{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:48:59Z","timestamp":1787788139925,"version":"build-2784847793"},"reference-count":69,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study analyzed the individual differences in hemodynamic time patterns and reactivity to cognitive and emotional tasks, and explored the diversity of psycho-physiological profiles that could be used for the personalized prediction of different diseases. An analysis of heart rate (HR)\u2014blood pressure (BP) relationship patterns across time using cross-correlations (CCs) during a logical-mathematical task and a task recalling negative emotions (rumination) was carried out in a laboratory setting on 45 participants. The results showed maximum HR\u2013BP CCs during the mathematical task significantly more positive than the maximum HR\u2013BP CCs during the rumination task. Furthermore, our results showed a large variety of hemodynamic reactivity profiles across the participants, even when carrying out the same tasks. The most frequent type showed positive HR\u2013BP CCs under cognitive activity, and several positive\u2013negative HR\u2013BP CCs cycles under negative emotional activity. In general terms, our results supported the main hypothesis. We observed some distinct time-based \u201ccoordination strategies\u201d in the reactivity of the autonomic nervous system under emotional vs. cognitive loading. Overall, large individual, as well as situational, specificities in hemodynamic reactivity time patterns were seen. The possible relationships between this variety of profiles and different psychosocial characteristics, and the potential for integrative predictive health within the provision of highly personalized medicine, are discussed.<\/jats:p>","DOI":"10.3390\/jcm11133869","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T11:15:05Z","timestamp":1656933305000},"page":"3869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diversity of Hemodynamic Reactive Profiles across Persons\u2014Psychosocial Implications for Personalized Medicine"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-4879","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Gandarillas","sequence":"first","affiliation":[{"name":"Department of Social, Work, and Differential Psychology, School of Psychology, Complutense University of Madrid, Campus de Somosagua, Ctra. de H\u00famera, s\/n, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-0723","authenticated-orcid":false,"given":"Nandu","family":"Goswami","sequence":"additional","affiliation":[{"name":"Physiology Division, Otto Loewi Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, 8036 Graz, Austria"},{"name":"Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Calhoun, D.A., and Oparil, S. (2004). Hypertension and Sympathetic Nervous System Activity. Primer on the Autonomic Nervous System, Academic Press.","DOI":"10.1016\/B978-012589762-4\/50064-5"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1590\/S0102-79722005000100009","article-title":"Estressores sociais da hipertens\u00e3o em comunidades carentes","volume":"18","author":"Gandarillas","year":"2005","journal-title":"Psicol. Reflex\u00e3o E Cr\u00edtica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12160-016-9851-3","article-title":"Hemodynamic Profiles of Functional and Dysfunctional Forms of Repetitive Thinking","volume":"51","author":"Ottaviani","year":"2016","journal-title":"Ann. Behav. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Walther, L.M., Von K\u00e4nel, R., Heimgartner, N., Zuccarella-Hackl, C., Ehlert, U., and Wirtz, P.H. (2021). Altered Cardiovascular Reactivity to and Recovery from Cold Face Test-Induced Parasympathetic Stimulation in Essential Hypertension. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122714"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pnpbp.2006.08.015","article-title":"Baroreflex mechanisms in major depression","volume":"31","author":"Davydov","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.psych.53.100901.135208","article-title":"Effects of Psychological and Social Factors on Organic Disease: A Critical Assessment of Research on Coronary Heart Disease","volume":"53","author":"Krantz","year":"2002","journal-title":"Annu. Rev. Psychol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ynstr.2014.11.002","article-title":"Resilience to the effects of social stress: Evidence from clinical and preclinical studies on the role of coping strategies","volume":"1","author":"Wood","year":"2015","journal-title":"Neurobiol. Stress"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Westhoff-Bleck, M., Lemke, L.H., Bleck, J.M.S., Bleck, A.C., Bauersachs, J., and Kahl, K.G. (2021). Depression Associated with Reduced Heart Rate Variability Predicts Outcome in Adult Congenital Heart Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081554"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/psyp.13031","article-title":"Loneliness and acute stress reactivity: A systematic review of psychophysiological studies","volume":"55","author":"Brown","year":"2017","journal-title":"Psychophysiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpsycho.2014.03.001","article-title":"Trait dominance is associated with vascular cardiovascular responses, and attenuated habituation, to social stress","volume":"92","author":"Lee","year":"2014","journal-title":"Int. J. Psychophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1469-8986.2010.01122.x","article-title":"Rumination in the laboratory: What happens when you go back to everyday life?","volume":"48","author":"Ottaviani","year":"2010","journal-title":"Psychophysiology"},{"key":"ref_12","first-page":"395","article-title":"Momentary changes in the cardiovascular autonomic system during mental loading in patients with panic disorder: A new physiological index","volume":"82","author":"Shioiri","year":"2004","journal-title":"J. Affect. