{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:15:11Z","timestamp":1789103711919,"version":"build-2803163510"},"reference-count":80,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mastocytosis, a heterogeneous mastcell disease, include three different entities: cutaneous mastocytosis, systemic mastocytosis (SM) and mast-cell sarcoma. Tryptase levels can differentiate cutaneous mastocytosis from SM. In mastocytosis, quick onset drug hypersensitivity reactions (DHRs) that are facilitated by mastcell mediators, are investigated in adults. Due to the limited number of children with mastcell disease and increased serum tryptase levels, the role of drugs in this age group is less studied. In this review, we critically assessed relevant papers related with immediate DHRs in children with mastocytosis and discuss practical issues of the management. In childhood mastocytosis, anaphylaxis is frequently idiopathic, and elevated level of basal tryptase, and high burden of disease may increase the risk. Among drugs, antibiotics, NSAIDs and opioids can potentially induce anaphylaxis, anyway avoidance should be recommended only in case of previous reactions. Moreover, vaccinations are not contraindicated in patients with mastocytosis. The risk of severe systemic reactions after drugs intake seems to be extremely low and in general lower in children than in adults. Anyway, studies on this topic especially focusing on children, are missing to state final recommendations.<\/jats:p>","DOI":"10.3390\/jcm11113153","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:48:31Z","timestamp":1654087711000},"page":"3153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Drugs and Vaccines Hypersensitivity in Children with Mastocytosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Francesca","family":"Mori","sequence":"first","affiliation":[{"name":"Allergologia, Dipartimento di Pediatria, Ospedale Anna Meyer, 50132 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Crisafulli","sequence":"additional","affiliation":[{"name":"UOC di Pediatria, Dipartimento Materno-Infantile, Universit\u00e0 di Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Bianchi","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Ospedale San Camillo Forlanini, 00152 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bottau","sequence":"additional","affiliation":[{"name":"Pediatria e Neonatologia, Ospedale di Imola (BO), 40026 Imola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Caimmi","sequence":"additional","affiliation":[{"name":"UOC Pediatria Fondazione IRCSS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-9113","authenticated-orcid":false,"given":"Fabrizio","family":"Franceschini","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Azienda Ospedaliero-Universitaria \u201cOspedali Riuniti\u201d, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Liotti","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Azienda Ospedaliero-Universitaria \u201cOspedali Riuniti\u201d, 60123 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Paglialunga","sequence":"additional","affiliation":[{"name":"UOC di Pediatria, Azienda Ospedaliera-Universitaria Consorziale \u201cPoliclinico-Ospedale Pediatrico Giovanni XXIII\u201d, 70120 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-5483","authenticated-orcid":false,"given":"Francesca","family":"Saretta","sequence":"additional","affiliation":[{"name":"SC Pediatria, Ospedale Latisana-Palmanova, Dipartimento Materno-Infantile Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caffarelli","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica, Dipartimento Medicina e Chirurgia, Universit\u00e0 di Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MOP.0000000000000922","article-title":"Pediatric mastocytosis","volume":"32","author":"Hussain","year":"2020","journal-title":"Curr. 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