{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:53:25Z","timestamp":1784159605171,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to evaluate whether the therapeutic switch from a formulation of Bimatoprost 0.1 mg\/mL with benzalkonium chloride (BAK) or Bimatoprost 0.3 mg\/mL preservative-free to a formulation of Bimatoprost 0.1 mg\/mL preservative-free could improve eye surface conditions in patients with glaucoma; intraocular pressure (IOP) was also evaluated. All patients meeting the inclusion criteria were eligible for the therapeutic switch to Bimatoprost 0.1 mg\/mL preservative-free. At each check visit, enrolled patients underwent a break-up time (BUT) test, an ocular surface disease index (OSDI) test, and a three-point tonometric curve. A total of 40 patients were enrolled (23 were in therapy with Bimatoprost 0.1 mg\/mL with BAK and 17 with Bimatoprost 0.3 mg\/mL preservative-free). Significant differences of OSDI and BUT between Bimatoprost 0.1 mg\/mL with BAK at baseline vs. Bimatoprost 0.1 mg\/mL preservative-free at 14 and 28 days (p &lt; 0.0001 and p = 0.0003, respectively) were recorded. Similarly, significant differences of OSDI and BUT between Bimatoprost 0.3 mg\/mL preservative-free at baseline vs. Bimatoprost 0.1 mg\/mL preservative-free at 14 and 28 days (p &lt; 0.0001 for both) were found. Bimatoprost 0.1 mg\/mL preservative-free has a better tolerability profile associated with non-therapeutical inferiority in the control of IOP compared to the other Bimatoprost formulations.<\/jats:p>","DOI":"10.3390\/jcm11123518","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T10:14:52Z","timestamp":1655633692000},"page":"3518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ocular Tolerability of Bimatoprost 0.1 mg\/mL Preservative-Free versus Bimatoprost 0.1 mg\/mL with Benzalkonium Chloride or Bimatoprost 0.3 mg\/mL Preservative-Free in Patients with Primary Open-Angle Glaucoma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-0200","authenticated-orcid":false,"given":"Mariaelena","family":"Filippelli","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Sciences, \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-9171","authenticated-orcid":false,"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, University of Rome \u201cSapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ciampa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-5775","authenticated-orcid":false,"given":"Gaetano","family":"Fioretto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Camillo Hospital, 00152 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Franco","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-8874","authenticated-orcid":false,"given":"Roberto","family":"dell\u2019Omo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences, \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8477-6188","authenticated-orcid":false,"given":"Ciro","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences, \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"},{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,19]]},"reference":[{"key":"ref_1","first-page":"668","article-title":"Glaucoma","volume":"93","author":"Gupta","year":"2016","journal-title":"Am. Fam. 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