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This study aims to better understand the potential factors that contribute to this phenomenon, especially among cancer patients who are considered as a high-risk group for developing severe COVID-19. Methods: Plasma samples collected during the COVID-19 pandemic from SARS-CoV-2 unvaccinated cancer and potential blood donor populations were analyzed for SARS-CoV-2 (spike and nucleocapsid proteins) antibodies by an immunofluorescence assay. The relationships between SARS-CoV-2 seroprevalences and study variables were determined using a logistic regression analysis. Results: High seroprevalence against the SARS-CoV-2 spike and nucleocapsid proteins were found among the SARS-CoV-2 unvaccinated COVID-19 pandemic populations in SSA. However, the cancer patients demonstrated a lower seroprevalence compared to potential blood donors. There was also an association between mild COVID-19 symptoms with prior tuberculosis vaccination among cancer patients. Conclusion: Cancer patients in SSA tend to have a relatively lower SARS-CoV-2 seroprevalence compared to potential blood donors recruited from the same geographic locations during the COVID-19 pandemic. More study is required to determine its cause and potential impact on SARS-CoV-2 vaccination among cancer patients.<\/jats:p>","DOI":"10.3390\/jcm11154428","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T02:06:42Z","timestamp":1659319602000},"page":"4428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lower SARS-CoV-2 Seroprevalence among Cancer Patients in Sub-Saharan Africa"],"prefix":"10.3390","volume":"11","author":[{"given":"For Yue","family":"Tso","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Oncology, and the Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-6595","authenticated-orcid":false,"given":"Salum J.","family":"Lidenge","sequence":"additional","affiliation":[{"name":"Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"},{"name":"Department of Clinical Oncology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Ngowi","sequence":"additional","affiliation":[{"name":"Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-5108","authenticated-orcid":false,"given":"Phoebe B.","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Nebraska Center for Virology, Lincoln, NE 68583, USA"},{"name":"School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-1639","authenticated-orcid":false,"given":"Ashley A.","family":"Clegg","sequence":"additional","affiliation":[{"name":"Nebraska Center for Virology, Lincoln, NE 68583, USA"},{"name":"School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-4128","authenticated-orcid":false,"given":"Owen","family":"Ngalamika","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Section, University Teaching Hospitals, University of Zambia School of Medicine, Lusaka P.O. Box 50110, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chacha J.","family":"Mwita","sequence":"additional","affiliation":[{"name":"Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Mwaiselage","sequence":"additional","affiliation":[{"name":"Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"},{"name":"Department of Clinical Oncology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, and the Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. 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