{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:05:44Z","timestamp":1767924344799,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Emergency Medicine and Services, Helsinki University Hospital (HUS), Haartmaninkatu 4, PL 340, 00029 HUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Emergency department (ED) overcrowding is a global issue setting challenges to all care providers. Elderly patients are frequent visitors of the ED and their risk stratification is demanding due to insufficient assessment methods. A prospective cohort study was conducted to determine the risk-predicting value of a prognostic biomarker, soluble urokinase plasminogen activator receptor (suPAR), in the ED, concentrating on elderly patients. SuPAR levels were determined as part of standard blood sampling of 1858 ED patients. The outcomes were assessed in the group of &lt;75 years (=younger) and \u226575 years (=elderly). The elderly had higher median suPAR levels than the younger (5.4 ng\/mL vs. 3.7 ng\/mL, p &lt; 0.001). Increasing suPAR levels were associated with higher probability for 30-day mortality and hospital admission in all age groups. SuPAR also predicted 30-day mortality when adjusted to other clinical factors. SuPAR acts successfully as a nonspecific risk predictor for 30-day mortality, independently and with other risk-assessment tools. Low suPAR levels predict positive outcomes and could be used in the discharging process. A cut-off value of 4 ng\/mL could be used for all ED patients, 5 ng\/mL being a potential alternative in elderly patients.<\/jats:p>","DOI":"10.3390\/jcm11123283","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T02:25:33Z","timestamp":1654827933000},"page":"3283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Emergency Department (Ed): A Tool for the Assessment of Elderly Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-6592","authenticated-orcid":false,"given":"Ria M.","family":"Holstein","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Helsinki, 00350 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santeri","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"South Savo Social- and Healthcare District, Mikkeli Central Hospital, 50100 Mikkeli, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Kaartinen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Services, Faculty of Medicine, University of Helsinki, Haartmaninkatu 4, PL 340, 00029 HUS, 00350 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Hongisto","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Services, Faculty of Medicine, University of Helsinki, Haartmaninkatu 4, PL 340, 00029 HUS, 00350 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-3462","authenticated-orcid":false,"given":"Harri","family":"Hypp\u00f6l\u00e4","sequence":"additional","affiliation":[{"name":"South Savo Social- and Healthcare District, Mikkeli Central Hospital, 50100 Mikkeli, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaret","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Services, Faculty of Medicine, University of Helsinki, Haartmaninkatu 4, PL 340, 00029 HUS, 00350 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1553-2712.2011.01235.x","article-title":"International perspectives on emergency department crowding","volume":"18","author":"Pines","year":"2011","journal-title":"Acad. 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