{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:29:15Z","timestamp":1783542555380,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients \u2265 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were \u226580 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29\u20130.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22\u20130.61) (p &lt; 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19.<\/jats:p>","DOI":"10.3390\/jcm11133769","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"3769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Remdesivir in Very Old Patients (\u226580 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-9867","authenticated-orcid":false,"given":"Jose-Manuel","family":"Ramos-Rincon","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Miguel Hernandez University of Elche, Ctra N332 s\/n, 03550 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-076X","authenticated-orcid":false,"given":"Mar\u00eda-Dolores","family":"L\u00f3pez-Carmona","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Instituto de Investigacion Biomedica de M\u00e1laga (IBIMA), Regional University Hospital of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Department of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-233X","authenticated-orcid":false,"given":"Lidia","family":"Cobos-Palacios","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Instituto de Investigacion Biomedica de M\u00e1laga (IBIMA), Regional University Hospital of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Department of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-8536","authenticated-orcid":false,"given":"Almudena","family":"L\u00f3pez-Sampalo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Instituto de Investigacion Biomedica de M\u00e1laga (IBIMA), Regional University Hospital of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Department of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-1374","authenticated-orcid":false,"given":"Manuel","family":"Rubio-Rivas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Bellvitge University Hospital, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-8682","authenticated-orcid":false,"given":"Mar\u00eda-Dolores","family":"Mart\u00edn-Escalante","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Costa del Sol Hospital, 29603 Marbella, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-1119","authenticated-orcid":false,"given":"Santiago","family":"de-Cossio-Tejido","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Doce de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Luisa","family":"Taboada-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Cabue\u00f1es University Hospital, 33394 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mui\u00f1o-Miguez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Gregorio Mara\u00f1\u00f3n General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Areses-Manrique","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Santa Marina Hospital, 48004 Bilbo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-9288","authenticated-orcid":false,"given":"Carmen","family":"Martinez-Cilleros","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, HLA Moncloa University Hospital, 28008 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota","family":"Tu\u00f1\u00f3n-de-Almeida","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Zamora Hospital Complex, 49022 Zamora, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Abella-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Nuestra Se\u00f1ora Candelaria University Hospital, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel-Lu\u00eds","family":"Mart\u00ednez-Gonzalez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Leon University Hospital Complex, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis-Felipe","family":"D\u00edez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Torrec\u00e1rdenas University Hospital, 04009 Almer\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-7540","authenticated-orcid":false,"given":"Carlos-Jorge","family":"Ripper","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Insular University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-456X","authenticated-orcid":false,"given":"Victor","family":"Asensi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Central Asturias, University Hospital, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Martinez-Pascual","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Francesc de Borja Hospital, 46702 Gandia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-4398","authenticated-orcid":false,"given":"Pablo","family":"Guisado-Vasco","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Quironsalud A Coru\u00f1a Hospital, 15009 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-8288","authenticated-orcid":false,"given":"Carlos","family":"Lumbreras-Bermejo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Doce de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-8197","authenticated-orcid":false,"given":"Ricardo","family":"G\u00f3mez-Huelgas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Instituto de Investigacion Biomedica de M\u00e1laga (IBIMA), Regional University Hospital of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Department of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"CIBER Fisiopatologia de la Obesidad y la Nutricion, Carlos III Health Institute, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SEMI-COVID-19 Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/phar.2429","article-title":"Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19","volume":"40","author":"Jorgensen","year":"2020","journal-title":"Pharmacotherapy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(20)31022-9","article-title":"Remdesivir in adults with severe COVID-19: A randomised, double-blind, 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