{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:42:44Z","timestamp":1790185364269,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019000","name":"Medical Affairs Bureau Ministry of National Defense","doi-asserted-by":"publisher","award":["MND-MAB-D-11115"],"award-info":[{"award-number":["MND-MAB-D-11115"]}],"id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019000","name":"Medical Affairs Bureau Ministry of National Defense","doi-asserted-by":"publisher","award":["HAFGH-D-111003"],"award-info":[{"award-number":["HAFGH-D-111003"]}],"id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hualien Armed Forces General Hospital","award":["MND-MAB-D-11115"],"award-info":[{"award-number":["MND-MAB-D-11115"]}]},{"name":"Hualien Armed Forces General Hospital","award":["HAFGH-D-111003"],"award-info":[{"award-number":["HAFGH-D-111003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The relationship of cardiorespiratory fitness (CRF) with subclinical atherosclerosis affected by the body adiposity has been observed in children, whereas this relationship remains unclear in young adults. Methods and Results: A total of 1520 military recruits, aged 18\u201340 years, were included in Taiwan in 2018\u20132020. All subjects underwent detailed physical and blood laboratory examinations. CRF was evaluated by time for a 3000 m run, and subclinical atherosclerosis was evaluated by intima\u2013media thickness of the bulb of the left common carotid artery (cIMT) utilizing high-resolution ultrasonography. Multivariable linear regression analysis with adjustments for age, sex, cigarette smoking, alcohol intake, systolic and diastolic blood pressure, high- and low-density lipoprotein cholesterols, fasting glucose, waist circumference, serum uric acid and serum triglycerides were utilized to determine the correlation between CRF and cIMT. CRF was independently correlated with cIMT (standardized \u03b2: 0.11, p &lt; 0.001). Of the cardiometabolic risk markers, serum triglycerides were the only independent risk marker of cIMT (standardized \u03b2: 0.063, p = 0.03). In addition, the association of CRF with cIMT did not differ between those with a body mass index (BMI) \u2265 25 kg\/m2 and those with BMI &lt; 25 kg\/m2 (standardized \u03b2: 0.103 and 0.117; p = 0.01 and 0.005, respectively). Conclusions: In physically active young men and women, there was an inverse association of cIMT with CRF, which was observed in both overweight\/mild obesity and normal-weight individuals, highlighting the importance of endurance capacity on reducing risk of early atherosclerosis and implying that the moderation effect of body adiposity might not be present in this population.<\/jats:p>","DOI":"10.3390\/jcm11133653","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T09:00:13Z","timestamp":1656234013000},"page":"3653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cardiorespiratory Fitness and Carotid Intima\u2013Media Thickness in Physically Active Young Adults: CHIEF Atherosclerosis Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-1056","authenticated-orcid":false,"given":"Gen-Min","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien 970, Taiwan"},{"name":"Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-9757","authenticated-orcid":false,"given":"Pang-Yen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien 970, Taiwan"},{"name":"Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-1545","authenticated-orcid":false,"given":"Kun-Zhe","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien 970, Taiwan"},{"name":"Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"},{"name":"Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien 970, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"},{"name":"John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA 70121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Lavie","sequence":"additional","affiliation":[{"name":"John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA 70121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM199806043382302","article-title":"Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. 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