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ziegler, M.G. (2004). Psychological Stress and the Autonomic Nervous System. Primer on the Autonomic Nervous System, Academic Press.","DOI":"10.1016\/B978-012589762-4\/50051-7"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fpsyg.2016.01091","article-title":"Subjective Social Status and Cardiovascular Reactivity: An Experimental Examination","volume":"7","author":"Pieritz","year":"2016","journal-title":"Front. Psychol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s12160-016-9858-9","article-title":"Life Satisfaction and Hemodynamic Reactivity to Mental Stress","volume":"51","author":"Schwerdtfeger","year":"2016","journal-title":"Ann. Behav. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.physbeh.2013.03.007","article-title":"Cardio-autonomic control and wellbeing due to oscillating color light exposure","volume":"114\u2013115","author":"Grote","year":"2013","journal-title":"Physiol. Behav."},{"key":"ref_17","unstructured":"Buckwalter, J., Rizzo, A., John, B., Finlay, L., Wong, A., Chin, E., and Seeman, T. (December, January 28). Analyzing the impact of stress: A comparison between a factor analytic and a composite measurement of allostatic load. Proceedings of the Interservice\/Industry Training, Simulation & Education Conference (I\/ITSEC), Orlando, FL, USA."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fphys.2012.00004","article-title":"A Unified Point Process Probabilistic Framework to Assess Heartbeat Dynamics and Autonomic Cardiovascular Control","volume":"3","author":"Chen","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1037\/a0032672","article-title":"Emotion regulation and emotion coherence: Evidence for strategy-specific effects","volume":"13","author":"Gross","year":"2013","journal-title":"Emotion"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gong, W., and Wang, S. (2009, January 19\u201321). Support Vector Machine for Assistant Clinical Diagnosis of Cardiac Disease. Proceedings of the 2009 WRI Global Congress on Intelligent Systems, Xiamen, China.","DOI":"10.1109\/GCIS.2009.186"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/jcbfm.2010.56","article-title":"Artificial Neural Network Prediction of Ischemic Tissue Fate in Acute Stroke Imaging","volume":"30","author":"Huang","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/TCRM.S16523","article-title":"A new Web-based medical tool for assessment and prevention of comprehensive cardiovascular risk","volume":"7","author":"Iervasi","year":"2011","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1037\/a0018350","article-title":"Mood, blood pressure, and heart rate at work: An experience-sampling study","volume":"15","author":"Ilies","year":"2010","journal-title":"J. Occup. Health Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1027\/0269-8803\/a000061","article-title":"Brain and Body","volume":"25","author":"Olbrich","year":"2011","journal-title":"J. Psychophysiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Salem, A.B.M., Revett, K., and El-Dahshan, E.S.A. (2009, January 12\u201314). Machine learning in electrocardiogram diagnosis. Proceedings of the 2009 International Multiconference on Computer Science and Information Technology, Mragowo, Poland.","DOI":"10.1109\/IMCSIT.2009.5352689"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neunet.2013.05.009","article-title":"Genuine cross-correlations: Which surrogate based measure reproduces analytical results best?","volume":"46","author":"Schindler","year":"2013","journal-title":"Neural Netw."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hussain, S., Raza, Z., Giacomini, G., and Goswami, N. (2021). Support Vector Machine-Based Classification of Vasovagal Syncope Using Head-Up Tilt Test. Biology, 10.","DOI":"10.3390\/biology10101029"},{"key":"ref_28","unstructured":"Seliger, A., and Hansen, L.B. (2013). Characterization and Discrimination of Pathological Electrocardiograms Using Advanced Machine Learning Methods, Technical University of Denmark."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10286-009-0001-x","article-title":"Heart rate and stroke volume response patterns to augmented orthostatic stress","volume":"19","author":"Goswami","year":"2009","journal-title":"Clin. Auton. