{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:34:53Z","timestamp":1785764093539,"version":"3.56.0"},"reference-count":49,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["630-72\/2019-1"],"award-info":[{"award-number":["630-72\/2019-1"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["J3-9292"],"award-info":[{"award-number":["J3-9292"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["J3-9284"],"award-info":[{"award-number":["J3-9284"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["J3-3076"],"award-info":[{"award-number":["J3-3076"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["P5-0147"],"award-info":[{"award-number":["P5-0147"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["V5-2101"],"award-info":[{"award-number":["V5-2101"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Resistance exercise (RE) remains underused in cardiac rehabilitation; therefore, there is insufficient evidence on safety, feasibility, and hemodynamic adaptations to high-load (HL) and low-load (LL) RE in patients with coronary artery disease (CAD). This study aimed to compare the safety, feasibility of HL-RE and LL-RE when combined with aerobic exercise (AE), and hemodynamic adaptations to HL and LL resistance exercise following the intervention. Seventy-nine patients with CAD were randomized either to HL-RE (70\u201380% of one-repetition maximum [1-RM]) and AE, LL-RE (35\u201340% of 1-RM) and AE or solely AE (50\u201380% of maximal power output) as a standard care, and 59 patients completed this study. We assessed safety and feasibility of HL-RE and LL-RE and we measured 1-RM on leg extension machine and hemodynamic response during HL- and LL-RE at baseline and post-training. The training intervention was safe, well tolerated, and completed without any adverse events. Adherence to RE protocols was excellent (100%). LL-RE was better tolerated than HL-RE, especially from the third to the final mesocycle of this study (Borgs\u2019 0\u201310 scale difference: 1\u20132 points; p = 0.001\u20130.048). Improvement in 1-RM was greater following HL-RE (+31%, p &lt; 0.001) and LL-RE (+23%, p &lt; 0.001) compared with AE. Participation in HL-RE and LL-RE resulted in a decreased rating of perceived exertion during post-training HL- and LL-RE, but in the absence of post-training hemodynamic adaptations. The implementation of HL-RE or LL-RE combined with AE was safe, well tolerated and can be applied in the early phase of cardiac rehabilitation for patients with stable CAD.<\/jats:p>","DOI":"10.3390\/jcm11133567","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T21:55:19Z","timestamp":1655848519000},"page":"3567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High-Load and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: Feasibility and Safety of a Randomized Controlled Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-7928","authenticated-orcid":false,"given":"Tim","family":"Kambic","sequence":"first","affiliation":[{"name":"Cardiac Rehabilitation Unit, Department of Research and Education, General Hospital Murska Sobota, Ulica dr. Vrbnjaka 6, Raki\u010dan, 9000 Murska Sobota, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-3735","authenticated-orcid":false,"given":"Nejc","family":"\u0160arabon","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Primorska, Polje 42, 6310 Izola, Slovenia"},{"name":"InnoRenew CoE, Human Health Department, Livade 6, 6310 Izola, Slovenia"},{"name":"S2P, Science to Practice, Ltd., Laboratory for Motor Control and Motor Behavior, Tehnolo\u0161ki Park 19, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6918-9994","authenticated-orcid":false,"given":"Vedran","family":"Had\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Sport, University of Ljubljana, Gortanova Ulica 22, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-4098","authenticated-orcid":false,"given":"Mitja","family":"Lainscak","sequence":"additional","affiliation":[{"name":"Division of Cardiology, General Hospital Murska Sobota, Ulica dr. Vrbnjaka 6, Raki\u010dan, 9000 Murska Sobota, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/2047487320913379","article-title":"Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology","volume":"28","author":"Ambrosetti","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/eurjpc\/zwab007","article-title":"Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: Why and how: A position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology","volume":"29","author":"Hansen","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1161\/CIRCULATIONAHA.106.180945","article-title":"Core components of cardiac rehabilitation\/secondary prevention programs: 2007 update: A scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation","volume":"115","author":"Balady","year":"2007","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1177\/2047487316657669","article-title":"A review of guidelines for cardiac rehabilitation exercise programmes: Is there an international consensus?","volume":"23","author":"Price","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ijcard.2016.12.076","article-title":"Implementing resistance training in the rehabilitation of coronary heart disease: A systematic review and meta-analysis","volume":"230","author":"Xanthos","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1177\/2047487317713329","article-title":"The effect of progressive resistance training on aerobic fitness and strength in adults with coronary heart disease: A systematic review and meta-analysis of randomised