{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:35:19Z","timestamp":1768815319099,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia (CDH). Echocardiography is widely established to quantify PH severity, but currently used parameters have inherent limitations. The aim of our study was to investigate the prognostic utility of the index of the pulmonary artery acceleration time to the right ventricular ejection time (PAAT:ET) in CDH neonates assessed using echocardiography. Methods: PAAT:ET values were prospectively measured in CDH neonates on admission, on day of life (DOL) 2 and DOL 5\u20137. Optimal cut-off values to predict mortality and need for ECMO were calculated and PAAT:ET values were compared between non-ECMO survivors, ECMO-survivors, and ECMO-non-survivors. Results: 87 CDH neonates were enrolled and 39 patients required ECMO therapy. At baseline, PAAT:ET values were significantly lower in ECMO patients compared to non-ECMO patients (p &lt; 0.001). ECMO survivors and ECMO non-survivors had similar values at baseline (p = 0.967) and DOL 2 (p = 0.124) but significantly higher values at DOL 5\u20137 (p = 0.003). Optimal PAAT:ET cut-off for predicting ECMO was 0.290 at baseline and 0.310 for predicting non-survival in patients on ECMO at DOL 5\u20137. Conclusion: PAAT:ET is a feasible parameter for early risk assessment in CDH neonates.<\/jats:p>","DOI":"10.3390\/jcm11113038","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:40:45Z","timestamp":1653702045000},"page":"3038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-757X","authenticated-orcid":false,"given":"Florian","family":"Kipfmueller","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"},{"name":"Center for Rare Diseases Bonn, Division of Congenital Malformations, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suemeyra","family":"Akkas","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-6778","authenticated-orcid":false,"given":"Flaminia","family":"Pugnaloni","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"},{"name":"Department of Neonatology, Ospidale Bambinu Gesu, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolomeo","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte","family":"Lemloh","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-4669","authenticated-orcid":false,"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"},{"name":"Division of Prenatal Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heydweiller","sequence":"additional","affiliation":[{"name":"Center for Rare Diseases Bonn, Division of Congenital Malformations, University of Bonn, 53113 Bonn, Germany"},{"name":"Division of Pediatric Surgery, Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, 53113 Bonn, Germany"},{"name":"Center for Rare Diseases Bonn, Division of Congenital Malformations, University of Bonn, 53113 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F137","DOI":"10.1136\/archdischild-2014-306174","article-title":"Epidemiology of congenital diaphragmatic hernia in Europe: A register-based study","volume":"100","author":"McGivern","year":"2015","journal-title":"Arch. 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