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biopsycho.2009.11.008","article-title":"Trait and state positive affect and cardiovascular recovery from experimental academic stress","volume":"83","author":"Papousek","year":"2010","journal-title":"Biol. Psychol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/PSY.0b013e3181810658","article-title":"Covariance Between Psychological and Endocrine Responses to Pharmacological Challenge and Psychosocial Stress: A Question of Timing","volume":"70","author":"Schlotz","year":"2008","journal-title":"Psychosom. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ajhb.22815","article-title":"Beyond catecholamines: Measuring autonomic responses to psychosocial context","volume":"28","author":"Decaro","year":"2015","journal-title":"Am. J. Hum. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopsycho.2005.10.010","article-title":"Domestic violence and vagal reactivity to peer provocation","volume":"74","author":"Katz","year":"2007","journal-title":"Biol. Psychol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kemp, A.H., Arias, J.A., and Fisher, Z. (2017). Social Ties, Health and Wellbeing: A Literature Review and Model. Neuroscience and Social Science, Springer.","DOI":"10.1007\/978-3-319-68421-5_17"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/icd.688","article-title":"The early development of the autonomic nervous system provides a neural platform for social behaviour: A polyvagal perspective","volume":"20","author":"Porges","year":"2010","journal-title":"Infant Child Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/spc3.12052","article-title":"The Biopsychosocial Model of Challenge and Threat: Using the Heart to Measure the Mind","volume":"7","author":"Seery","year":"2013","journal-title":"Soc. Personal. Psychol. Compass"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1037\/1528-3542.6.3.484","article-title":"Cultural and temperamental variation in emotional response","volume":"6","author":"Tsai","year":"2006","journal-title":"Emotion"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/dev.20013","article-title":"Longitudinal relations between child vagal tone and parenting behavior: 2 to 4 years","volume":"45","author":"Kennedy","year":"2004","journal-title":"Dev. Psychobiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1467-9280.1992.tb00251.x","article-title":"Autonomic Nervous System Differences among Emotions","volume":"3","author":"Levenson","year":"1992","journal-title":"Psychol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/psyp.12159","article-title":"The temporal dynamics of cognitive reappraisal: Cardiovascular consequences of downregulation of negative emotion and upregulation of positive emotion","volume":"51","author":"Pavlov","year":"2013","journal-title":"Psychophysiology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0191-8869(91)90030-F","article-title":"Personality, temperament and the cardiac defense response","volume":"12","author":"Richards","year":"1991","journal-title":"Personal. Individ. Differ."},{"key":"ref_42","first-page":"1014","article-title":"Capacity theory: A neuropsychological perspective on shared neural systems regulating hostile violence prone behavior and the metabolic syndrome","volume":"3","author":"Walters","year":"2016","journal-title":"J. Neurol. Disord. Epilepsy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1469-8986.1994.tb01032.x","article-title":"Social neuroscience: Autonomic, neuroendocrine, and immune responses to stress","volume":"31","author":"Cacioppo","year":"1994","journal-title":"Psychophysiology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biopsycho.2004.03.009","article-title":"Feelings and emotions: Roles for electrophysiological markers","volume":"67","author":"Cacioppo","year":"2004","journal-title":"Biol. Psychol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0005-7967(70)90069-0","article-title":"The psychophysiological basis of introversion-extraversion","volume":"8","author":"Gray","year":"1970","journal-title":"Behav. Res. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Gray, J.A. (1981). A Critique of Eysenck\u2019s Theory of Personality. A Model for Personality, Springer.","DOI":"10.1007\/978-3-642-67783-0_8"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1469-8986.1980.tb00117.x","article-title":"The Three Arousal Model: Implications of Grays Two-Factor Learning Theory for Heart Rate, Electrodermal Activity, and Psychopathy","volume":"17","author":"Fowles","year":"1980","journal-title":"Psychophysiology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1086\/228745","article-title":"How Many Emotions Are There? Wedding the Social and the Autonomic Components","volume":"93","author":"Kemper","year":"1987","journal-title":"Am. J. Sociol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1162\/0898929042947847","article-title":"The Interaction of Social and Emotional Processes in the Brain","volume":"16","author":"Norris","year":"2004","journal-title":"J. Cogn. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-0447.1988.tb09007.x","article-title":"A theoretical framework for linking the experience of dysfunctional parental rearing attitudes with manifest psychopathology","volume":"78","author":"Perris","year":"1988","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_51","unstructured":"Coles, G.H., Donchin, E., and Porges, S.W. (1986). Emotion and psychophysiological organization: A systems approach. Psychophysiology: Systems, Processes, and Applications, Elsevier."