":"109","author":"MacDonald","year":"2021","journal-title":"Neuron"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1744-8069-8-82","article-title":"Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn","volume":"8","author":"Black","year":"2012","journal-title":"Mol. Pain"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, X.D., Yang, J.J., Fang, D., Cai, J., Wan, Y., and Xing, G.G. (2014). Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0114623"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.pain.2014.06.015","article-title":"Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli","volume":"155","author":"Hockley","year":"2014","journal-title":"Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2519\/jospt.2020.0610","article-title":"Central Sensitization in Musculoskeletal Pain: Lost in Translation?","volume":"50","author":"Schmid","year":"2020","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: Do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Santana, L. (2014). Pathophysiology of pain. Essentials of Pediatric Anesthesiology, Cambridge University Press.","DOI":"10.1017\/CBO9781107375338.018"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/pr.117.014399","article-title":"Etiology and Pharmacology of Neuropathic Pain","volume":"70","author":"Alles","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.spinee.2012.10.036","article-title":"Different symptoms of neuropathic pain can be induced by different degrees of compressive force on the C7 dorsal root of rats","volume":"12","author":"Huang","year":"2012","journal-title":"Spine J."},{"key":"ref_29","first-page":"1990","article-title":"Understanding peripheral neuropathic pain in primary care: Diagnosis and management","volume":"25","author":"Bussa","year":"2021","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/1061186X.2019.1587444","article-title":"Emerging role of nanomedicine in the treatment of neuropathic pain","volume":"28","author":"Bidve","year":"2020","journal-title":"J. Drug Target."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bernetti, A., Agostini, F., de Sire, A., Mangone, M., Tognolo, L., Di Cesare, A., Ruiu, P., Paolucci, T., Invernizzi, M., and Paoloni, M. (2021). Neuropathic pain and rehabilitation: A systematic review of international guidelines. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010074"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.amjmed.2009.04.006","article-title":"Assessment of neuropathic pain in primary care","volume":"122","author":"Backonja","year":"2009","journal-title":"Am. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Migliore, A., Gigliucci, G., Moretti, A., Pietrella, A., Peresson, M., Atzeni, F., Sarzi-Puttini, P., Bazzichi, L., Liguori, S., and Iolascon, G. (2021). Cross Cultural Adaptation and Validation of Italian Version of the Leeds Assessment of Neuropathic Symptoms and Signs Scale and Pain DETECT Questionnaire for the Distinction between Nociceptive and Neuropathic Pain. Pain Res. Manag., 2021.","DOI":"10.1155\/2021\/6623651"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/pm\/pnaa407","article-title":"AAAPT Diagnostic Criteria for Acute Neuropathic Pain","volume":"22","author":"Doshi","year":"2021","journal-title":"Pain Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3340\/jkns.2013.53.2.132","article-title":"Usefulness of ultrasound for detecting suspected peripheral nerve lesions in diagnosis of peripheral neuropathy: Case report and brief review of the literature","volume":"53","author":"Jung","year":"2013","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.pain.2007.03.030","article-title":"Usefulness and limitations of quantitative sensory testing: Clinical and research application in neuropathic pain states","volume":"129","author":"Hansson","year":"2007","journal-title":"Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jmri.26183","article-title":"Applications of PET-MRI in musculoskeletal disease","volume":"48","author":"Kogan","year":"2018","journal-title":"J. Magn. Reson. Imaging JMRI"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s10072-021-05434-5","article-title":"Skin biopsy and quantitative sensory assessment in an Italian cohort of ATTRv patients with polyneuropathy and asymptomatic carriers: Possible evidence of early non-length dependent denervation","volume":"43","author":"Leonardi","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1468-1331.2004.00791.x","article-title":"EFNS guidelines on neuropathic pain assessment","volume":"11","author":"Cruccu","year":"2004","journal-title":"Eur. J. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.disamonth.2013.12.001","article-title":"Neuropathic pain: Etiology, pathophysiology, mechanisms, and evaluations","volume":"60","author":"Jay","year":"2014","journal-title":"Dis.-A-Mon."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neurol.2018.08.005","article-title":"Pharmacological treatments of neuropathic pain: The latest recommendations","volume":"175","author":"Attal","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_42","first-page":"91","article-title":"Systemic drug therapy for neuropathic pain","volume":"17","author":"Sredni","year":"2016","journal-title":"Rev. Dor"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/j.pain.0000000000000189","article-title":"Tricyclic antidepressants and opioids\u2014better together?","volume":"156","author":"Rowbotham","year":"2015","journal-title":"Pain"},{"key":"ref_44","first-page":"121","article-title":"Discontinuation Syndrome of Extended-Release Venlafaxine during the COVID-19 Epidemic","volume":"33","author":"Gong","year":"2021","journal-title":"Psychiatr. Danub."