{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:38:52Z","timestamp":1790912332897,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"publisher","award":["DS43"],"award-info":[{"award-number":["DS43"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A growing body of evidence indicates a crucial role of miRNA regulatory function in a variety of mechanisms that contribute to the development of diseases. In our previous work, alterations in miRNA expression levels and targeted genes were shown in peripheral blood mononuclear cells (PBMCs) from patients with lower extremity artery disease (LEAD), abdominal aortic aneurysm (AAA), and chronic venous disease (CVD) in comparison with healthy controls. In this paper, previously obtained miRNA expression profiles were compared between the LEAD, AAA, and CVD groups to find either similarities or differences within the studied diseases. Differentially expressed miRNAs were identified using the DESeq2 method implemented in the R programming software. Pairwise comparisons (LEAD vs. AAA, LEAD vs. CVD, and AAA vs. CVD) were performed and revealed 10, 8, and 17 differentially expressed miRNA transcripts, respectively. The functional analysis of the obtained miRNAs was conducted using the miRNet 2.0 online tool and disclosed associations with inflammation and cellular differentiation, motility, and death. The miRNet 2.0 tool was also used to identify regulatory interactions between dysregulated miRNAs and target genes in patients with LEAD, AAA, and CVD. The presented research provides new information about similarities and differences in the miRNA-dependent regulatory mechanisms involved in the pathogenesis of LEAD, AAA, and CVD.<\/jats:p>","DOI":"10.3390\/jcm11123470","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:25:11Z","timestamp":1655443511000},"page":"3470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["miRNA Regulatory Networks Associated with Peripheral Vascular Diseases"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-2009","authenticated-orcid":false,"given":"Daniel","family":"Zalewski","sequence":"first","affiliation":[{"name":"Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chod\u017aki St., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Ruszel","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Chair of Medical Genetics, Medical University of Lublin, 11 Radziwi\u0142\u0142owska St., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"St\u0119pniewski","sequence":"additional","affiliation":[{"name":"Ecotech Complex Analytical and Programme Centre for Advanced Environmentally Friendly Technologies, University of Marie Curie-Sk\u0142odowska, 39 G\u0142\u0119boka St., 20-612 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Ga\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ 08903-0019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Feldo","sequence":"additional","affiliation":[{"name":"Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, 11 Staszica St., 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-6353","authenticated-orcid":false,"given":"Janusz","family":"Kocki","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Chair of Medical Genetics, Medical University of Lublin, 11 Radziwi\u0142\u0142owska St., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-7429","authenticated-orcid":false,"given":"Anna","family":"Bogucka-Kocka","sequence":"additional","affiliation":[{"name":"Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chod\u017aki St., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/ng.3694","article-title":"General Rules for Functional MicroRNA Targeting","volume":"48","author":"Kim","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An Overview of MicroRNAs: Biology, Functions, Therapeutics, and Analysis Methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA Therapeutics: Towards a New Era for the Management of Cancer and Other Diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107296","DOI":"10.1016\/j.carpath.2020.107296","article-title":"MicroRNAs: Roles in Cardiovascular Development and Disease","volume":"50","author":"Kalayinia","year":"2021","journal-title":"Cardiovasc. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Munjas, J., Sopi\u0107, M., Stefanovi\u0107, A., Ko\u0161ir, R., Nini\u0107, A., Joksi\u0107, I., Antoni\u0107, T., Spasojevi\u0107-Kalimanovska, V., and Prosenc Zmrzljak, U. (2021). Non-Coding RNAs in Preeclampsia\u2014Molecular Mechanisms and Diagnostic Potential. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910652"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in Collaboration with the European Society for Vascular Surgery (ESVS)","volume":"39","author":"Aboyans","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1253\/circj.CJ-16-1286","article-title":"Pathophysiology of Intermittent Claudication in Peripheral Artery Disease","volume":"81","author":"Hamburg","year":"2017","journal-title":"Circ. