{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:37:02Z","timestamp":1776976622098,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Obese women are at high risk of developing pre-eclampsia (PE). As an altered angiogenic profile is characteristic for PE, measurement of soluble fms-like tyrosine kinase-1 (sFlt-1)\/placental growth factor (PIGF) ratio in the maternal serum can be helpful for PE diagnosis, as well as for adverse perinatal outcome (APO) prediction. There is growing evidence that obesity might influence the level of sFlt-1\/PIGF and, therefore, the aim of the study was the evaluation of sFlt-1\/PIGF as an APO predictor in obese women with PE. Pre-eclamptic women who had an sFlt-1\/PIGF measurement at the time of diagnosis were retrospectively included. Women were classified according to their pre-pregnancy body mass index (BMI) as normal weight (BMI &lt; 25 kg\/m2), overweight (BMI &gt; 25\u201329.9 kg\/m2) or obese (BMI \u2265 30 kg\/m2). APO was defined as the occurrence of one of the following outcomes: Small for gestational age, defined as a birthweight &lt; 3rd centile, neonatal mortality, neonatal seizures, admission to neonatal unit required (NICU) or respiratory support. A total of 141 women were included. Of them, 28 (20%) patients were obese. ROC (receiver operating characteristic) analysis revealed a high predictive value for sFlt-1\/PIGF and APO across the whole study cohort (AUC = 0.880, 95% CI: 0.826\u20130.936; p &lt; 0.001). However, the subgroup of obese women showed a significantly lower level of sFlt-1 and, therefore, the performance of sFlt-1\/PIGF as APO predictor was poorer compared to normal or overweight PE women (AUC = 0.754, 95% CI: 0.552\u20130.956, p = 0.025). In contrast to normal or overweight women, a ratio of sFlt-1\/PIGF &lt; 38 could not rule out APO in women with obesity.<\/jats:p>","DOI":"10.3390\/jcm11113023","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:05:07Z","timestamp":1653635107000},"page":"3023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Performance of sFlt-1\/PIGF Ratio for the Prediction of Perinatal Outcome in Obese Pre-Eclamptic Women"],"prefix":"10.3390","volume":"11","author":[{"given":"Anne","family":"Karge","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linus","family":"Desing","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-393X","authenticated-orcid":false,"given":"Bernhard","family":"Haller","sequence":"additional","affiliation":[{"name":"Institute of AI and Informatics in Medicine, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier U.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5696-6686","authenticated-orcid":false,"given":"Silvia M.","family":"Lobmaier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Kuschel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Graupner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"},{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen, RWTH University, 52062 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: A systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1080\/14767058.2016.1263295","article-title":"Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity","volume":"30","year":"2017","journal-title":"J. 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