{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:08:40Z","timestamp":1762056520270,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"intramural grants from the D\u2019Or Institute of Research and Education","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]},{"name":"Brazilian Clinical Research Institute","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]},{"name":"FINEP","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]},{"name":"Serrapilheira Institute","award":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"],"award-info":[{"award-number":["E-26\/210.155\/2020","E-26\/203.169\/2017","E-26\/210.191\/2020","E-26\/210.253\/2020","310681\/2018-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4\/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications.<\/jats:p>","DOI":"10.3390\/jcm11133713","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T22:31:14Z","timestamp":1656369074000},"page":"3713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-7319","authenticated-orcid":false,"given":"Renata","family":"Moll-Bernardes","sequence":"first","affiliation":[{"name":"D\u2019Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4539-6825","authenticated-orcid":false,"given":"S\u00e9rgio C.","family":"Fortier","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil"},{"name":"Pathological Anatomy Laboratory, Rede D\u2019Or S\u00e3o Luiz, S\u00e3o Paulo 04321-120, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a S.","family":"Sousa","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil"},{"name":"Evandro Chagas National Institute of Infectious 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