{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:38:09Z","timestamp":1762058289471,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Electrical storm (ES) is defined by clustering episodes of ventricular tachycardia (VT) and is associated with severe long-term outcomes. We sought to evaluate the prognostic impact of radiofrequency catheter ablation (RFCA) in ES as assessed by aggressive programmed ventricular stimulation (PVS). Methods: Single-center retrospective longitudinal study with 82 consecutive ES patients referred for RFCA with a median follow-up (IQR 25\u201375%) of 45.43 months (15\u201369.86). All-cause mortality and VT recurrences were assessed in relation to RFCA outcomes defined by 4-extrastimuli PVS: Class 1\u2014no ventricular arrhythmia; Class 2\u2014no sustained monomorphic VTs (mVT) inducible, but non-sustained mVTs, polymorphic VTs, or VF inducible; Class 3\u2014clinical VT non-inducible, other sustained mVTs inducible; and Class 4\u2014clinical VT inducible. Results: Class 1, Class 2, Class 3, and Class 4 were achieved in 56.1%, 13.4%, 23.2%, and 7.4% of cases, respectively. The combined outcome of Class 1 + Class 2 (no sustained monomorphic VT inducible) led to improved survival (log-rank p &lt; 0.001) and reduced VT recurrence (log-rank p &lt; 0.001). Residual monomorphic VT inducibility (HR 6.262 (95% CI: 2.165\u201318.108, p = 0.001), NYHA IV heart failure symptoms (HR 20.519 (95% CI: 1.623\u2013259.345), p = 0.02)), and age (HR 1.009 (95% CI: 1.041\u20131.160), p = 0.001)) independently predicted death during follow-up. LVEF was not predictive of death (HR 1.003 (95% CI: 0.946\u20131.063) or recurrences (HR 0.988 (95% CI: 0.955\u20131.021)). Conclusions: Non-inducibility for sustained mVTs after aggressive PVS post-RFCA leads to improved survival in ES, independently of LVEF.<\/jats:p>","DOI":"10.3390\/jcm11133887","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T11:15:05Z","timestamp":1656933305000},"page":"3887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monomorphic VT Non-Inducibility after Electrical Storm Ablation Reduces Mortality and Recurrences"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-8528","authenticated-orcid":false,"given":"Radu","family":"V\u0103t\u0103\u0219escu","sequence":"first","affiliation":[{"name":"Cardiology Department, Emergency Clinical Hospital of Bucharest, 014461 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-3939","authenticated-orcid":false,"given":"Cosmin","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"Cardiology Department, Emergency Clinical Hospital of Bucharest, 014461 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandrina","family":"N\u0103stas\u0103","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cElias\u201d University Emergency Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Popescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corneliu","family":"Iorgulescu","sequence":"additional","affiliation":[{"name":"Cardiology Department, Emergency Clinical Hospital of Bucharest, 014461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0218tefan","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Emergency Clinical Hospital of Bucharest, 014461 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Gondo\u0219","sequence":"additional","affiliation":[{"name":"Department of Medical Electronics and Informatics, Polytechnic University of Bucharest, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Berruezo","sequence":"additional","affiliation":[{"name":"Teknon Medical Center, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1161\/01.CIR.103.16.2066","article-title":"Electrical storm presages nonsudden death: The antiarrhythmics versus implantable defibrillators (AVID) trial","volume":"103","author":"Exner","year":"2001","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.hrthm.2007.07.013","article-title":"Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: A MADIT-II substudy","volume":"4","author":"Sesselberg","year":"2007","journal-title":"Heart Rhythm"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.hrthm.2017.08.022","article-title":"Successful ventricular tachycardia ablation in patients with electrical storm reduces recurrences and improves survival","volume":"15","author":"Vergara","year":"2017","journal-title":"Heart Rhythm"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jacep.2017.01.020","article-title":"Long-Term Outcomes of Catheter Ablation of Electrical Storm in Nonischemic Dilated Cardiomyopathy Compared with Ischemic Cardiomyopathy","volume":"3","author":"Muser","year":"2017","journal-title":"JACC Clin. 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