{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:09Z","timestamp":1790957709050,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction and fibrosis of skin and visceral organs. In the last decade, attention has been focused on the macrovascular involvement of the disease. In particular, the observation of increased arterial stiffness represented an interesting aspect of the disease, as predictor of cardiovascular risk. (2) Methods: We recruited 60 SSc patients (52 \u00b1 12 years old, 90% females) and 150 age\/sex-matched healthy controls in order to evaluate both intima-media thickness of the right common carotid artery and arterial stiffness using the B-mode echography and the SphygmoCor system\u00ae tonometer. (3) Results: The carotid-femoral pulse wave velocity (PWV) was higher in SSc patients than in controls (8.6 \u00b1 1.7 vs. 7.8 \u00b1 1.5 m\/s; p &lt; 0.001), as was the carotid-radial PWV (7.8 \u00b1 1.1 vs. 6.7 \u00b1 1.4 m\/s; p &lt; 0.001). The intima-media thickness was higher in SSc than in controls (654 \u00b1 108 vs. 602 \u00b1 118 \u00b5m; p = 0.004). The other parameters measured at carotid (radial strain, Young\u2019s modulus, compliance and distensibility) all indicated that arterial stiffness in tension was more pronounced in SSc. Of interest, the direct correlation between PWV and age corresponded closely in SSc. Moreover, a significant difference between SSc and controls as regards the carotid parameters was evident in younger subjects. (4) Conclusions: SSc patients showed an increased arterial stiffness compared to healthy controls. In particular, an SSc-related pathologic effect was suggested by the more pronounced increase in PWV with age and lower values of carotid elasticity in younger SSc patients than in age-matched controls.<\/jats:p>","DOI":"10.3390\/jcm11123256","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T02:25:33Z","timestamp":1654827933000},"page":"3256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Impaired Elasticity of Large Arteries in Systemic Sclerosis Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-3404","authenticated-orcid":false,"given":"Michele","family":"Colaci","sequence":"first","affiliation":[{"name":"Rheumatology Clinic, Internal Medicine Unit, AOE Cannizzaro, 95126 Catania, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-3778","authenticated-orcid":false,"given":"Luca","family":"Zanoli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"},{"name":"Internal Medicine Unit, Policlinico Rodolico\u2014S. Marco, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-0314","authenticated-orcid":false,"given":"Alberto","family":"Lo Gullo","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, ARNAS Garibaldi, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-1202","authenticated-orcid":false,"given":"Gianluca","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Aprile","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic, Internal Medicine Unit, AOE Cannizzaro, 95126 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"},{"name":"Internal Medicine Unit, Policlinico Rodolico\u2014S. Marco, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-2729","authenticated-orcid":false,"given":"Lorenzo","family":"Malatino","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic, Internal Medicine Unit, AOE Cannizzaro, 95126 Catania, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: Current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104087","DOI":"10.1016\/j.lpm.2021.104087","article-title":"Pathophysiology of systemic sclerosis","volume":"50","author":"Thoreau","year":"2021","journal-title":"Press. Med."},{"key":"ref_3","first-page":"400","article-title":"Atteintes macrovasculaires de la scl\u00e9rodermie: \u00c9tat de la question en 2019 [Systemic sclerosis and macrovascular involvement: Status of the issue in 2019]","volume":"44","author":"Bertolino","year":"2019","journal-title":"J. Med. Vasc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00296-016-3530-3","article-title":"A critical view on cardiovascular risk in systemic sclerosis","volume":"37","author":"Psarras","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/rheumatology\/kew236","article-title":"Early morphologic and functional changes of atherosclerosis in systemic sclerosis-a systematic review and meta-analysis","volume":"55","author":"Meiszterics","year":"2016","journal-title":"Rheumatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/art.37988","article-title":"Review: Evidence that systemic sclerosis is a vascular disease","volume":"65","author":"Kahaleh","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2019.07.012","article-title":"Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review","volume":"74","author":"Chirinos","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jacc.2010.12.017","article-title":"Aortic stiffness: Current understanding and future directions","volume":"57","author":"Cavalcante","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/HYPERTENSIONAHA.117.09097","article-title":"Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis","volume":"69","author":"Ohkuma","year":"2017","journal-title":"Hypertension"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1007\/s10067-021-05795-4","article-title":"Peripheral microcirculatory abnormalities are associated with cardiovascular risk in systemic sclerosis: A nailfold video capillaroscopy study","volume":"40","author":"Pagkopoulou","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.55563\/clinexprheumatol\/243mpp","article-title":"Evaluation of endothelial dysfunction and clinical events in patients with early-stage vasculopathy in limited systemic sclerosis","volume":"39","author":"Jud","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1161\/HYPERTENSIONAHA.116.08345","article-title":"Central Hemodynamics and Arterial Stiffness in Systemic Sclerosis","volume":"68","author":"Bartoloni","year":"2016","journal-title":"Hypertension"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/03009742.2015.1021710","article-title":"Assessment of systemic and pulmonary arterial remodelling in women with systemic sclerosis","volume":"44","author":"Irzyk","year":"2015","journal-title":"Scand. J. Rheumatol."