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1176\/ajp.154.12.1760","article-title":"Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine","volume":"154","author":"Fava","year":"1997","journal-title":"Am. J. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.46542\/pe.2021.212.225229","article-title":"IAI CONFERENCE: Comparing the quality of life of neuropathic patients treated with gabapentin and pregabalin at the neuropathic poly of the NTB provincial hospital in 2019","volume":"21","author":"Qiyaam","year":"2021","journal-title":"Pharm. Educ."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ghayur, M.N. (2021). Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin. Case Rep. Med., 2021.","DOI":"10.1155\/2021\/5559981"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_49","first-page":"012","article-title":"The analgesic effect of tramadol versus morphine in the treatment of cancer pain in National Cancer Institute, University of Gezira, Sudan (2018)","volume":"5","author":"Ibrahim","year":"2021","journal-title":"Open J. Pain Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Rafiullah, M., and Siddiqui, K. (2021). Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update. CNS Neurol. Disord. Drug Targets, 21.","DOI":"10.2174\/1871527320666210303111939"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.06.019","article-title":"The evidence for pharmacological treatment of neuropathic pain","volume":"150","author":"Finnerup","year":"2010","journal-title":"Pain"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.1097\/PR9.0000000000000611","article-title":"Acute pain management in patients with drug dependence syndrome","volume":"2","author":"Quinlan","year":"2017","journal-title":"Pain Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1474-4422(16)00017-X","article-title":"Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): A randomised, double-blind, placebo-controlled trial","volume":"15","author":"Attal","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ferraz, C.R., Carvalho, T.T., Manchope, M.F., Artero, N.A., Rasquel-Oliveira, F.S., Fattori, V., Casagrande, R., and Verri, W.A. (2020). Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development. Molecules, 25.","DOI":"10.3390\/molecules25030762"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00000542-200404000-00025","article-title":"Analgesic effects of gabapentin after spinal surgery","volume":"100","author":"Turan","year":"2004","journal-title":"J. Am. Soc. Anesthesiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1468-1331.2007.01916.x","article-title":"EFNS guidelines on neurostimulation therapy for neuropathic pain","volume":"14","author":"Cruccu","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s42234-019-0023-1","article-title":"Spinal cord stimulation in chronic pain: Evidence and theory for mechanisms of action","volume":"5","author":"Caylor","year":"2019","journal-title":"Bioelectron. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00132586-196704000-00002","article-title":"Pain mechanisms: A new theory","volume":"11","author":"Melzack","year":"1967","journal-title":"Surv. Anesthesiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0072-9752(06)80064-3","article-title":"Spinal cord stimulation for neuropathic pain","volume":"81","author":"Lazorthes","year":"2006","journal-title":"Handb. Clin. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Eckermann, J.M., Pilitsis, J.G., Vannaboutathong, C., Wagner, B.J., Province-Azalde, R., and Bendel, M.A. (2021). Systematic Literature Review of Spinal Cord Stimulation in Patients with Chronic Back Pain without Prior Spine Surgery. Neuromodulation Technol. Neural Interface.","DOI":"10.1111\/ner.13519"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/ner.13258","article-title":"Using Lower Amplitudes to Maintain Effective High Dose Spinal Cord Stimulation Therapy (SCS Dosing Pilot Study)","volume":"24","author":"Reis","year":"2021","journal-title":"Neuromodulation Technol. Neural Interface"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/papr.13059","article-title":"10 kHz Spinal Cord Stimulation (SCS) for the Treatment of Chronic Peripheral Polyneuropathy (PPN): 12-month Results from Prospective Open-Label Pilot Study","volume":"21","author":"Galan","year":"2021","journal-title":"Pain Pract."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ajps.2019.05.001","article-title":"Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel","volume":"15","author":"Shah","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11916-012-0260-4","article-title":"Spinal cord stimulation: Neurophysiological and neurochemical mechanisms of action","volume":"16","author":"Guan","year":"2012","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/ALN.0b013e31829bd9e2","article-title":"Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain","volume":"119","author":"Shechter","year":"2013","journal-title":"Anesthesiology"},{"key":"ref_66","unstructured":"Botros, D. (2021). Pain Reduction in Chronic Lumbar Patients Using Spinal Cord Stimulation; Theses and Graduate Projects, Augsburg University."