controlled trials","volume":"24","author":"Hollings","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/01.hjr.0000137692.36013.27","article-title":"Recommendations for resistance exercise in cardiac rehabilitation. Recommendations of the German Federation for Cardiovascular Prevention and Rehabilitation","volume":"11","author":"Meister","year":"2004","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/jappl.1985.58.3.785","article-title":"Arterial blood pressure response to heavy resistance exercise","volume":"58","author":"MacDougall","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1519\/JSC.0b013e31827de07d","article-title":"The Valsalva Maneuver: Its Effect on Intra-abdominal Pressure and Safety Issues During Resistance Exercise","volume":"27","author":"Hackett","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1177\/2047487319850718","article-title":"The association of resistance training with mortality: A systematic review and meta-analysis","volume":"26","author":"Saeidifard","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"American College of Sports Medicine (2009). Progression Models in Resistance Training for Healthy Adults. Med. Sci. Sport Exerc., 41, 687\u2013708. Available online: https:\/\/journals.lww.com\/acsm-msse\/Fulltext\/2009\/03000\/Progression_Models_in_Resistance_Training_for.26.aspx.","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","article-title":"Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association","volume":"33","author":"Fragala","year":"2019","journal-title":"J. Strength Cond. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1519\/JSC.0000000000002200","article-title":"Strength and hypertrophy adaptations between low- versus high-load resistance training","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.apmr.2013.02.022","article-title":"Systematic Review of High-Intensity Progressive Resistance Strength Training of the Lower Limb Compared with Other Intensities of Strength Training in Older Adults","volume":"94","author":"Raymond","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1177\/0269215511423408","article-title":"Resistance exercise in cardiac rehabilitation","volume":"25","author":"Wise","year":"2011","journal-title":"Clin. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1249\/MSS.0000000000000811","article-title":"Hemodynamic Responses to Resistance Exercise in Patients with Coronary Artery Disease","volume":"48","author":"Mirtaheri","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/204748730501200103","article-title":"The Effect of Different Intensity Modalities of Resistance Training on Beat-to-Beat Blood Pressure in Cardiac Patients","volume":"12","author":"LaMotte","year":"2005","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/HJR.0b013e328332efdd","article-title":"Acute cardiovascular response to resistance training during cardiac rehabilitation: Effect of repetition speed and rest periods","volume":"17","author":"LaMotte","year":"2009","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kambic, T., Had\u017ei\u0107, V., and Lainscak, M. (2021). Hemodynamic Response to High- and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: A Randomized, Crossover Clinical Trial. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18083905"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1177\/2047487319847003","article-title":"Dynamic strength training intensity in cardiovascular rehabilitation: Is it time to reconsider clinical practice? A systematic review","volume":"26","author":"Hansen","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e051325","DOI":"10.1136\/bmjopen-2021-051325","article-title":"Effects of high-load and low-load resistance training in patients with coronary artery disease: Rationale and design of a randomised controlled clinical trial","volume":"11","author":"Kambic","year":"2021","journal-title":"BMJ Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCULATIONAHA.107.185214","article-title":"Resistance exercise in individuals with and without cardiovascular disease: 2007 update: A scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism","volume":"116","author":"Williams","year":"2007","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/HCR.0b013e3181fc0970","article-title":"Characteristics of Patients Entering Cardiac Rehabilitation in the United Kingdom 1993-2006: IMPLICATIONS FOR THE FUTURE","volume":"31","author":"Evans","year":"2011","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Schwaab, B., Bjarnason-Wehrens, B., Meng, K., Albus, C., Salzwedel, A., Schmid, J.-P., Benzer, W., Metz, M., Jensen, K., and Rauch, B. (2021). Cardiac Rehabilitation in German Speaking Countries of Europe\u2014Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH\u2014Part 2. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102192"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/j.jelekin.2007.08.009","article-title":"Effects of exercise training modality on skeletal muscle fatigue in men with coronary heart disease","volume":"19","author":"Gayda","year":"2009","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1249\/MSS.0b013e318177eb7f","article-title":"Aerobic and resistance training in coronary disease: Single versus multiple sets","volume":"40","author":"Marzolini","year":"2008","journal-title":"Med. Sci. Sport Exerc."