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, Regional, and National Prevalence and Risk Factors for Peripheral Artery Disease in 2015: An Updated Systematic Review and Analysis","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on Peripheral Artery Disease: Epidemiology and Evidence-Based Facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jvs.2014.03.290","article-title":"Epidemiology of Peripheral Arterial Disease and Critical Limb Ischemia in an Insured National Population","volume":"60","author":"Nehler","year":"2014","journal-title":"J. Vasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jvs.2017.10.044","article-title":"The Society for Vascular Surgery Practice Guidelines on the Care of Patients with an Abdominal Aortic Aneurysm","volume":"67","author":"Chaikof","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/joim.13060","article-title":"Abdominal Aortic Aneurysms: Pathophysiology and Clinical Issues","volume":"288","author":"Lattanzi","year":"2020","journal-title":"J. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jvs.2010.05.090","article-title":"Analysis of Risk Factors for Abdominal Aortic Aneurysm in a Cohort of More than 3 Million Individuals","volume":"52","author":"Kent","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/CRD.0000000000000052","article-title":"Abdominal Aortic Aneurysms and Risk Factors for Adverse Events","volume":"24","author":"Ahmed","year":"2016","journal-title":"Cardiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Murali Krishna, S., Morton, S.K., Li, J., and Golledge, J. (2020). Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197250"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.113.006898","article-title":"Chronic Venous Insufficiency","volume":"130","author":"Eberhardt","year":"2014","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ligi, D., Croce, L., and Mannello, F. (2018). Chronic Venous Disorders: The Dangerous, the Good, and the Diverse. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092544"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.23736\/S0392-9590.18.03999-8","article-title":"Management of Chronic Venous Disorders of the Lower Limbs. Guidelines According to Scientific Evidence. Part I","volume":"37","author":"Nicolaides","year":"2018","journal-title":"Int. Angiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.23736\/S0392-9590.20.04388-6","article-title":"Management of Chronic Venous Disorders of the Lower Limbs. Guidelines According to Scientific Evidence. Part II","volume":"39","author":"Nicolaides","year":"2020","journal-title":"Int. Angiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mansilha, A., and Sousa, J. (2018). Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061669"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jvsv.2019.12.075","article-title":"The 2020 Update of the CEAP Classification System and Reporting Standards","volume":"8","author":"Lurie","year":"2020","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/0003319718759834","article-title":"An Epidemiological Survey of Venous Disease Among General Practitioner Attendees in Different Geographical Regions on the Globe: The Final Results of the Vein Consult Program","volume":"69","author":"Vuylsteke","year":"2018","journal-title":"Angiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejvs.2015.02.007","article-title":"Editor\u2019s Choice\u2014Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)","volume":"49","author":"Wittens","year":"2015","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/FJC.0b013e318203759b","article-title":"MicroRNAs in Vascular Disease","volume":"57","author":"Qin","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MOH.0000000000000424","article-title":"MicroRNAs in Endothelial Cell Homeostasis and Vascular Disease","volume":"25","year":"2018","journal-title":"Curr. Opin. Hematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1111\/febs.15678","article-title":"Functional Non-Coding RNAs in Vascular Diseases","volume":"288","author":"Ono","year":"2020","journal-title":"FEBS J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vph.2018.10.001","article-title":"Role of Flow-Sensitive MicroRNAs and Long Noncoding RNAs in Vascular Dysfunction and Atherosclerosis","volume":"114","author":"Kumar","year":"2019","journal-title":"Vascul. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.coph.2018.04.001","article-title":"Peripheral Artery Disease: A Micro-RNA-Related Condition?","volume":"39","author":"Vogiatzi","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/15701611113119990014","article-title":"Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease","volume":"13","author":"Hamburg","year":"2015","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2017.03.010","article-title":"A Systematic Review Investigating the Association of MicroRNAs with Human Abdominal Aortic Aneurysms","volume":"261","author":"Iyer","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1620\/tjem.228.341","article-title":"MicroRNA Profiling in Great Saphenous Vein Tissues of Patients with Chronic Venous Insufficiency","volume":"228","author":"Cui","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1002\/jcb.28287","article-title":"Augmentation