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ejpain.2008.01.014","article-title":"Quality of life, resource consumption and costs of spinal cord stimulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial)","volume":"12","author":"Manca","year":"2008","journal-title":"Eur. J. Pain"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/pme.12146","article-title":"Cost-effectiveness of spinal cord stimulation therapy in management of chronic pain","volume":"14","author":"Kumar","year":"2013","journal-title":"Pain Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/ner.12204","article-title":"The appropriate use of neurostimulation: New and evolving neurostimulation therapies and applicable treatment for chronic pain and selected disease states. Neuromodulation Appropriateness Consensus Committee","volume":"17","author":"Deer","year":"2014","journal-title":"Neuromodulation J. Int. Neuromodulation Soc."},{"key":"ref_70","unstructured":"Goudman, L., Duarte, R.V., De Smedt, A., Copley, S., Eldabe, S., and Moens, M. (2021). Cross-Country Differences in Pain Medication Before and After Spinal Cord Stimulation: A Pooled Analysis of Individual Patient Data From Two Prospective Studies in the United Kingdom and Belgium. Neuromodulation Technol. Neural Interface."},{"key":"ref_71","unstructured":"Rana Al-Jumah, M. (2021). Spinal Cord Stimulator Trial in a Patient on Chronic Warfarin Therapy, American Society of Interventional Pain Physicians."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1525-1403.2011.00371.x","article-title":"Spinal cord stimulation versus re-operation in patients with failed back surgery syndrome: An international multicenter randomized controlled trial (EVIDENCE study)","volume":"14","author":"North","year":"2011","journal-title":"Neuromodulation J. Int. Neuromodulation Soc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.10996","article-title":"The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: Two years\u2019 follow-up of the randomized controlled trial","volume":"55","author":"Kemler","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pain.2007.07.028","article-title":"Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome","volume":"132","author":"Kumar","year":"2007","journal-title":"Pain"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Simpson, E.L., Duenas, A., Holmes, M.W., Papaioannou, D., and Chilcott, J. (2009). Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: Systematic review and economic evaluation. Health Technol. Assess., 13.","DOI":"10.3310\/hta13170"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1227\/01.NEU.0000325731.46702.D9","article-title":"The effects of spinal cord stimulation in neuropathic pain are sustained: A 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation","volume":"63","author":"Kumar","year":"2008","journal-title":"Neurosurgery"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/j.pain.2014.08.031","article-title":"Spinal cord stimulation in patients with painful diabetic neuropathy: A multicentre randomized clinical trial","volume":"155","author":"Meier","year":"2014","journal-title":"Pain"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.2337\/dc14-0684","article-title":"Spinal cord stimulation and pain relief in painful diabetic peripheral neuropathy: A prospective two-center randomized controlled trial","volume":"37","author":"Slangen","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/ene.13103","article-title":"EAN guidelines on central neurostimulation therapy in chronic pain conditions","volume":"23","author":"Cruccu","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"ref_80","unstructured":"(2020). 10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain: A Health Technology Assessment. Ont. Health Technol. Assess. Ser., 20, 1\u2013109."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/ner.12721","article-title":"Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy","volume":"21","author":"Chakravarthy","year":"2018","journal-title":"Neuromodulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejpn.2016.07.001","article-title":"Current experience of spinal neuromodulation in chronic pain: Is there a role in children and young people?","volume":"21","author":"Pang","year":"2017","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clineuro.2015.04.014","article-title":"Delayed upper extremity paresthesia post permanent implantation of five lead spinal cord stimulator for low back and lower extremity pain: A case report","volume":"134","author":"Towers","year":"2015","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/AAP.0000000000000029","article-title":"Spinal epidural hematoma after spinal cord stimulator trial lead placement in a patient taking aspirin","volume":"39","author":"Buvanendran","year":"2014","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10877-009-9201-0","article-title":"Spinal cord stimulation: Principles of past, present and future practice: A review","volume":"23","author":"Kunnumpurath","year":"2009","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/ner.12312","article-title":"Treatment-Limiting Complications of Percutaneous Spinal Cord Stimulator Implants: A Review of Eight Years of Experience From an Academic Center Database","volume":"18","author":"Hayek","year":"2015","journal-title":"Neuromodulation J. Int. Neuromodulation Soc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.wneu.2013.06.012","article-title":"Is spinal cord stimulation safe? A review of its complications","volume":"82","author":"Bendersky","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2214\/AJR.10.4789","article-title":"Spinal cord stimulators: Typical positioning and postsurgical complications","volume":"196","author":"Zan","year":"2011","journal-title":"AJR. Am. J. Roentgenol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40122-021-00282-9","article-title":"Spinal Cord Stimulation for Painful Diabetic Peripheral Neuropathy: A Systematic Review","volume":"10","author":"Henson","year":"2021","journal-title":"Pain Ther."