},{"key":"ref_28","unstructured":"Baechle, T.R., and Earle, R.W. (2008). Resistance Training. Essentials of Strength and Conditioning Researchq, Human Kinetics. [3rd ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/07303084.1993.10606684","article-title":"Strength Testing\u2014Predicting a One-Rep Max from Reps-to-Fatigue","volume":"64","author":"Brzycki","year":"1993","journal-title":"J. Phys. Educ. Recreat. Danc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e009305","DOI":"10.1161\/JAHA.118.009305","article-title":"High-Intensity Interval Training for Patients with Cardiovascular Disease\u2014Is It Safe? A Systematic Review","volume":"7","author":"Wewege","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"659","DOI":"10.7326\/0003-4819-143-9-200511010-00010","article-title":"Meta-Analysis: Secondary Prevention Programs for Patients with Coronary Artery Disease","volume":"143","author":"Clark","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1177\/2047487312462824","article-title":"Lifestyle modification programmes for patients with coronary heart disease: A systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Janssen","year":"2012","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijcard.2016.08.120","article-title":"Participation and adherence to cardiac rehabilitation programs. A systematic review","volume":"223","author":"Raposeiras","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijcard.2016.11.059","article-title":"Exercise-based cardiac rehabilitation in twelve European countries results of the European cardiac rehabilitation registry","volume":"228","author":"Benzer","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bjsports-2013-092576","article-title":"High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: A systematic review and meta-analysis","volume":"48","author":"Weston","year":"2014","journal-title":"Br. J. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1046\/j.1532-5415.2002.50267.x","article-title":"Resistance Exercise and Physical Performance in Adults Aged 60 to 83","volume":"50","author":"Vincent","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_38","first-page":"833","article-title":"The Effect of Resistance-Training Intensity on Strength-Gain Response in the Older Adult","volume":"18","author":"Harris","year":"2004","journal-title":"J. Strength Cond. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00008483-199901000-00001","article-title":"High-Intensity Strength Training of Patients Enrolled in an Outpatient Cardiac Rehabilitation Program","volume":"19","author":"Beniamini","year":"1999","journal-title":"J. Cardiopulm. Rehabil."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2340\/16501977-0122","article-title":"Effect of aerobic vs. combined aerobic-strength training on 1-year, post-cardiac rehabilitation outcomes in women after a cardiac event","volume":"39","author":"Arthur","year":"2007","journal-title":"Acta Derm. Venereol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kambic, T., \u0160arabon, N., Had\u017ei\u0107, V., and Lainscak, M. (2022). Effects of high- and low-load resistance training in patients with coronary artery disease: A randomized controlled clinical trial. Eur. J. Prev. Cardiol.","DOI":"10.3390\/jcm11133567"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/brain\/awg079","article-title":"Motor learning elicited by voluntary drive","volume":"126","author":"Lotze","year":"2003","journal-title":"Brain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.apmr.2011.04.021","article-title":"Resistance Training Dose Response in Combined Endurance-Resistance Training in Patients With Cardiovascular Disease: A Randomized Trial","volume":"92","author":"Berent","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jsams.2014.09.013","article-title":"Effects of resistance training combined with moderate-intensity endurance or low-volume high-intensity interval exercise on cardiovascular risk factors in patients with coronary artery disease","volume":"18","author":"Currie","year":"2015","journal-title":"J. Sci. Med. Sport"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/02701367.2018.1519385","article-title":"Effects of Resistance Training on Vascular and Hemodynamic Responses in Patients with Coronary Artery Disease","volume":"89","author":"Grafe","year":"2018","journal-title":"Res. Q. Exerc. Sport"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0002-9149(89)90833-3","article-title":"Effects of high resistance training in coronary artery disease","volume":"64","author":"Ghilarducci","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1519\/SSC.0000000000000373","article-title":"Relationship Between the Rating of Perceived Exertion Scale and the Load Intensity of Resistance Training","volume":"40","author":"Morishita","year":"2018","journal-title":"Strength Cond. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1055\/s-0043-115737","article-title":"Cardiovascular Responses to Different Resistance Exercise Protocols in Elderly","volume":"38","author":"Sardeli","year":"2017","journal-title":"Int. J. Sports Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1519\/JSC.0000000000001200","article-title":"Application of Session Rating of Perceived Exertion Among Different Models of Resistance Training in Older Adults","volume":"29","author":"Conlon","year":"2015","journal-title":"J. Strength Cond. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3567\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:36:22Z","timestamp":1760139382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":49,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["jcm11133567"],"URL":"https:\/\/doi.org\/10.3390\/jcm11133567","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}