{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:33:55Z","timestamp":1789871635071,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Research and Scientific and Technological Development of Maranh\u00e3o\u2014FAPEMA, Brazil","award":["PAEDT-01918\/15"],"award-info":[{"award-number":["PAEDT-01918\/15"]}]},{"name":"Foundation for Research and Scientific and Technological Development of Maranh\u00e3o\u2014FAPEMA, Brazil","award":["POS-GRAD 02355\/21"],"award-info":[{"award-number":["POS-GRAD 02355\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Aim: The development of postoperative pain following root canal instrumentation may impair patient\u2019s comfort and undermine their trust in the dentist. This study assessed the effect of root canal instrumentation techniques (rotary (PTN; ProTaper Next\u00ae) and reciprocating (R; Reciproc\u00ae)) on the postoperative pain intensity (primary outcome) and tenderness on biting (secondary outcome) of patients\u2019 asymptomatic molars. Methodology: This study protocol was registered with ReBec-WHO (U1111-1182-2800). From a pool of 112 patients evaluated for eligibility (healthy adults (\u226418 years old)), with a single asymptomatic molar (maxillary or mandibular) indicated for root canal treatment, diagnosed with asymptomatic irreversible pulpitis (including chronic hyperplastic pulpitis), 75 were randomly allocated in similar proportions to receive the intervention (two-appointment root canal therapy) in either the PTN or R group. The allocated procedures were performed using standardized protocols. Participants (blinded to the instrumentation technique) rated their pain intensity at 6, 12 and 24 h and from day 2 to day 7 following the root canal instrumentation appointment using a VAS and an NRS; the ibuprofen tablets taken and the presence of tenderness on biting were recorded. The instrumentation time was registered. Univariate and multivariate statistics measured the effect of independent variables on the outcomes. Results: From the 75 patients allocated, 8 patients (4 from each group) were lost; in total, 33 patients were analyzed in the PTN group and 34 in the R group. The frequencies of postoperative pain (p &gt; 0.05) and tenderness on biting (p &gt; 0.05) were similar between groups. The medication intake (mean of 1.31 tablets) and the time of instrumentation (approximately 11 min) were similar between groups. Conclusion: ProTaper Next and Reciproc\u00ae caused a slight risk of tenderness on biting and contributed to similar self-reported postoperative pain (low intensity) up to 7 days following root canal shaping.<\/jats:p>","DOI":"10.3390\/jcm11133816","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T01:40:36Z","timestamp":1656639636000},"page":"3816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Postoperative Pain Following Root Canal Instrumentation Using ProTaper Next or Reciproc in Asymptomatic Molars: A Randomized Controlled Single-Blind Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"given":"Patr\u00edcia Santos","family":"Oliveira","sequence":"first","affiliation":[{"name":"Postgraduate Program of Dentistry, CEUMA University, S\u00e3o Lu\u00eds 65065-470, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7116-1547","authenticated-orcid":false,"given":"Meire Coelho","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Dentistry, CEUMA University, S\u00e3o Lu\u00eds 65065-470, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Gomes Nascimento","family":"Paula","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Dentistry, CEUMA University, S\u00e3o Lu\u00eds 65065-470, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-4856","authenticated-orcid":false,"given":"Alessandro Dourado","family":"Loguercio","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-4103","authenticated-orcid":false,"given":"Renata","family":"Grazziotin-Soares","sequence":"additional","affiliation":[{"name":"College of Dentistry, University of Saskatchewan, Saskatoon, SK S7N5B2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-1339","authenticated-orcid":false,"given":"Gisele Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Federal University of Uberl\u00e2ndia (UFU), Uberl\u00e2ndia 38408-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Cristina Santos","family":"da Mata","sequence":"additional","affiliation":[{"name":"Private Practice, Da Mata Odontologia, S\u00e3o Paulo 04020-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-0331","authenticated-orcid":false,"given":"Jos\u00e9","family":"Bauer","sequence":"additional","affiliation":[{"name":"Dentistry Biomaterials Laboratory (Biomma), School of Dentistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-4081","authenticated-orcid":false,"given":"Ceci Nunes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Dentistry, CEUMA University, S\u00e3o Lu\u00eds 65065-470, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.joen.2010.04.012","article-title":"Postoperative pain after the application of two different irrigation devices in a prospective randomized clinical trial","volume":"36","author":"Gondim","year":"2010","journal-title":"J. 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