},{"key":"ref_90","first-page":"510","article-title":"Active Recharge Burst and Tonic Spinal Cord Stimulation Engage Different Supraspinal Mechanisms: A Functional Magnetic Resonance Imaging Study in Peripherally Injured Chronic Neuropathic Rats","volume":"20","author":"Meuwissen","year":"2020","journal-title":"Pain Pract. Off. J. World Inst. Pain"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1097\/j.pain.0000000000001854","article-title":"Spinal cord stimulation in chronic neuropathic pain: Mechanisms of action, new locations, new paradigms","volume":"161","author":"Joosten","year":"2020","journal-title":"Pain"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/papr.12855","article-title":"Current evidence lacking to guide clinical practice for spinal cord stimulation in the treatment of neuropathic pain in spinal cord injury: A review of the Literature and a Proposal for Future Study","volume":"20","author":"Hunt","year":"2020","journal-title":"Pain Pract."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/ALN.0000000000000774","article-title":"Novel 10-kHz High-frequency Therapy (HF10 Therapy) Is Superior to Traditional Low-frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain: The SENZA-RCT Randomized Controlled Trial","volume":"123","author":"Kapural","year":"2015","journal-title":"Anesthesiology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s12630-015-0356-5","article-title":"Perineural steroids for trauma and compression-related peripheral neuropathic pain: A systematic review and meta-analysis","volume":"62","author":"Bhatia","year":"2015","journal-title":"Can. J. Anaesth.\/J. Can. D\u2019anesthesie"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/AAP.0b013e31828ea086","article-title":"Epidural steroids: A comprehensive, evidence-based review","volume":"38","author":"Cohen","year":"2013","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"373","DOI":"10.7326\/M15-0934","article-title":"Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis: A Systematic Review and Meta-analysis","volume":"163","author":"Chou","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"046014","DOI":"10.1088\/1741-2560\/12\/4\/046014","article-title":"Computational and experimental analysis of TMS-induced electric field vectors critical to neuronal activation","volume":"12","author":"Krieg","year":"2015","journal-title":"J. Neural Eng."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.rehab.2015.05.005","article-title":"Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS)","volume":"58","author":"Klomjai","year":"2015","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e046830","DOI":"10.1136\/bmjopen-2020-046830","article-title":"Protocol: Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: Protocol for a multicentre randomised controlled clinical trial","volume":"11","author":"Enticott","year":"2021","journal-title":"BMJ Open"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.clinph.2014.05.021","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)","volume":"125","author":"Lefaucheur","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1093\/brain\/awg268","article-title":"Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex","volume":"126","author":"Strafella","year":"2003","journal-title":"Brain A J. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnrgo.2021.679033","article-title":"Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity","volume":"2","author":"Turco","year":"2021","journal-title":"Front. Neuroergonomics"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/j.pain.0000000000001760","article-title":"New procedure of high-frequency repetitive transcranial magnetic stimulation for central neuropathic pain: A placebo-controlled randomized crossover study","volume":"161","author":"Quesada","year":"2020","journal-title":"Pain"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1093\/brain\/awab208","article-title":"Repetitive transcranial magnetic stimulation for neuropathic pain: A randomized multicentre sham-controlled trial","volume":"144","author":"Attal","year":"2021","journal-title":"Brain"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neucli.2006.08.002","article-title":"The use of repetitive transcranial magnetic stimulation (rTMS) in chronic neuropathic pain","volume":"36","author":"Lefaucheur","year":"2006","journal-title":"Neurophysiol. Clin.\/Clin. Neurophysiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11916-016-0589-1","article-title":"Invasive and Non-invasive Electrical Pericranial Nerve Stimulation for the Treatment of Chronic Primary Headaches","volume":"20","author":"Magis","year":"2016","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1097\/j.pain.0000000000000401","article-title":"Cortical neurostimulation for neuropathic pain: State of the art and perspectives","volume":"157","author":"Lefaucheur","year":"2016","journal-title":"Pain"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinph.2016.10.087","article-title":"Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)","volume":"128","author":"Lefaucheur","year":"2017","journal-title":"Clin. Neurophysiol. Off. J. Int. Fed. Clin. Neurophysiol."