of MiR-202 in Varicose Veins Modulates Phenotypic Transition of Vascular Smooth Muscle Cells by Targeting Proliferator\u2013Activated Receptor-\u03b3 Coactivator-1\u03b1","volume":"120","author":"Huang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1038\/s41598-017-02529-y","article-title":"A Comprehensive Characterisation of the Metabolic Profile of Varicose Veins; Implications in Elaborating Plausible Cellular Pathways for Disease Pathogenesis","volume":"7","author":"Anwar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Saenz-Pipaon, G., Martinez-Aguilar, E., Orbe, J., Gonz\u00e1lez Miqueo, A., Fernandez-Alonso, L., Paramo, J.A., and Roncal, C. (2021). The Role of Circulating Biomarkers in Peripheral Arterial Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073601"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Barbalata, T., Moraru, O.E., Stancu, C.S., Devaux, Y., Simionescu, M., Sima, A.V., and Niculescu, L.S. (2020). Increased MiR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249600"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Plana, E., G\u00e1lvez, L., Medina, P., Navarro, S., Forn\u00e9s-Ferrer, V., Panadero, J., and Miralles, M. (2020). Identification of Novel MicroRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134600"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Torres-Do Rego, A., Barrientos, M., Ortega-Hern\u00e1ndez, A., Modrego, J., G\u00f3mez-Gordo, R., \u00c1lvarez-Sala, L.A., Cachofeiro, V., and G\u00f3mez-Garre, D. (2020). Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092783"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Nana, P., Dakis, K., Brodis, A., Spanos, K., and Kouvelos, G. (2021). Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081718"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zalewski, D.P., Ruszel, K.P., St\u0119pniewski, A., Ga\u0142kowski, D., Bogucki, J., Komsta, \u0141., Ko\u0142odziej, P., Chmiel, P., Zubilewicz, T., and Feldo, M. (2020). Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051251"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3389\/fgene.2019.01200","article-title":"Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease","volume":"10","author":"Zalewski","year":"2019","journal-title":"Front. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zalewski, D.P., Ruszel, K.P., St\u0119pniewski, A., Ga\u0142kowski, D., Bogucki, J., Komsta, \u0141., Ko\u0142odziej, P., Chmiel, P., Zubilewicz, T., and Feldo, M. (2020). Dysregulation of MicroRNA Modulatory Network in Abdominal Aortic Aneurysm. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061974"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chen, H., and Boutros, P.C. (2011). VennDiagram: A Package for the Generation of Highly-Customizable Venn and Euler Diagrams in R. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-35"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J.-C., and M\u00fcller, M. (2011). PROC: An Open-Source Package for R and S+ to Analyze and Compare ROC Curves. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-77"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"MiRNet 2.0: Network-Based Visual Analytics for MiRNA Functional Analysis and Systems Biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zalewski, D.P., Ruszel, K.P., St\u0119pniewski, A., Ga\u0142kowski, D., Bogucki, J., Ko\u0142odziej, P., Szyma\u0144ska, J., P\u0142achno, B.J., Zubilewicz, T., and Feldo, M. (2021). Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063200"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"104339","DOI":"10.1016\/j.mvr.2022.104339","article-title":"Angiogenesis in Diabetic Mouse Model with Critical Limb Ischemia; Cell and Gene Therapy","volume":"141","author":"Nammian","year":"2022","journal-title":"Microvasc. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/s41598-022-04770-6","article-title":"MiR-548j-5p Regulates Angiogenesis in Peripheral Artery Disease","volume":"12","author":"Lee","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lamin, V., Verry, J., Eigner-Bybee, I., Fuqua, J.D., Wong, T., Lira, V.A., and Dokun, A.O. (2022). Modulation of MiR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010429"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"106906","DOI":"10.1016\/j.vph.2021.106906","article-title":"The Impact of Proangiogenic MicroRNA Modulation on Blood Flow Recovery Following Hind Limb Ischemia. A Systematic Review and Meta-Analysis of Animal Studies","volume":"141","author":"Theofilis","year":"2021","journal-title":"Vascul. Pharmacol."},{"key":"ref_53","first-page":"e9935671","article-title":"Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment","volume":"2021","author":"Wang","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"733985","DOI":"10.3389\/fcvm.2021.733985","article-title":"Mechanisms of Action of MiRNAs and LncRNAs in Extracellular Vesicle in Atherosclerosis","volume":"8","author":"Xu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"106901","DOI":"10.1016\/j.vph.2021.106901","article-title":"Potency of MiR-144-3p in Promoting Abdominal Aortic Aneurysm Progression in Mice Correlates with Apoptosis of Smooth Muscle Cells","volume":"142","author":"Yang","year":"2022","journal-title":"Vascul. