{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:43:23Z","timestamp":1781649803007,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FACINGLCOVID-CM project","award":["Y2020\/BIO-6600"],"award-info":[{"award-number":["Y2020\/BIO-6600"]}]},{"name":"METAINFLAMACION","award":["Y2020\/BIO-6600"],"award-info":[{"award-number":["Y2020\/BIO-6600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>COVID-19 has overloaded health system worldwide; thus, it demanded a triage method for an efficient and early discrimination of patients with COVID-19. The objective of this research was to perform a model based on commonly requested hematological variables for an early featuring of patients with COVID-19 form other viral pneumonia. This investigation enrolled 951 patients (mean of age 68 and 56% of male) who underwent a PCR test for respiratory viruses between January 2019 and January 2020, and those who underwent a PCR test for detection of SARS-CoV-2 between February 2020 and October 2020. A comparative analysis of the population according to PCR tests and logistic regression model was performed. A total of 10 variables were found for the characterization of COVID-19: age, sex, anemia, immunosuppression, C-reactive protein, chronic obstructive pulmonary disease, cardiorespiratory disease, metastasis, leukocytes and monocytes. The ROC curve revealed a sensitivity and specificity of 75%. A deep analysis showed low levels of leukocytes in COVID-19-positive patients, which could be used as a primary outcome of COVID-19 detection. In conclusion, this investigation found that commonly requested laboratory variables are able to help physicians to distinguish COVID-19 and perform a quick stratification of patients into different prognostic categories.<\/jats:p>","DOI":"10.3390\/jcm11133578","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T21:55:19Z","timestamp":1655848519000},"page":"3578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hematological- and Immunological-Related Biomarkers to Characterize Patients with COVID-19 from Other Viral Respiratory Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Rafael","family":"Su\u00e1rez-Del-Villar-Carrero","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-7349","authenticated-orcid":false,"given":"Diego","family":"Martinez-Urbistondo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cuevas-Sierra","sequence":"additional","affiliation":[{"name":"IMDEA-Food Institute (Madrid Institute for Advances Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iciar","family":"Iba\u00f1ez-Sustacha","sequence":"additional","affiliation":[{"name":"School of Medicine, San Pablo CEU University, 28925 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Candela-Fernandez","sequence":"additional","affiliation":[{"name":"School of Medicine, San Pablo CEU University, 28925 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dominguez-Calvo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-1555","authenticated-orcid":false,"given":"Omar","family":"Ramos-Lopez","sequence":"additional","affiliation":[{"name":"Medicine and Psychology School, Autonomous University of Baja California, Tijuana 22390, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-4304","authenticated-orcid":false,"given":"Juan Antonio","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain"},{"name":"Department of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-3486","authenticated-orcid":false,"given":"Guillermo","family":"Reglero","sequence":"additional","affiliation":[{"name":"IMDEA-Food Institute (Madrid Institute for Advances Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Villares-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alfredo","family":"Martinez","sequence":"additional","affiliation":[{"name":"IMDEA-Food Institute (Madrid Institute for Advances Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: Immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. 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