},{"key":"ref_109","first-page":"1537","article-title":"Deep brain stimulation for chronic pain","volume":"22","author":"Boccard","year":"2015","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.nec.2014.07.009","article-title":"Deep brain stimulation for chronic pain: Intracranial targets, clinical outcomes, and trial design considerations","volume":"25","author":"Keifer","year":"2014","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"c1079","DOI":"10.1136\/bmj.c1079","article-title":"Pharmacological management of neuropathic pain in non-specialist settings: Summary of NICE guidance","volume":"340","author":"Tan","year":"2010","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"de Sire, A., Ammendolia, A., Lippi, L., Far\u00ec, G., Cisari, C., and Invernizzi, M. (2021). Percutaneous Electrical Nerve Stimulation (PENS) as a Rehabilitation Approach for Reducing Mixed Chronic Pain in Patients with Musculoskeletal Disorders. Appl. Sci., 11.","DOI":"10.3390\/app11094257"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pmn.2009.08.001","article-title":"Postoperative pain: Acupuncture versus percutaneous electrical nerve stimulation","volume":"13","author":"Gavronsky","year":"2012","journal-title":"Pain Manag. Nurs."},{"key":"ref_114","first-page":"135","article-title":"Effectiveness of Dry Needling with Percutaneous Electrical Nerve Stimulation of High Frequency Versus Low Frequency in Patients with Myofascial Neck Pain","volume":"24","year":"2021","journal-title":"Pain Physician"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2337\/diacare.23.3.365","article-title":"Percutaneous electrical nerve stimulation: A novel analgesic therapy for diabetic neuropathic pain","volume":"23","author":"Hamza","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.2147\/JPR.S226600","article-title":"Remote Analgesic Effects Of Conventional Transcutaneous Electrical Nerve Stimulation: A Scientific And Clinical Review With A Focus On Chronic Pain","volume":"12","author":"Gozani","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/pme.12413","article-title":"The role of the dorsal root ganglion in the development of neuropathic pain","volume":"15","author":"Krames","year":"2014","journal-title":"Pain Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.nec.2014.07.003","article-title":"Peripheral nerve\/field stimulation for chronic pain","volume":"25","author":"Petersen","year":"2014","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/ner.12228","article-title":"One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain","volume":"18","author":"Liem","year":"2015","journal-title":"Neuromodulation J. Int. Neuromodulation Soc."},{"key":"ref_120","first-page":"e8747","article-title":"Cryoablation of the Infrapatellar Branch of the Saphenous Nerve Identified by Non-Invasive Peripheral Nerve Stimulator for the Treatment of Non-Surgical Anterior Knee Pain: A Case Series and Review of the Literature","volume":"12","author":"McLean","year":"2020","journal-title":"Cureus"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/bc.bc_7_17","article-title":"Low-temperature plasma radiofrequency ablation in phantom limb pain: A case report","volume":"4","author":"Li","year":"2018","journal-title":"Brain Circ."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"187","DOI":"10.21037\/atm-20-6190","article-title":"Advances in the interventional management of neuropathic pain","volume":"9","author":"Varshney","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jvir.2015.11.027","article-title":"Cryoneurolysis in Patients with Refractory Chronic Peripheral Neuropathic Pain","volume":"27","author":"Yoon","year":"2016","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"30570","DOI":"10.1038\/srep30570","article-title":"Optogenetic and chemogenetic strategies for sustained inhibition of pain","volume":"6","author":"Iyer","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physrev.00009.2017","article-title":"Chemogenetic Tools for Causal Cellular and Neuronal Biology","volume":"98","author":"Atasoy","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-pharmtox-010814-124803","article-title":"DREADDs (designer receptors exclusively activated by designer drugs): Chemogenetic tools with therapeutic utility","volume":"55","author":"Urban","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.neuron.2015.05.014","article-title":"Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox","volume":"86","author":"Kenny","year":"2015","journal-title":"Neuron"},{"key":"ref_128","first-page":"78","article-title":"Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice","volume":"92","author":"Yi","year":"2020","journal-title":"bioRxiv"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.biopsych.2019.02.018","article-title":"Chemogenetic silencing of the locus coeruleus\u2013basolateral amygdala pathway abolishes pain-induced anxiety and enhanced aversive learning in rats","volume":"85","author":"Bravo","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nbt.2834","article-title":"Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice","volume":"32","author":"Iyer","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/21507740.2014.911213","article-title":"Controlling brain cells with light: Ethical considerations for optogenetic clinical trials","volume":"5","author":"Gilbert","year":"2014","journal-title":"AJOB Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1097\/j.pain.0000000000001506","article-title":"New approach for investigating neuropathic allodynia by optogenetics","volume":"160","author":"Tsuda","year":"2019","journal-title":"Pain"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/jnr.24135","article-title":"Applications of optogenetic and chemogenetic methods to seizure circuits: Where to go next?","volume":"95","author":"Forcelli","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Ju, C., Park, E., Kim, T., Kim, T., Kang, M., Lee, K.S., and Park, S.M. (2020). Effectiveness of electrical stimulation on nerve regeneration after crush injury: Comparison between invasive and non-invasive stimulation. