{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:32:21Z","timestamp":1772836341160,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III project","doi-asserted-by":"publisher","award":["PI17\/01717"],"award-info":[{"award-number":["PI17\/01717"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III project","doi-asserted-by":"publisher","award":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica y de Innovaci\u00f3n 2013\u20132016","award":["PI17\/01717"],"award-info":[{"award-number":["PI17\/01717"]}]},{"name":"Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica y de Innovaci\u00f3n 2013\u20132016","award":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"European Regional Development Fund \u201ca way to make Europe\u201d","award":["PI17\/01717"],"award-info":[{"award-number":["PI17\/01717"]}]},{"name":"European Regional Development Fund \u201ca way to make Europe\u201d","award":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PDI2020-114821RB-I00 MCIN\/AEI\/10.13039\/501100011033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants with NAFLD. We included participants diagnosed with NAFLD, both HIV-infected and HIV-uninfected. Fatty acid methyl esters were measured from plasma samples. Ratios ([product]\/[substrate]) were used to estimate desaturases and elongases activity. We used linear regression for adjusted analyses. We included 31 PLWH and 22 HIV-uninfected controls. We did not find differences in the sum of different types of FA or in FA with a greater presence of plasma. However, there were significant differences in the distribution of some FA, with higher concentrations of ALA, trans-palmitoleic, and behenic acids, and a lower concentration of lignoceric acid in PLWH. PLWH had lower C24:0\/C22:0 and C16:0\/C14:0 ratios, which estimates the activity of elongases ELOVL1 and ELOVL6. Both groups had similar fatty acid distribution, despite differences in traditional risk factors. PLWH had a lower proportion of specific ratios that estimate ELOVL1 and ELOVL6 activity, which had been previously described for other inflammatory conditions, such as psoriasis.<\/jats:p>","DOI":"10.3390\/jcm11133842","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T22:50:46Z","timestamp":1656888646000},"page":"3842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-3908","authenticated-orcid":false,"given":"Javier","family":"Mart\u00ednez-Sanz","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-7661","authenticated-orcid":false,"given":"Mar\u00eda Visitaci\u00f3n","family":"Calvo","sequence":"additional","affiliation":[{"name":"Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL, CSIC-UAM), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5447-3554","authenticated-orcid":false,"given":"Sergio","family":"Serrano-Villar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Montes","sequence":"additional","affiliation":[{"name":"HIV Unit\u2014Internal Medicine Service, Hospital Universitario la Paz\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-211X","authenticated-orcid":false,"given":"Rosa","family":"Mart\u00edn-Mateos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Metabolic Liver Disease Clinic, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Universidad de Alcal\u00e1, 28871 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-8112","authenticated-orcid":false,"given":"Diego","family":"Burgos-Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Metabolic Liver Disease Clinic, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"D\u00edaz-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Talavera-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-2471","authenticated-orcid":false,"given":"Marta","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, 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