},{"key":"ref_14","first-page":"S161","article-title":"Arterial stiffness is increased in systemic sclerosis: A cross-sectional comparison with matched controls","volume":"32","author":"Ngian","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.5543\/tkda.2014.03162","article-title":"Evaluation of aortic elastic properties in patients with systemic sclerosis","volume":"42","author":"Karaaslan","year":"2014","journal-title":"Turk Kardiyol. Dern. Ars."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00508-013-0396-1","article-title":"Evaluation of arterial stiffness and hemodynamics by oscillometric method in patients with systemic sclerosis","volume":"125","author":"Sunbul","year":"2013","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/acr.21819","article-title":"Silent cardiovascular involvement in patients with diffuse systemic sclerosis: A controlled cross-sectional study","volume":"65","author":"Turiel","year":"2013","journal-title":"Arthritis Care Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4081\/reumatismo.2012.360","article-title":"Aortic pulse wave velocity measurement in systemic sclerosis patients","volume":"64","author":"Colaci","year":"2012","journal-title":"Reumatismo"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/acr.20306","article-title":"Preferential macrovasculopathy in systemic sclerosis detected by regional pulse wave velocity from wave intensity analysis: Comparisons of local and regional arterial stiffness parameters in cases and controls","volume":"63","author":"Liu","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10067-009-1118-y","article-title":"A comparative study of arterial stiffness, flow-mediated vasodilation of the brachial artery, and the thickness of the carotid artery intima-media in patients with systemic autoimmune diseases","volume":"28","author":"Kerekes","year":"2009","journal-title":"Clin. Rheumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s10067-008-0958-1","article-title":"The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function","volume":"27","author":"Cypiene","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"ref_22","first-page":"1329","article-title":"Increased arterial stiffness as the marker of vascular involvement in systemic sclerosis","volume":"35","author":"Szamosi","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s40292-019-00318-4","article-title":"Vascular Aging and Disease of the Large Vessels: Role of Inflammation","volume":"26","author":"Maloberti","year":"2019","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: An American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"Khanna","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/bmj.322.7285.531","article-title":"Blood pressure measuring devices: Recommendations of the European Society of Hypertension","volume":"322","author":"Waeber","year":"2001","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1097\/HJH.0000000000002007","article-title":"Increased carotid stiffness and remodelling at early stages of chronic kidney disease","volume":"37","author":"Zanoli","year":"2019","journal-title":"J. Hypertens."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: Methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejim.2017.08.020","article-title":"Pulse wave velocity differs between ulcerative colitis and chronic kidney disease","volume":"47","author":"Zanoli","year":"2018","journal-title":"Eur. J. Int. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/HJH.0b013e32834fa8b0","article-title":"Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity","volume":"30","author":"Laurent","year":"2012","journal-title":"J. Hypertens."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4250\/jcu.2016.24.3.215","article-title":"The Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography","volume":"24","author":"Yoon","year":"2016","journal-title":"J. Cardiovasc. Ultrasound"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s10067-019-04427-2","article-title":"Established coronary artery disease in systemic sclerosis compared to type 2 diabetic female patients: A cross-sectional study","volume":"38","author":"Colaci","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.autrev.2021.102925","article-title":"Systematic review and meta-analysis of cardiovascular risk in rheumatological disease: Symptomatic and non-symptomatic events in rheumatoid arthritis and systemic lupus erythematosus","volume":"21","author":"Restivo","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Rezu\u0219, E., Macovei, L.A., Burlui, A.M., Cardoneanu, A., and Rezu\u0219, C. (2021). Ischemic Heart Disease and Rheumatoid Arthritis-Two Conditions, the Same Background. Life, 11.","DOI":"10.3390\/life11101042"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/HCO.0000000000000877","article-title":"Cardiovascular disease prevention in individuals with underlying chronic inflammatory disease","volume":"36","author":"Weber","year":"2021","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2217\/ijr.15.33","article-title":"Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions","volume":"10","author":"Hong","year":"2015","journal-title":"Int. J. Clin. Rheumatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11883-022-01023-9","article-title":"More than Just a Monolayer: The Multifaceted Role of Endothelial Cells in the Pathophysiology of Atherosclerosis","volume":"24","author":"Mussbacher","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10067-020-05201-5","article-title":"Aortic root dilation is associated with the reduction in capillary density observed at nailfold capillaroscopy in SSc patients","volume":"40","author":"Colaci","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13075-019-2051-3","article-title":"Arterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis: Results from a cross-sectional study","volume":"21","author":"Soulaidopoulos","year":"2019","journal-title":"Arthritis Res. Ther."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/12\/3256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:25:32Z","timestamp":1760138732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/12\/3256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["jcm11123256"],"URL":"https:\/\/doi.org\/10.3390\/jcm11123256","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]}}}