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233531"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Endo-Takahashi, Y., and Negishi, Y. (2020). Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12100964"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Wang, S., Kugelman, T., Buch, A., Herman, M., Han, Y., Karakatsani, M.E., Hussaini, S.A., Duff, K., and Konofagou, E.E. (2017). Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics. Sci. Rep., 7.","DOI":"10.1038\/srep39955"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1566523220999200917114101","article-title":"Exploring the Role of Gene Therapy for Neurological Disorders","volume":"21","author":"Puranik","year":"2021","journal-title":"Curr. Gene Ther."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jcp.24791","article-title":"Gene Therapies for Cancer: Strategies, Challenges and Successes","volume":"230","author":"Das","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12990-015-0018-1","article-title":"Current gene therapy using viral vectors for chronic pain","volume":"11","author":"Guedon","year":"2015","journal-title":"Mol. Pain"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1570159X14666160307145542","article-title":"Current and Future Issues in the Development of Spinal Agents for the Management of Pain","volume":"15","author":"Yaksh","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3344\/kjp.2014.27.3.200","article-title":"Current evidence for spinal opioid selection in postoperative pain","volume":"27","author":"Bujedo","year":"2014","journal-title":"Korean J. Pain"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1744-8069-9-36","article-title":"Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice","volume":"9","author":"Machida","year":"2013","journal-title":"Mol. Pain"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-1-4939-3271-9_18","article-title":"AAV-Mediated Gene Transfer to Dorsal Root Ganglion","volume":"1382","author":"Yu","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"113710","DOI":"10.1016\/j.expneurol.2021.113710","article-title":"Viral vector-mediated gene therapy for opioid use disorders","volume":"341","author":"Wang","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1073\/pnas.0930324100","article-title":"Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: A strategy to increase opioid antinociception","volume":"100","author":"Xu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbi.2020.08.005","article-title":"Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments","volume":"90","author":"Watkins","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/hum.2020.290","article-title":"pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcer: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial","volume":"32","author":"Gu","year":"2021","journal-title":"Hum. Gene Ther."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/mt.2008.213","article-title":"Herpes vector\u2013mediated gene transfer in the treatment of chronic pain","volume":"17","author":"Glorioso","year":"2009","journal-title":"Mol. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/pr.112.007138","article-title":"Mu opioids and their receptors: Evolution of a concept","volume":"65","author":"Pasternak","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1038\/s41386-021-01054-x","article-title":"Pharmacological and genetic manipulations at the \u00b5-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice","volume":"46","author":"He","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_151","first-page":"CD006605","article-title":"Long-term opioid management for chronic noncancer pain","volume":"2010","author":"Noble","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Huang, Y., Liu, X., Dong, L., Liu, Z., He, X., and Liu, W. (2011). Development of viral vectors for gene therapy for chronic pain. Pain Res. Treat., 2011.","DOI":"10.1155\/2011\/968218"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11064-015-1521-5","article-title":"IL-10 and IL-1\u03b2 mediate neuropathic-pain like behavior in the ventrolateral orbital cortex","volume":"40","author":"Shao","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1744-8069-10-49","article-title":"IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats","volume":"10","author":"Zheng","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbi.2014.05.009","article-title":"Decrease in neuroimmune activation by HSV-mediated gene transfer of TNF\u03b1 soluble receptor alleviates pain in rats with diabetic