{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:43:02Z","timestamp":1790347382705,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["HU20C0271"],"award-info":[{"award-number":["HU20C0271"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["HU21C0016"],"award-info":[{"award-number":["HU21C0016"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["NRF-2018M3C7A1057137"],"award-info":[{"award-number":["NRF-2018M3C7A1057137"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["NRF-2020M3E5D2A01084721"],"award-info":[{"award-number":["NRF-2020M3E5D2A01084721"]}]},{"name":"Ministry of Science and ICT","award":["HU20C0271"],"award-info":[{"award-number":["HU20C0271"]}]},{"name":"Ministry of Science and ICT","award":["HU21C0016"],"award-info":[{"award-number":["HU21C0016"]}]},{"name":"Ministry of Science and ICT","award":["NRF-2018M3C7A1057137"],"award-info":[{"award-number":["NRF-2018M3C7A1057137"]}]},{"name":"Ministry of Science and ICT","award":["NRF-2020M3E5D2A01084721"],"award-info":[{"award-number":["NRF-2020M3E5D2A01084721"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The presence of amyloid-\u03b2 (A\u03b2) deposition is considered important in patients with amnestic mild cognitive impairment (aMCI), since they can progress to Alzheimer\u2019s disease dementia. Amyloid positron emission tomography (PET) has been used for detecting A\u03b2 deposition, but its high cost is a significant barrier for clinical usage. Therefore, we aimed to develop a new predictive scale for amyloid PET positivity using easily accessible tools. Overall, 161 aMCI patients were recruited from six memory clinics and underwent neuropsychological tests, brain magnetic resonance imaging (MRI), apolipoprotein E (APOE) genotype testing, and amyloid PET. Among the potential predictors, verbal and visual memory tests, medial temporal lobe atrophy, APOE genotype, and age showed significant differences between the A\u03b2-positive and A\u03b2-negative groups and were combined to make a model for predicting amyloid PET positivity with the area under the curve (AUC) of 0.856. Based on the best model, we developed the new predictive scale comprising integers, which had an optimal cutoff score \u2265 3. The new predictive scale was validated in another cohort of 98 participants and showed a good performance with AUC of 0.835. This new predictive scale with accessible variables may be useful for predicting A\u03b2 positivity in aMCI patients in clinical practice.<\/jats:p>","DOI":"10.3390\/jcm11123433","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:01:22Z","timestamp":1655348482000},"page":"3433","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictive Scale for Amyloid PET Positivity Based on Clinical and MRI Variables in Patients with Amnestic Mild Cognitive Impairment"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-6132","authenticated-orcid":false,"given":"Min Young","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-1924","authenticated-orcid":false,"given":"Geon Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Korea"},{"name":"Division of Psychiatry, Department of Mental Health Care of Older People, University College London, London W1T 7NF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-5704","authenticated-orcid":false,"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine & Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inha University School of Medicine, Inchon 22232, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment","volume":"58","author":"Petersen","year":"2001","journal-title":"Arch. 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