{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T03:21:00Z","timestamp":1762053660955,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the macroscopic complete resection, obtained by either extrapleural pneumonectomy or pleurectomy\/decortication. Failure, in local and\/or distant sites, is one of the major concerns; in fact, there has been no established treatment for the recurrence of MPM after the multimodal approach, and the role of surgery in this context is still controversial. By using electronic databases, studies that included recurrent MPM patients who underwent a second surgery were identified. The endpoints included were: a pattern of recurrence, post-recurrence survival (PRS), and the type of second surgery. When available, factors predicting better PRS and perioperative mortality and morbidity were collected. This systematic review offers an overview of the results that are currently obtained in patients undergoing a second surgery for relapsed MPM, with the aim to provide a comprehensive view on this subject that explores if a second surgery leads to an improvement in survival.<\/jats:p>","DOI":"10.3390\/jcm11123340","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:25:12Z","timestamp":1654856712000},"page":"3340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-6855","authenticated-orcid":false,"given":"Alice","family":"Bellini","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, G.B. Morgagni\u2014L. Pierantoni Hospital, Via Carlo Forlanini n.34, 47121 Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mazzarra","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, G.B. Morgagni\u2014L. Pierantoni Hospital, Via Carlo Forlanini n.34, 47121 Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sterrantino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, G.B. Morgagni\u2014L. Pierantoni Hospital, Via Carlo Forlanini n.34, 47121 Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desideria","family":"Argnani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, G.B. Morgagni\u2014L. Pierantoni Hospital, Via Carlo Forlanini n.34, 47121 Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Stella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, G.B. Morgagni\u2014L. Pierantoni Hospital, Via Carlo Forlanini n.34, 47121 Forl\u00ec, Italy"},{"name":"Department of Diagnostic and Specialty Medicine\u2014DIMES of the Alma Mater Studiorum, Division of Thoracic Surgery, University of Bologna, G.B. Morgagni\u2014L. Pierantoni Hospital, via Carlo Forlanini n. 34, 47121 Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"ref_1","unstructured":"(2022, February 01). Associazione Italiana di Oncologia Medica (AIOM). Linee Guida Mesotelioma Pleurico. Edizione. 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