neuropathy","volume":"41","author":"Ortmann","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/j.pain.0000000000001109","article-title":"Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain","volume":"159","author":"Bobinski","year":"2018","journal-title":"Pain"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/00207454.2015.1004172","article-title":"Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons","volume":"126","author":"Yin","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nn.3602","article-title":"Regulating excitability of peripheral afferents: Emerging ion channel targets","volume":"17","author":"Waxman","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-neuro-092920-121538","article-title":"Ion channel degeneracy, variability, and covariation in neuron and circuit resilience","volume":"44","author":"Goaillard","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"114107","DOI":"10.1016\/j.bcp.2020.114107","article-title":"Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases","volume":"181","author":"Cardoso","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4155\/ppa.14.39","article-title":"Inhibitors of voltage-gated sodium channel Nav1. 7: Patent applications since 2010","volume":"3","author":"Sun","year":"2014","journal-title":"Pharm. Pat. Anal."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/bs.ctm.2015.12.005","article-title":"Chapter Eighteen-Unusual Voltage-Gated Sodium Currents as Targets for Pain","volume":"78","author":"Barbosa","year":"2016","journal-title":"Curr. Top. Membr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13023-015-0347-1","article-title":"Primary erythromelalgia: A review","volume":"10","author":"Tang","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2016.05.002","article-title":"Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?","volume":"37","author":"Tibbs","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Zamponi, G.W., Han, C., and Waxman, S.G. (2016). Voltage-Gated Ion Channels as Molecular Targets for Pain. Translational Neuroscience, Springer.","DOI":"10.1007\/978-1-4899-7654-3_22"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/13543784.2020.1728254","article-title":"Neuropathic pain: Preclinical and early clinical progress with voltage-gated sodium channel blockers","volume":"29","author":"Kushnarev","year":"2020","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tips.2004.07.004","article-title":"Targeting Ca 2+ channels to treat pain: T-type versus N-type","volume":"25","author":"Altier","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.conb.2015.08.007","article-title":"Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy","volume":"36","author":"Prescott","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fncel.2021.701105","article-title":"Regulatory Action of Calcium Channels in Pain Pathway","volume":"15","author":"Rajagopal","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1097\/j.pain.0000000000001905","article-title":"Acute visceral pain relief mediated by A3AR agonists in rats: Involvement of N-type voltage-gated calcium channels","volume":"161","author":"Lucarini","year":"2020","journal-title":"Pain"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"24531","DOI":"10.1038\/srep24531","article-title":"Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel \u03b12\u03b4-1-subunit but does not interact with \u03b12\u03b4-1 on the cell-surface when co-expressed","volume":"6","author":"Lana","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/PL00007435","article-title":"Hypoglycaemic neuropathy: Occurrence of axon terminals in plantar skin and plantar muscle of diabetic BB\/Wor rats treated with insulin implants","volume":"99","author":"Mohseni","year":"2000","journal-title":"Acta Neuropathol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1442-2026.2001.00174.x","article-title":"Venom as a source of useful biologically active molecules","volume":"13","author":"Bailey","year":"2001","journal-title":"Emerg. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1021\/acschemneuro.9b00166","article-title":"Reversal of peripheral neuropathic pain by the small-molecule natural product Physalin F via block of CaV2. 3 (R-type) and CaV2. 2 (N-type) voltage-gated calcium channels","volume":"10","author":"Shan","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1744-8069-10-8","article-title":"Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1. 2 in primary afferent neurons","volume":"10","author":"Fan","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/j.pain.0000000000000368","article-title":"Potassium channels in neuropathic pain: Advances, challenges, and emerging ideas","volume":"157","author":"Busserolles","year":"2016","journal-title":"Pain"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jnc.15117","article-title":"Epigenetic restoration of voltage-gated potassium channel Kv1. 2 alleviates nerve injury-induced neuropathic pain","volume":"156","author":"Zhang","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_178","first-page":"1744806919864256","article-title":"Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain","volume":"15","author":"Jackson","year":"2019","journal-title":"Mol. Pain"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/11\/3002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:18:57Z","timestamp":1760138337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/11\/3002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":178,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["jcm11113002"],"URL":"https:\/\/doi.org\/10.3390\/jcm11113002","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}