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"119092","DOI":"10.1016\/j.lfs.2021.119092","article-title":"MicroRNA-23b Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching via FoxO4 Suppression","volume":"288","author":"Si","year":"2022","journal-title":"Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/FJC.0000000000000915","article-title":"Inhibition of MiR-188-5p Suppresses Progression of Experimental Abdominal Aortic Aneurysms","volume":"77","author":"Huang","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3892\/mmr.2021.12266","article-title":"MicroRNA-199a-5p Regulates FOXC2 to Control Human Vascular Smooth Muscle Cell Phenotypic Switch","volume":"24","author":"Cao","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jid.2019.07.694","article-title":"MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4","volume":"140","author":"Wu","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kansakar, U., Varzideh, F., Mone, P., Jankauskas, S.S., and Santulli, G. (2022). Functional Role of MicroRNAs in Regulating Cardiomyocyte Death. Cells, 11.","DOI":"10.3390\/cells11060983"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1038\/srep12276","article-title":"MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"116664","DOI":"10.1016\/j.lfs.2019.116664","article-title":"MicroRNA-99a-5p Alleviates Atherosclerosis via Regulating Homeobox A1","volume":"232","author":"Han","year":"2019","journal-title":"Life Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.prp.2019.02.002","article-title":"Expression Level and Prospective Mechanism of MiRNA-99a-3p in Head and Neck Squamous Cell Carcinoma Based on MiRNA-Chip and MiRNA-Sequencing Data in 1, 167 Cases","volume":"215","author":"Wei","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3892\/ijo.2017.3965","article-title":"MiR-196a-5p Modulates Gastric Cancer Stem Cell Characteristics by Targeting Smad4","volume":"50","author":"Pan","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Xin, H., Wang, C., and Liu, Z. (2019). MiR-196a-5p Promotes Metastasis of Colorectal Cancer via Targeting I\u03baB\u03b1. BMC Cancer, 19.","DOI":"10.1186\/s12885-018-5245-1"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.21037\/tlcr-20-1255","article-title":"Tumor-Associated Macrophages Secret Exosomal MiR-155 and MiR-196a-5p to Promote Metastasis of Non-Small-Cell Lung Cancer","volume":"10","author":"Li","year":"2021","journal-title":"Transl Lung Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BST0370217","article-title":"A Complex Interplay between Akt, TSC2 and the Two MTOR Complexes","volume":"37","author":"Huang","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.2006.108324","article-title":"AMPK and Cell Proliferation\u2014AMPK as a Therapeutic Target for Atherosclerosis and Cancer","volume":"574","author":"Motoshima","year":"2006","journal-title":"J. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"25880","DOI":"10.1074\/jbc.C110.109421","article-title":"The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-Dependent Vascular Inflammation and Atherogenesis","volume":"285","author":"Jin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coemr.2020.07.011","article-title":"Subcellular Hot Spots of GPCR Signaling Promote Vascular Inflammation","volume":"16","author":"Birch","year":"2021","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.18632\/oncotarget.24149","article-title":"EIF3C-Enhanced Exosome Secretion Promotes Angiogenesis and Tumorigenesis of Human Hepatocellular Carcinoma","volume":"9","author":"Lee","year":"2018","journal-title":"Oncotarget"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/cas.13209","article-title":"Transcriptomic Analyses of RNA-Binding Proteins Reveal EIF3c Promotes Cell Proliferation in Hepatocellular Carcinoma","volume":"108","author":"Li","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.3892\/mmr.2020.11538","article-title":"MiR-124-3p Regulates Angiogenesis in Peripheral Arterial Disease by Targeting STAT3","volume":"22","author":"Shi","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.arr.2018.02.002","article-title":"GIT2\u2014A Keystone in Ageing and Age-Related Disease","volume":"43","author":"Boddaert","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.7150\/thno.34463","article-title":"Long Noncoding RNA GAS5 Induces Abdominal Aortic Aneurysm Formation by Promoting Smooth Muscle Apoptosis","volume":"9","author":"He","year":"2019","journal-title":"Theranostics"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/12\/3470\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:33:13Z","timestamp":1760139193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/12\/3470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,16]]},"references-count":75,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["jcm11123470"],"URL":"https:\/\/doi.org\/10.3390\/jcm11123470","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,16]]}}}