{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:08:57Z","timestamp":1777158537683,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung foundation","doi-asserted-by":"publisher","award":["20160787"],"award-info":[{"award-number":["20160787"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung foundation","doi-asserted-by":"publisher","award":["20200160"],"award-info":[{"award-number":["20200160"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung foundation","doi-asserted-by":"publisher","award":["2019\u201301338"],"award-info":[{"award-number":["2019\u201301338"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Research Council","award":["20160787"],"award-info":[{"award-number":["20160787"]}]},{"name":"Swedish Research Council","award":["20200160"],"award-info":[{"award-number":["20200160"]}]},{"name":"Swedish Research Council","award":["2019\u201301338"],"award-info":[{"award-number":["2019\u201301338"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cardiac amyloidosis is an underdiagnosed condition and simple methods for accurate diagnosis are warranted. We aimed to validate a novel, dual-modality approach to identify transthyretin cardiac amyloidosis (ATTR-CA), employing echocardiographic relative wall thickness (RWT), and ECG S-wave from aVR (SaVR), and compare its accuracy with conventional echocardiographic approaches. Material and methods: We investigated 102 patients with ATTR-CA and 65 patients with left ventricular hypertrophy (LVH), all with septal thickness &gt; 14 mm. We validated the accuracy of echocardiographic measures, including RWT, RWT\/SaVR, posterior wall thickness (PWT), LV mass index (LVMI), left atrial volume index (LAVI), global longitudinal strain (GLS), and relative apical sparing (RELAPS) to identify ATTR-CA diagnosed using DPD-scintigraphy or abdominal fat biopsy. Results: PWT, RWT, RELAPS, troponin, and RWT\/SaVR were significantly higher in ATTR-CA compared to LVH. RWT\/SaVR &gt; 0.7 was the most accurate parameter to identify ATTR-CA (sensitivity 97%, specificity 90% and accuracy 91%). RELAPS was found to have much less accuracy (sensitivity 74%, specificity 76% and accuracy 73%). Conclusion: We can confirm the very strong diagnostic accuracy of RWT\/SaVR to identify ATTR-CA in patients with septal thickness &gt; 14 mm. Given its high sensitivity and specificity, RWT\/SaVR &gt; 0.7 has the potential to implement as a non-invasive, simple, and widely available diagnostic tool when screening for ATTR-CA.<\/jats:p>","DOI":"10.3390\/jcm11144120","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T22:57:06Z","timestamp":1658098626000},"page":"4120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["RWT\/SaVR\u2014A Simple and Highly Accurate Measure Screening for Transthyretin Cardiac Amyloidosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Elsa","family":"Arnberg","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Surgical & Perioperative Sciences, Umea University, SE-901 85 Umea, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Eldhagen","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"L\u00f6fbacka","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Surgical & Perioperative Sciences, Umea University, SE-901 85 Umea, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-0604","authenticated-orcid":false,"given":"Ashwin","family":"Venkateshvaran","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Pilebro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Public Health and Clinical Medicine, Umea University, SE-901 85 Umea, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-9166","authenticated-orcid":false,"given":"Per","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Surgical & Perioperative Sciences, Umea University, SE-901 85 Umea, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3109\/13506129.2013.797890","article-title":"Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis","volume":"20","author":"Ihse","year":"2013","journal-title":"Amyloid"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jchf.2021.07.005","article-title":"Recognition and Implications of Undiagnosed Cardiac Amyloid Patients in HFpEF Trials","volume":"9","author":"Cheng","year":"2021","journal-title":"JACC Heart Fail."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jchf.2020.12.005","article-title":"The Impact of Patients With Cardiac Amyloidosis in HFpEF Trials","volume":"9","author":"Oghina","year":"2021","journal-title":"JACC Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: A position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"42","author":"Rapezzi","year":"2021","journal-title":"Eur. 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