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jpr.12089","article-title":"Hemodynamic responses to active and passive coping tasks and the prediction of future blood pressure in Thai participants: A preliminary prospective cohort study","volume":"57","author":"Yuenyongchaiwat","year":"2015","journal-title":"Jpn. Psychol. Res."},{"key":"ref_53","first-page":"211","article-title":"Psychosocial correlates of peripheral vegetative activity and coordination","volume":"35\u201336","author":"Gandarillas","year":"2011","journal-title":"Aletheia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1556\/APhysiol.96.2009.2.2","article-title":"Individual stability of orthostatic tolerance response","volume":"96","author":"Goswami","year":"2009","journal-title":"Acta Physiol. Hung."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biopsycho.2005.08.008","article-title":"Polyvagal Theory and developmental psychopathology: Emotion dysregulation and conduct problems from preschool to adolescence","volume":"74","author":"Beauchaine","year":"2007","journal-title":"Biol. Psychol."},{"key":"ref_56","unstructured":"Hall, J.E., and Guyton, A.C. (2016). Guyton and Hall Textbook of Medical Physiology, Elsevier."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1113\/expphysiol.2005.032250","article-title":"Arterial baroreflex resetting during exercise: A current perspective","volume":"91","author":"Raven","year":"2006","journal-title":"Exp. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3928\/00485713-20091124-03","article-title":"Brain-Body Interactions: The Physiological Impact of Mental Processes\u2014The Neurobiology of the Stress Response","volume":"39","author":"Viamontes","year":"2009","journal-title":"Psychiatr. Ann."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/cr015001","article-title":"Hidden Markov model for downscaling synoptic atmospheric patterns to precipitation amounts","volume":"15","author":"Bellone","year":"2000","journal-title":"Clim. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3354\/cr008195","article-title":"Downscaling climate model outputs into local and regional weather elements by classification and regression","volume":"8","author":"Enke","year":"1997","journal-title":"Clim. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S1352-2310(97)00447-0","article-title":"Artificial neural networks (the multilayer perceptron)\u2014A review of applications in the atmospheric sciences","volume":"32","author":"Gardner","year":"1998","journal-title":"Atmos. Environ."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5194\/npg-18-295-2011","article-title":"Extreme events: Dynamics, statistics and prediction","volume":"18","author":"Ghil","year":"2011","journal-title":"Nonlinear Processes Geophys."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"813","DOI":"10.5194\/acp-9-813-2009","article-title":"On the diagnosis of climate sensitivity using observations of fluctuations","volume":"9","year":"2009","journal-title":"Atmos. Chem. Phys."},{"key":"ref_64","unstructured":"Miller, N.L., Duffy, P.B., Cayan, D.R., Hidalgo, H., Jin, J., Kanamaru, H., O\u2019Brien, T., Schlegel, N.J., Sloan, L.C., and Snyder, M.A. (2022, May 03). An Analysis of Simulated California Climate Using Multiple Dynamical and Statistical Techniques. Available online: https:\/\/escholarship.org\/uc\/item\/9hh481gh."},{"key":"ref_65","unstructured":"Cofino, A.S., Cano, R., Sordo, C., and Gutierrez, J.M. (2002, January 21\u201326). Bayesian networks for probabilistic weather prediction. Proceedings of the European Conference on Artificial Intelligence (ECAI), Lyon, France."},{"key":"ref_66","first-page":"387","article-title":"Cancer patient-centered home care: A new model for health care in oncology","volume":"7","author":"Tralongo","year":"2011","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_67","first-page":"485","article-title":"Detection and remediation of medically urgent situations using telemedicine case management for older patients with diabetes mellitus","volume":"3","author":"Izquierdo","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.2147\/TCRM.S87751","article-title":"Study of ambulatory blood pressure in diabetic children: Prediction of early renal insult","volume":"11","author":"Shalaby","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2147\/CIA.S177286","article-title":"Merging current health care trends: Innovative perspective in aging care","volume":"13","author":"Gandarillas","year":"2018","journal-title":"Clin. Interv. Aging"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3869\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:42:26Z","timestamp":1760139746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":69,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["jcm11133869"],"URL":"https:\/\/doi.org\/10.3390\/jcm11133869","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,4]]}}}