{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:42:28Z","timestamp":1779028948389,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by Andr\u00e9 et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 \u00b1 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28\u20130.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32\u20130.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35\u20133.40]; p = 0.001 and HR 1.78; 95% CI [1.07\u20132.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse.<\/jats:p>","DOI":"10.3390\/jcm11133669","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T09:00:13Z","timestamp":1656234013000},"page":"3669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years\u2019 Evolution Data on a 71-Patient Series"],"prefix":"10.3390","volume":"11","author":[{"given":"Ludovic","family":"Trefond","sequence":"first","affiliation":[{"name":"M\u00e9decine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, France"},{"name":"M2iSH, UMR 1071 Inserm, INRA USC 2018, University of Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Frances","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, AP-HP, Service de Dermatologie et Allergologie, H\u00f4pital Tenon, Sorbonne Universit\u00e9, 75252 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Costedoat-Chalumeau","sequence":"additional","affiliation":[{"name":"APHP, Service de M\u00e9decine Interne, Centre de R\u00e9f\u00e9rence des Maladies Auto-Immunes Syst\u00e9miques Rares d\u2019Ile de France, H\u00f4pital Cochin, 27 rue du Faubourg St-Jacques, CEDEX 14, 75679 Paris, France"},{"name":"INSERM U 1153, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-2087","authenticated-orcid":false,"given":"Jean-Charles","family":"Piette","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, AP-HP Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Haroche","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Groupement Hospitalier Piti\u00e9\u2013Salp\u00eatri\u00e8re (GHPS), French National Reference Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de M\u00e9decine Interne 2, Institut E3M, Sorbonne Universit\u00e9, 75252 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Sailler","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, CHU de Toulouse\u2014H\u00f4pital Purpan, 31300 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souad","family":"Assaad","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Viallard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Service de M\u00e9decine Interne et Maladies Infectieuses, Universit\u00e9 de BORDEAUX, 5 Avenue de Magellan, 33604 Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Jego","sequence":"additional","affiliation":[{"name":"Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail)-UMR_S 1085, Inserm, EHESP, University of Rennes, 35000 Rennes, France"},{"name":"Department of Internal Medicine, Rennes University Hospital, 35203 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Hot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Connault","sequence":"additional","affiliation":[{"name":"Department of Internal and Vascular Medicine, CHU de Nantes, 44000 Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Galempoix","sequence":"additional","affiliation":[{"name":"M\u00e9decine Infectieuse, CHInA, 08000 Charleville-M\u00e9zi\u00e8res, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Aslangul","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Louis-Mourier, Assistance Publique-H\u00f4pitaux de Paris, 92701 Colombes, France"},{"name":"UPD5, Universit\u00e9 Paris-Descartes, rue de l\u2019\u00c9cole-de-M\u00e9decine, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Limal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne, H\u00f4pital Henri Mondor, APHP Universit\u00e9 Paris-Est Cr\u00e9teil, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Bordeaux University Hospital, Saint Andr\u00e9 Hospital, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, CHU de Toulouse, 31000 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-4310","authenticated-orcid":false,"given":"Olivier","family":"Chosidow","sequence":"additional","affiliation":[{"name":"Department of Dermatology, APHP, H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France"},{"name":"Research Group Dynamic, EA7380, Facult\u00e9 de Sant\u00e9 de Cr\u00e9teil, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, USC ANSES, Universit\u00e9 Paris-Est Cr\u00e9teil, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Deligny","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU de Fort de France, 97200 Fort de France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-3170","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Lifermann","sequence":"additional","affiliation":[{"name":"Medecine Interne, Centre Hospitalier de Dax, 40107 Dax, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-5804","authenticated-orcid":false,"given":"Alexandre Thibault Jacques","family":"Maria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Eloi Hospital, Montpellier University, 34000 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-7161","authenticated-orcid":false,"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biostatistics Unit (DRCI), University Hospital Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Aumaitre","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, France"},{"name":"M2iSH, UMR 1071 Inserm, INRA USC 2018, University of Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, CHU Gabriel Montpied, 63000 Clermont-Ferrand, France"},{"name":"M2iSH, UMR 1071 Inserm, INRA USC 2018, University of Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the French Study Group on Aseptic Abscesses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"ref_1","first-page":"1086","article-title":"Sterile epidural and bilateral psoas abscesses in a patient with Crohn\u2019s disease","volume":"89","author":"Lamport","year":"1994","journal-title":"Am. 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Dermatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3669\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:40:10Z","timestamp":1760139610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":32,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["jcm11133669"],"URL":"https:\/\/doi.org\/10.3390\/jcm11133669","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]}}}