{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:25:19Z","timestamp":1791645919372,"version":"4.3.4"},"reference-count":169,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]},{"name":"Japan Agency for Medical Research and Development (AMED) [e-ASIA JRP, Science and Technology Research Partnership for Sustainable Development (SATREPS), Global Alliance for Chronic Diseases (GACD)]","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Japan Agency for Medical Research and Development (AMED) [e-ASIA JRP, Science and Technology Research Partnership for Sustainable Development (SATREPS), Global Alliance for Chronic Diseases (GACD)]","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Japan Agency for Medical Research and Development (AMED) [e-ASIA JRP, Science and Technology Research Partnership for Sustainable Development (SATREPS), Global Alliance for Chronic Diseases (GACD)]","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]},{"name":"Japan International Cooperation Agency (JICA) [SATREPS]","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Japan International Cooperation Agency (JICA) [SATREPS]","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Japan International Cooperation Agency (JICA) [SATREPS]","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]},{"name":"Thailand Science Research and Innovation Fundamental Fund","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Thailand Science Research and Innovation Fundamental Fund","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Thailand Science Research and Innovation Fundamental Fund","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]},{"name":"Bualuang ASEAN Chair Professorship at Thammasat University","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Bualuang ASEAN Chair Professorship at Thammasat University","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Bualuang ASEAN Chair Professorship at Thammasat University","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]},{"name":"Center of Excellence in Digestive Diseases, Thammasat University, Thailand","award":["DK62813"],"award-info":[{"award-number":["DK62813"]}]},{"name":"Center of Excellence in Digestive Diseases, Thammasat University, Thailand","award":["18KK0266"],"award-info":[{"award-number":["18KK0266"]}]},{"name":"Center of Excellence in Digestive Diseases, Thammasat University, Thailand","award":["19H03473"],"award-info":[{"award-number":["19H03473"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Helicobacter pylori colonize the gastric mucosa of at least half of the world\u2019s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models.<\/jats:p>","DOI":"10.3390\/jcm11113141","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T03:33:18Z","timestamp":1654054398000},"page":"3141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Animal Models and Helicobacter pylori Infection"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-1377","authenticated-orcid":false,"given":"Shamshul","family":"Ansari","sequence":"first","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-5819","authenticated-orcid":false,"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan"},{"name":"Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","article-title":"Clinical practice: Helicobacter pylori infection","volume":"362","author":"McColl","year":"2010","journal-title":"N. 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