{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:11:15Z","timestamp":1760238675921,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Heart and Lung Association","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"name":"Medical Faculty of Lund University","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"name":"ALF funds","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"name":"Sk\u00e5ne University Hospital Funds","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"publisher","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}],"id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ernhold Lundstr\u00f6ms Research Foundation","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"name":"Hulda and Conrad Mossfelt Foundation","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]},{"name":"Anna-Lisa and Sven Eric Lundgrens Foundation for Medical Research","award":["20190383","DNR FA 2018:29","20190756"],"award-info":[{"award-number":["20190383","DNR FA 2018:29","20190756"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of &lt;30, 30\u201360, and &gt;60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (&lt;30 years: 66.9 \u00b1 6.2, 30\u201360: 64.5 \u00b1 6.1, &gt;60: 62.2 \u00b1 5.8%; p = 0.009) and orthostatic hypotension (&lt;30: 67.4 \u00b1 4.4, 30\u201360: 61.6 \u00b1 6.2, &gt;60: 57.5 \u00b1 3.9; p &lt; 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals.<\/jats:p>","DOI":"10.3390\/jcm11154302","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T21:20:59Z","timestamp":1658784059000},"page":"4302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9150-1289","authenticated-orcid":false,"given":"Isabella","family":"Kharraziha","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Torabi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"},{"name":"Department of Clinical Physiology, Sk\u00e5ne University Hospital, 214 28 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-9148","authenticated-orcid":false,"given":"Madeleine","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, 214 28 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-1094","authenticated-orcid":false,"given":"Richard","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"},{"name":"National Heart and Lung Institute, Imperial College, Hammersmith Hospital Campus, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Karolinska University Hospital, 171 64 Solna-Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-0866","authenticated-orcid":false,"given":"Viktor","family":"Hamrefors","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 202 13 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, 214 28 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1016\/0002-9149(86)91025-8","article-title":"Alterations in cardiovascular structure and function with advancing age","volume":"57","author":"Fleg","year":"1986","journal-title":"Am. 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